The present study was aimed to look for the effect of a natural compound i.e. Crocin on the viability of mature adipocytes and on inhibition of adipocyte differentiation. The 3T3-L1 cell line is one of the most well-characterized and reliable models for studying the conversion of pre-adipocytes into adipocytes. 3T3- L1 pre-adipocytic cell line was used and differentiated into mature adipocytes using standard adipogenic media. The MTT assay was used for the assessment of cell viability whereas effect on adipocyte differentiation was visualised by Oil Red O staining. The changes in relative lipid content were monitored spectrophotometrically at 510nm. Mature adipocytes when treated with Crocin decreased cell viability in a dose dependent manner. It also showed an enhanced inhibition of adipocyte differentiation as monitored by Oil Red O Staining. The western blot analysis revealed significant increase in the expression levels of AMP activated protein Kinase which is a key regulator of energy homeostasis. Thus, the crocin seems to affect multi-potent anti-obesity parameters and may have promising benefits for the treatment and prevention of obesity.

One of the common clinical observations regarding long-standing diabetes is peripheral neuropathic pain, probably due to its destructive effects on the pain modulating neurons of the dorsal gray column of the spinal cord. Accordingly, the current study was aimed to analyze the effect of experimental hyperglycemia on pain modulating neurons in the lamina I-III of lumbar region of spinal cord of albino rats. Thirty-six albino rats with average weight ~250 g were grouped equally into six. Diabetes was induced with a single dose of streptozotocin (STZ, 60 mg/kg, i.p.). At the end of each experimental period, rats were euthanized by deep ether anesthesia, blood was collected and animals were perfused with Karnovsky fixative. Spinal cord was dissected and processed for histopathological and morphometric parameters and blood for biochemical analysis. Biochemical analysis of all diabetic groups revealed increased serum creatinine and reduced serum total protein. Histopathology and histomorphometry of dorsal gray column and ependymal cells and surrounding structures revealed that with the progressively increasing duration of hyperglycemia was associated with decreased number of pain modulating neurons in the lamina I-III as well as ependymal cell and in addition deposition of collagen fibers in the tunica adventitia of spinal arteries and around the small spinal vessels. The associations of long-standing hyperglycemia with reduction of dorsal gray column inter neurons, demyelination of nerve fibres and excessive deposition of collagen fibers in the tunica adventitia of blood vessels appear to be important contributing factors likely to be responsible for the diabetes-induced peripheral neuropathic pain

Abstract: Since the dawn of the era of innovation, the need for novel methods in making life easier has been interminable. The learning process shows no exceptions to this rule. One would argue for the classic methods in handling the trade of information between the teacher and the students, which has been unilateral. The introduction of problem based learning (PBL) process to the system of education is facing many struggles. In this student-centered active learning process, the teacher is just a guide focal point of education systems. Literature search strategy included electronic database searches, internet searches, hand searching, ancestry searching and networking. Objectives: The objective of this review article is to study the challenges, obstacles and critical incident in PBL tutorial groups. Problem base learning model is counteracting by a lot of educational, financial and psychological challenges and barriers.

Ultrasonography is the most common screening test for cholecystitis and cholelithiasis. It is easy, non invasive, and safe and a highly accurate imaging technique that can also detect associated lesions of the liver, pancreas and common bile duct (CBD). Recent studies have demonstrated that laparoscopic removal of gallbladder may be accomplished with a morbidity and mortality rate comparable to or less than that of traditional open cholecystectomy. The present study was conducted to look for some predictive factors on ultrasonography of gallbladder that can give surgeon some idea about the potential difficulty and complications that may be encountered during the course of laparoscopic cholecystectomy. This study presents analysis of 51 patients of cholelithiasis, requiring elective cholecystectomy from 1st May 2008 to 30th April 2009. The study was conducted in the Department of Surgery and Department of Radio diagnosis, G.R. Medical College, Gwalior (M.P.). The ultrasonography of the patients was done on the day of surgery in the department of Radio diagnosis, G.R. Medical College, Gwalior. The patients were fasting overnight for the maximal distention of the gallbladder. The ultrasonography was done with 3.5 Mhz probe on Diatonic spectra color Doppler ultrasound on B mode, gray scale, real time scan.The mean gallbladder wall thickness in the study was 2.9 mm (maximum - 5.6 mm and minimum – 1.8 mm). There were 8 patients who had gallbladder wall thickness more than 4 mm. There were 7 (13.2%) patients with contracted gallbladder. There were 6 (11.76 %) patients with gallstone impacted at the neck of gallbladder or Hartman's pouch. There were only 2 patients with common bile duct diameter more than 6 mm. Out of total 51 cases 7 (13.72%) cases were converted to open procedure. Significant correlation was found between the independent ultra-sonographic parameters (that is gallbladder wall thickness, contracted gallbladder, stone impaction at the neck of gallbladder) with the difficult laparoscopic cholecystectomy and their subsequent conversion to open cholecystectomy. The most valuable assessment the ultrasound can provide is the gall bladder wall thickness, gall bladder size, CBD diameter and CBD stones and any abnormal anatomy of the biliary tract if present. Thick gallbladder wall is a finding, which may show that more adhesions may be found during surgery.

Marine macroalgae produce a great variety of biological active compounds which cannot be scientifically characterized with in other organism’s biomass. These marine habitats have been scientifically reported for modern medicinal uses although rheteoratically associated to coastal communities’ healthy eating and folk medicine practice. In tandem to this, these marine macroalgae have highly potentiate themselves as a tangible source of functional ingredients that is industrial applicable. Globally various division of geochemical marine macroalgae flora taxa (Chlorophyta, Phaeophyta, and Rhodophyta) flourish. However, despite substantial optimised yield and empirical evidence of their health potential benefits, these macroalgae remained largely pharmaceutical and medical related industries innovative unexploited. Of these leads compounds, sulfated polysaccharides offer a wide range of physiological and chemical-biological activities that include antioxidative, anticoagulant, antiviral, antitumor, anti-inflammatory, antihyperlipidemic and antihepatotoxic activities. Per se, the optimization of sulfated polysaccharides as functional food and Vis a Vis, as therapeutic agents is this millennium important research agenda. As such, this review extrapolates the bioprospect of sulfated polysaccharides (Sulfated galactans, Fucans, and Ulvans) from geochemical signature macroalgae potential context as functional food and as tangible source for drug discovery.

The Swedish financial crisis, dealing with financial deregulation and the boom in the late 1980s, the bust and the financial crisis in the early 1990s, the recovery from the crisis and the bank resolution policy adopted during the crisis are reviewed. The paper focuses on: the causes and consequences of the financial crisis, and the applicability of the Swedish model of bank crisis management for countries currently facing financial problems.

Obesity, a pathologic state characterised by excess fat reserves, is a serious health problem that increases the risk of numerous medical complications and mortality. The disease arises as a direct consequence of alterations in regulating energy balance in the body. The recent global rise in the prevalence of Obesity and unavailability of effective anti-obesity drugs has created an urgent need to understand and identify the important aspects related to the disease. In this review, we provide a perspective on the factors influencing Obesity, Obesity-associated disorders, pharmacological interventions and several other important concepts related to the disease.

Eventhough Tuberculosis is widespread in India; parotid gland involvement is very rare. TB primarily affects the lung, but in about 15 – 20% of the cases extra pulmonary involvement can be seen. Here we present a case of TB parotid abscess in a 45 year old diabetic male patient

Weed infestation is one of the major threats to crop growth and yield.Weed control is the method of limiting weed infestation so that crops can be grown profitably. Metsulfuron methyl + Chlorimuron ethyl is a new post-emergence herbicide in Bangladesh. Field trials were conducted at Bangladesh Rice Research Institute (BRRI), Gazipur during Aman, 2014 and Boro, 2014-15 to evaluate the efficacy of Metsulfuron methyl 10% + Chlorimuron ethyl 2% WP on weed suppression and performance of transplanted rice. Metsulfuron methyl 10% + Chlorimuron ethyl 2% WP @ 15, 20 and 25 g ha-1 were applied and Pyrazosulfuran ethyl @ 125 g ha-1, weed free and unweeded control were used for comparison. Visual observation indicated that this herbicide possesses high selectivity and not toxic to rice plants. The results revealed that the major weed flora associated with the transplanted rice was mainly comprised of two grasses, two sedges and three broadleaves in Aman, 2014 and two grasses, two sedge and two broad leaves in Boro, 2014-15. The most dominant weeds were Cyperus difformis, Echinochloa crus-galli, Scirpus maritimus and Monochoria vaginalis in both the growing seasons. Application of Metsulfuron methyl 10% + Chlorimuron ethyl 2% WP @ 20 g ha-1 was most effective to suppress weed density and dry masses in both the seasons resulting increased grain yield more than 30% as compared to unweeded control. Therefore, Metsulfuron methyl 10% + Chlorimuron ethyl 2% WP @ 20 g ha-1 should apply at one to two leaf stage of weed may be recommended for effectively control weed in transplanted rice.

Cinnamon has a long history both as a spice and as a medicine. This study was carried out to screen the phytochemicals of the extract as well as to evaluate the acute (LD50) and sub-chronic toxicities of aqueous bark extract of Cinnamomum verum in rats. A total of twenty eight rats were used in this study, thirteen for acute toxicity test and fifteen for sub chronic toxicity. The acute toxicity study was done in two phases; in phase I, nine rats were divided into three groups of three rats each and were administered the aqueous bark extract of Cinnamomum verum at different doses of 10, 100 and 1000mg/kg body weight orally. The rats were observed for mortality and general behavior for 24hrs. In phase II, four rats were administered with aqueous bark extract of Cinnamomum verum at higher doses of 1500, 2500, 3500 and 5000mg/kg and were observed for mortality and other signs of toxicity for 24hrs. For the sub chronic toxicity experiment, fifteen rats were divided into five groups of three rats each. Group 1 was the control group, groups II to V were orally administered 50, 100, 150 and 200mg/kg of aqueous bark extract of Cinnamomum verum respectively for four weeks. The rats were sacrificed and blood samples collected for biochemical analysis of liver and kidney functions. The result of phytochemical screening revealed the presence of saponins, reducing sugars, flavonoids, steroids, resins and cardiac glycosides. Acute toxicity revealed that the extract was practically non-toxic with oral LD50 greater than 5000mg/kg body weight. The levels of ALP, ALT, AST and TP of the test groups decreased significantly (p<0.05) with respect to control group while serum TB, ALB increased with respect to control group. A significant decrease (p<0.05) in serum electrolytes, creatinine and urea and an increase in serum bicarbonate was observed in extract administered groups in a dose dependent pattern compared to normal control. In conclusion, these results showed that the extract is rich in phytochemicals and was found to be relatively safe at administered doses

Abstract: In this study, it was aimed to determine the adaptations, yield potentials of some dry bean genotypes and some agricultural characteristics to the Central Anatolian ecology. The research was carried out in three replications according to the randomized blocks design for two years in 2015 and 2016 in a farmer’s experiment area in the center of Mucur district of Kirsehir province. It was determined that there were significant statistical differences between the genotypes in terms of all examined yield parameters. When the agronomic characteristics of the genotypes were evaluated together, it was found that K.1084, A.40, A.130 and GK.314 genotypes had very low values of yield parameters and Goynuk 98, Sahin 90 and A.27 genotypes were found to be more suitable for adaptation to Kirsehir ecological conditions than other genotypes. It was suggested that these genotypes should be laid emphasis on in terms of region.

This study examines the macroeconomic factors which are affecting to real effective exchange rates (REER) from selected ten countries in Asia. Two panel regression approaches namely fully modified ordinary least squares (FMOLS), dynamic ordinary least squares (DOLS) and fixed effects are applied using panel data over the period 2002–2016. Empirical results show that presence of a significant long-term association amongst the REER and seven macroeconomic determents namely interest rate, inflation, trade balance, terms of trade, trade openness, foreign reserves and share price index and their significance are remaining same in all models applied. However, trade balance has a positive connection with the REER while other significant variables have a negative association with the REER in long run. Moreover, the money supply (M2) and real gross domestic production (GDP) do not show a significant relationship with the REER.

The purpose of this study is to identify and find community participation in education which is part of effective school management implementation through leadership of principal in making effective school in Jambi Province. Effective school management describes schools that have good, transparent and accountable management that are able to empower all school components to effectively achieve school goals. The research methodology used is descriptive qualitative approach. The data collection techniques using observation, interview and documentation. For validity technique of data using triangulation in three research locations, Senior High School 1 Jambi City, Senior High School 1 Bungo and Senior High School 1 Merangin The results research of the study are: (1) effective school management at three high schools in Jambi Province (Senior High School 1 Kota Jambi, Senior High School 1 Bungo and Senior High School 1 Merangin) has been implemented through management function, (2) of the three schools, its found that the community participation to support of effective school at Senior High School 1 Jambi city is relatively low, (3) community participation at the three schools is evident, in which they successfully achieve the educational objectives and targets that have been established with the involvement of school committees and stakeholders. The conclusion of this study is that the minimum level of community participation at schools seems to be the result of unclear procedures of school committee recruitment. In most cases, the members of school committees are on the basis of familiarity and popularity. In addition, poor communication between school committees and school as well as unclear roles and responsibility contribute to the low level of community participation in education.

Aim of the present work was to prepare the colon-targeting pH dependent microcapsules of Thymoquinone for the treatment of colorectal cancer. pH dependent polymer Eudragit L100,and S100 were used to formulate the microcapsules by solvent evaporation technique using two methods. Microcapsules were evaluated for particle size, shape, flow properties, surface morphology by scanning electron microscopy, percentage yield, drug content, and in vitro drug release behaviour, in vivo targeting efficiency. The formulated microcapsules were discrete, almost spherical with somewhat folded and invaginated surface, and with good flow properties. Thymoquinone loaded microcapsules demonstrated good entrapment efficiency (of 86.438% in method 1 and 92.49% in method 2). Result of in vivo targeting efficiency showed that the formulation can able to target colon effectively. Formulation done by method 2 gave most promising result compared to first method. It is concluded from the present study that pH dependent Eudragit microcapsules are promising carriers for oral colon-targeted delivery of Thymoquinone for colorectal cancer.

Potentially malignant disorders and oral cancer are common diseases effecting oral cavity. The survival rate of these patients has not much improved, inspite of advances in the treatment modalities, due to their adverse effects. Many alternative medicines such as turmeric, aloevera, neem, tulsi, green tea, photo dynamic therapy, CO2 laser and stem cell culture etc are used to overcome these adverse effects. The aim of this study is to investigate the efficacy of turmeric along with honey in reducing the burning sensation in oral submucous fibrosis. Clinically diagnosed 30 patients of Oral Submucous Fibrosis (OSMF) were selected and local application of turmeric and honey was advised. Burning sensation using VAS scale was evaluated after 30 days. Statistical analysis was done using‘t’ test. There was significant decrease in VAS scale after treatment. In our study turmeric and honey showed positive results in reducing burning sensation in OSMF.