Prostate cancer is the second most common cancer and sixth leading cause of cancer death among men worldwide, with an estimated recorded number of 1.1 million cases and 307,000 deaths which allocates 15% of all new cases of cancer in men. Androgen receptor (AR) expression is maintained throughout prostate cancer progression, and the majority of androgen –independent or hormone refractory prostate cancers express Androgen receptor. HER2/neu, a biological marker named human epidermal growth factor receptor -2[EGFR-2] is also known as c-erb-2 plays a major role in understanding the oncogenesis of prostate adenocarcinoma and has a significant prognosis in the disease. Aim of The Study: To study the histomorphological features and grading of prostatic neoplasms with Gleason’s scoring. To study over the expression of HER2/neu & androgen receptor status in prostate neoplasm. To study the correlation of Gleason’s scoring with AR & HER2/neu expression in prostate cancer. All patients who were diagnosed to have prostatic cancer and PIN and were diagnosed by prostatic biopsy either by prostatectomy, TURP or Trucut procedure were included in the study and were examined for analyzing various histomorphological features and grading of various neoplasms of prostate with correlation to overexpression of immmunohistochemical markers Her2/neu and AR. Conclusion: This study may help the clinician in finding out her2/neu over expressed cases and implementing anti her2/neu therapy along with androgen deprived therapy for longer survival of prostate cancer patients although further studies on larger series of prostate carcinoma is required for new generation of more efficient anti her2 drugs.

Background: The Covid-19 pandemic has required the world’s educational sector to rapidly adjust its delivered methods and not to be too dependent on face-to-face interactions. The Ministry of Education in Saudi Arabia took advantage of what was already a well-developed common digital platform to extend its use of multimedia remote working. Aim and methods: This integrative review aims to address the effectiveness of multimedia distance education on university students and in particular nurses’ knowledge and skill development. Result: Eighteen articles were included and organized into two themes: what Types of multimedia methods are there in use for skills development and effectiveness of multimedia methods at augmenting practical skills in the Kingdom of Saudi Arabia. Summary: The challenge in the post-pandemic era for Saudi health care education is to conduct a fresh examination of how and what types of e-learning or m-learning can supplement or augment nurses knowledge and practical skills development. However, the principal lesson to be learnt from this review is that the technological development and design of any of the systems has to meaningfully address the learners' needs and not just simply drive learning per se. Key messages: Saudi Arabia’s Universities are well situated to take full advantage of the expansion of e-learning initiatives. Nursing Departments need to explore the use of augmented reality to improve the development of practical knowledge and skill, but what is developed must be driven by the learner’s individual ability and needs.

Tuberculosis (TB) is a communicable disease that is a major cause of ill health, one of the top 10 causes of death worldwide. Actually, TB is curable disease if the patients adhere and treatment be effective. This study aims to identify factors related to medication adherence among pulmonary TB patients. This study was a systematic literature review by identifying cross-sectional study, published in 2016-2021, in English and Indonesian, and full-text. The electronic database that used was Google Scholar and Science Direct with the keywords “Factors” “Medication” AND “Adherence” “TB Pulmonary”. The results obtained 10 articles that related to medication adherence among pulmonary TB patients. There were five dimensions of factors: therapeutic factors, health system factors, environmental factors, socioeconomic factors, and family support factors. Health workers need to consider these factors so that medication adherence among pulmonary TB patients will increase.

Staphylococus aureus is a major agent of bacteremia in children in African where malaria is endemic and always presented with the same symptoms. The main objective of this study is to determine the co-infection of malaria and Staphylococcus aureus bacteremia in children less than 5 years using standard procedures from a major secondary health center in Ilorin, Kwara State and determine antibiotics susceptibility of S. aureus. A total number of 235samples blood from febrile children suspected of having bacteremia were screened, 138 of the children were females and 97 were males. A total of 39 (16.6%) with positive blood culture was recorded in this study and Staphylococcus aureus bacteremia (SAB) detected is 20.5%. Age distribution of bacteremia were 14.3, 17.4, 27.3, 13.5 and 14.3 % for children in the age group ≤1, 1-2, 2-3, 3-4 and 4-5 years respectively while SAB distribution were 24.4, 12.5, 22.2, and 66.6 for children in the age group 1 month-1, 1-2, and 4-5 years above respectively. Also, a total number of 148 (63%) have a positive malaria parasite test, co-infection of malaria and bacteremia detected in 18 children with 6 (33.3%) having SAB and malaria co-infection. Age distribution of co-infection of malaria and SAB were 33.3, 50, and 25% with no co-infection recorded in age group 3-5years. A total of 2 (25%) methicillin resistant Staphylococcus aureus were isolated. Antibiotic sensitivity profile shows that 62.5% of S. aureus were resistance to cefuroxime, 80% to cefepime and 100% sensitivity to augmentin, linezolid, teicoplanin, ofloxacin, gentamicin and vancomycin. Age is an important risk for development of SAB and prompt treatment with a suitable antibiotics is required to reduce mortality associated with bacteremia.

Background: Prevalence of anxiety and other mental disorders have increased in medical health care workers during the Covid-19 Pandemic. Aim: To assess the anxiety among health care professionals during sampling for COVID-19 and its assessment via RT-PCR technique. Material and methods: A questionnaire based online survey was carried out on 134 health care workers including Dentists, Doctors and Nursing officers. The Questionnaire had demographic details and a set of 11 questions that analyzed the anxiety during various phases of sampling. Results: Out of 134 participants, 61.9% were males and 38.1% were females. The mean age of the participants was¬¬¬¬ 25.34 years. The anxiety among the health care professionals while undergoing sampling for covid-19 via. RT-PCR technique was found to be high. Conclusion: The anxiety among the health care professionals undergoing sampling for Covid-19 with RT-PCR technique was high considering the invasiveness of the nasal, the fear of getting a positive result for COVID and fear of acquiring infection from personnel/patients in the waiting hall. Post vaccination trials can possibly help in evaluating the change in anxiety among the various Health Care Workers (HCW’S) on receiving the COVID report.

Feminism refers to the social theory and political movement created and launched to end sexism, sexual exploitation, sexual discrimination and sexual oppression. In literature, feminist criticism mainly focuses on how gender influences the creation and interpretation of literary works, and its topics include discrimination, stereotype, objectification, body, oppression and patriarchy. In this paper, using Feminist Theory and Text Analysis to explore the heroine Jane Eyre ,who has the emotional entanglement with Rochester. Jane Eyre dare to pursue love, fighting against unfair rules, presenting the real image of women, who is the classic symbol of western awakening feminist consciousness, gradually women start to fight, to pursue their own rights and interests. In a word, the purpose of this study is to improve the status of women today, promote the full play and all-round development of women's, and at the same time help change the inequality situation between men and women, promote people to live in harmony and stable society.

Objective: was to take stock of the screening and treatment of precancerous and cancerous lesions of the cervix in the health district of commune V of Bamako in Mali. Patients and Methods: This was a descriptive, cross-sectional, analytical study with retrospectiveand prospective data collection over a period of 08 years from 1 January 2010 to 31 December 2017. Results: From January 1, 2010 to December 31, 2017, 42492 women were screened on a target of 174777 women, a frequency of 24.30%. The median age of women screened was 32 years; 25% were under 25 years of age. A similar proportion were over the age of 40. 3/4 of the women screened belonged to the age group of 20 to 49 years. Women aged 55 and over were the least represented by 5.7%. Screening coverage was over 35% among the 25-49 age groups. It was 31.9% and 23.1% among women aged 50 – 54 and 55 – 59 respectively. Screening coverage was less than 15% among 60-year-olds and older. Of the 22842 women screened, 90.1% had a normal cervix at IVA/IVL. However 4.1% cervix positivity to acetic acid and 5.1% positivity to Lugol. 0.7% of the women screened had clinically cancerous lesions. At the anatomo-pathological level, various histological lesions have been observed with regard to precancerous lesions, squamous cell carcinoma and adenocarcinomas. Indeed, among the women screened 96.5% had a normal cervix with benign lesions. For those with pathological histological results, 2.6% of them had histology with precancerous le sions and 0.8% had squamous cell carcinomas. A low rate of 0.1% of adenocarcinoma was recorded in our series. Conclusion: The improvement of screening indicators with IVA/IVL which does not require large resources is a promising avenue in Africa on which, it can hope for the rate of morbidity and mortality by cervical cancer.

Context: This study was planned to find out the depression, anxiety & stress levels among first year medical students of AIMS, B.G.Nagara. Aim: This study was conducted to determine the depression, anxiety & stress levels among first year medical students of AIMS, B.G.Nagara. Settings and Design: The present study was a cross - sectional study consisting of 150 first year medical students of AIMS, B.G. Nagara. Materials and Methods: This study was conducted in Adichunchanagiri institute of medical sciences, B.G. Nagara, Nagamangala Taluk, Mandya district, after the institutional ethical clearance and written consent to participate was taken from each student. Depression, anxiety & stress levels were assessed using Depression, anxiety and stress scale (DASS 21) questionnaire. Results: The DAS levels thus recorded were analyzed for statistical significance using. Data analysis was done using SPSS software version 19. Conclusion: The results of this study indicate that Depression, anxiety & stress levels was higher in first year medical students.

The purpose of this study is to analyze and find The Weaknesses of the Police's Discretion in Handling Minor Crimes in Indonesia Currently and How Is the legal Reconstruction Of Police Discretion In Handling Minor Crimes Based On The Values Of Justice. The method used in this study is a normative-juridical approach that uses a constructivist paradigm. The results of the study shows that the Weaknesses in Implementing the synergist Regulations of police discretion in handling minor crimes in terms of legal substance is that the discretion can be used as an engineering tool of the police apparatus to obtain personal benefits from the cases it handles. Weaknesses from the aspect of the legal structure can lead to the practice of abuse of authority. The weakness of the legal culture aspect is that the creation of formal justice creates public distrust of law enforcement officers so that in this case the police must be careful in applying discretion. Based on this, it is necessary to reconstruct the law on the value of police discretion in handling minor crimes based on justice in Article 18 paragraphs 1 and 2 of Law Number 2 of 2002 so that in resolving conflicts that occur between perpetrators and victims can achieve justice.

The purpose of this study is to analyze and find weaknesses in the regulation of the synergistic implementation of the duties of the National Narcotics Agency (BNN) and the National Police (POLRI) in Narcotics Cases and how to reconstruct the law on the synergistic implementation of the duties of the National Narcotics Agency and the National Police in Narcotics Cases based on the Value of Justice. The method used in this study is a normative-juridical approach that uses a constructivist paradigm. The results of the study indicate that the weaknesses of the Synergy Arrangement for the Implementation of the Duties of BNN and POLRI are that they have not been regulated in the realm of the Act or other statutory regulations. However, at least in article 70 c and article 84 the regulation of the authority of the BNN and POLRI has been regulated but in need of communication factors, proper recruitment of investigators, and rules that do not overlap, therefore Reconstruction is required in Law Number 35 of 2009 Article 70c; By adding the word "mutually" Coordinate with the Chief of the Indonesian National Police in prevention and eradication. "And synergize in every activity related to both". Then in Article 84; wherein conducting investigations into the abuse and illicit trafficking of Narcotics and Narcotics Precursors, the investigators of the Indonesian National Police shall notify in writing of the commencement of the investigation to the BNN investigators and vice versa, "And carry out work synergies by both". By adding the word synergy, it means that there are efforts that bind the occurrence of good cooperation in the form of an MOU between BNN and the Police.

The relationship between investment and shares is established to find the intrinsic nature. It is found when the best labour is 6 the cost is low and the number of shares are 1000 with the intersection of 1~4 RMB which is net profit point. When the best capital is 6 units the profit will be 5 RMB and the profit point is 1400 of the number of shares with the 5 RMB. The profit may become the positive at 780 pieces when the best labor is one. It explains that beyond this point the total net profit may be 3~4 Yuan may be best net profit in average profit. TR£2TC that says the Tpro may be best start because TCquan£0 in intersection between Tpro and TC. The total profit will be 3~4 Yuan according to the best labor and capital. The best labor is 1 whilst the best capital is 6 in this condition. In total TR³2TC is the valid value to make more profit which is concluded in this paper.

We report the case of a 46-year-old patient with a history of multifocal tuberculosis (peritoneal and pericardial) treated with anti-tuberculosis drugs and corticosteroid therapy for 12 months. He presented with progressive onset right heart failure syndrome during the course of his treatment related to chronic constrictive pericarditis documented by transthoracic ultrasound and right heart catheterization. The treatment was surgical by decortication with favorable operative consequences. This observation aims to question the rapid evolution of tuberculous pericarditis to chronic constrictive pericarditis usually described in the literature as a rare complication and occurring very late after several years.

The gifted education is an old field for America and for France which tackled the special education needs for gifted students with researchers whose concepts of mental age and intelligence testing transformed the standards of the psychological science. Thus, the United Arab Emirates (UAE) is still considered premature in this field where minimal attention has been granted to the gifted education area, which is a division of special education. This study aims to explore how inclusive is a British school (BS) in Dubai (UAE) for gifted students, by critically analysing its gifted education policy practices, through the framework of a case study. In order to investigate how inclusive is a British school in Dubai for gifted students, the researcher critically analysed its gifted education policy practices, compared to gifted policy international standards, through a qualitative research approach with a content analysis method. The Findings revealed that the British school gifted policy has few gaps compared to Purcell and Eckert’ standards. Few recommendations were written by the researcher to be provided to the British school educational stakeholders to improve the gifted policy and to enhance the gifted students’ conditions at school.

Homework is defined as a work allocated by the teacher to be accomplished by the student outside of the regular school day. The purpose of this study is to identify the effects of homework on the student academic achievement by conducting a descriptive study of selected and related existing literature the year 2000 to date. The gathered data failed to demonstrate that homework is an effective way to enhance the student academic achievement, in most cases.

This research was conducted to identify and map existing policies related to efforts to protect and fulfill the Sexual and Reproductive Healthcare Right (SRHR) of women in relation with Goals 1 (No Poverty), Goals 3 (Healthy and Prosperous Life), Goals 4 ( Quality Education) and Goal 5 (Gender Equality) of the SDGs, through services that are the obligation of the Local Government of East Lampung Regency. By using legal, otherwise known as empirical-sociological research methods, it is found that the SRHR and SDG are two different entities but both have similarities in Human Rights (Human Rights), namely related to, Socio-Cultural and Economic Rights. As a form of public service in the context of Human Rights, the East Lampung Regency Government is obligated to fulfill by legalizing various regulations and providing types of services, poverty alleviation, healthcare, education, and gender equality, to overcome stunting, child marriage, maternal and infant mortality, and violence against women, in East Lampung Regent. In the context of human rights, local government obligations are subject to the progressive realization which is carried out using the Human Rights-Based Approach (HRBA). So that they contribute in the form of a policy brief for the Regional Government of East Lampung Regency in realizing the SDGS issue and Fulfillment of Women's SRHR. Local government obligations are subject to the progressive realization which is carried out using the Human Rights-Based Approach (HRBA). So that they contribute in the form of a policy brief for the Regional Government of East Lampung Regency in realizing the SDGS issue and Fulfillment of Women's SRHR. Local government obligations are subject to the progressive realization which is carried out using the Human Rights-Based Approach (HRBA). So that they contribute in the form of a policy brief for the Regional Government of East Lampung Regency in realizing the SDGS issue and Fulfillment of Women's SRHR.