Abstract: Ocular drug delivery to the scientists is a fascinating field because of challenges and exquisite barriers encountered in the ocular milieu. Till now, non-invasive approaches in ocular delivery are not yet successful with respect to intervention/treatment of long term ocular diseases. In spite of adverse effects with invasive techniques, they have been demonstrated promise in the treatment of sight threatening complications. The use of intravitreal injections or intraocular implants is gaining momentum with paramount progress in design, safety and efficacy from last two decades. Various intravitreal injections and ocular implants were developed with a wide array of therapeutic application potentials targeting drug localization for an extended period of time. Miniaturization of implants for their direct injection eliminating surgical process is currently being explored. In this review, various modalities comprising these invasive techniques targeting posterior ocular tissues namely retina and vitreous humor are summarized.

The fishing community is fisherman patorani community that specifically captures the parent and fish eggs "Torani" (flying fish). The fishing community estimated patorani born since the 17th century and operate locally around the Sulawesi Sea, and catch fish species Torani and even other fish species. Since the birth until the early 20th century are still relying on the screen (Sombala) as a boat towing machine and rely on wind power. This study focused on social change traditional fishermen to fishers patorani. This study used qualitative methods descriptive, and data retrieval preliminary observation, interviews and documentation. Informants consisted patorani fishermen, boat owners and owners of capital. The research found that social change occurs due to the internal state of the orientation of the needs and dynamics of the owners of capital, while externally caused by the influence of the market on the fishing community by promising greater income and special one species of fish and fish eggs Torani. Changes it, then forcing the fishermen to make fundamental changes include a shift in social relations that were once family-oriented and then turn to the professional relationship and the contractual and binding.

This study aimed to highlight on the influence of exposure to electromagnetic fields (EMFs) on the cardiovascular system in humans and experimental animals, from the recent articles regarding the cardiovascular effects of exposure to EMFs. EMFs might produce a variety of adverse in vivo effects such as heart problems, chest pain, and cardiovascular system disorders. Previous studies showed that an association between elevated magnetic field exposure and mortality of employer in electric utility industry jobs from arrhythmia-related causes and acute myocardial infarction influence heart rate variability by changing autonomic balance. EMF exposure can affect structure and function of cardiovascular system and may facilitate myocardial infarction by nuclear changing of cardiomyocytes. Exposure to EMFs induced pain or pressure in the chest area, heart palpitations, and/or an irregular heart beat. The symptoms resemble a heart attack and thus contribute to even more anxiety. Also, exposure to EMFs caused highly significant increases in the activeties of serum creatinine phosphokinase, lactate dehydrogenase and aspartate amino-transferase enzymes, and decreases in plasma calcium level and total anti-oxidant capacity. Rats exposed to EMF showed increases in blood pressure, the absolute and relative whole heart and left ventricular weights. On the other hand, the heart rate was significantly reduced in rats exposed to EMF.

Tasting salt or Monosodium Glutamate was invented by the Japanese over a century ago. The flavour profile known as Umami, or the fifth taste, after the four tastes of sweet, salty, sour and bitter, was discovered whilst working with sea weed. Umami is a meaty taste that is naturally present in cheese and ripe tomatoes. For more than a 100 years, the flavour of Umami has been artificially manufactured in factories all over the world, starting in Japan. The flavour profile presented by tasting salt offers both packaged and non-packaged food producers with an affordable and openly accessible alternative to flavouring their foods. Home cooks are also offered the product as they are able to openly purchase the salt off the shelf. Hence, a lack of regulation. Presently, tasting salt is present in thousands of food items all over the world, and its use is only increasing. Restaurants use the salt in their dishes as an inexpensive alternative to building complex flavour profiles using meat stock. At the same time, health concerns about the product‟s wide spread use have also been made apparent over the last two decades. Despite the legal system of almost all countries in the world not having put any restriction on tasting salt, the use of the product has been shown to lead to serious health concerns for humans. Hence, the need for ethical business practice to promote public health by going above and beyond legal compliance.

Odontogenic keratocyst (OKC) characterized by a single lesion, with greater frequency in the mandibular jaw. The diagnostic approach is based on a combined analysis of the medical history, the clinical appearance and the radiographic appearance. The diagnosis may be confirmed by the anatomical pathology report. Finally, treatment consists of surgical excision and follow up is characterized by a high rate of recurrence. The authors report an unusal case of OKC of the upper jaw and review the various diagnoses and therapeutics.

Information plays a key role in helping the recovery of patients of alcohol and drug abuse (ADA). In the rehabilitation centres, ADA patients are engaged in a treatment programme and are expected to integrate back to the society and become productive people. Alongside other medical procedures, information plays an important role in helping in the recovery of patients of alcohol and drug abuse. This study aims to evaluate the access and use of information services to patients of alcohol and drug abuse in Nairobi County, the case of Asumbi Treatment Centre and to suggest ways in which they can be enhanced. The objectives of this study were: to determine the information needs ADA patients in the rehabilitation centre; to establish information seeking habits of ADA patients; to find out how ADA patients use information; to assess the existing information services available to ADA patients; to find out the challenges faced by ADA patients in accessing and using information, and to suggest ways of enhancing provision of information services to ADA patients in rehabilitation centres. This research adopted a case study design and the approach was mixed, having both qualitative and qualitative approaches. The findings revealed that ADA patients have their unique information needs and they experience challenges of accessing and using information. The study identified inadequate facilities for ADA patients to access and use information services in the rehabilitation centre. Among the major recommendations in this study is that ADA rehabilitation centres should establish information centres, and in addition, offer bibliotherapy services to its patients.

The significance of effective leadership and management for the successful operation of schools and colleges has been increasingly acknowledged in the 21st century. The trend towards self-management in the United Kingdom and in many other parts of the world has led to an enhanced appreciation of the importance of managerial competence for educational leaders. Today, leadership is seen as central and essential to delivering the changes, improvement and performance that community increasingly expects of all organizations including schools. The changing manner of school management has undoubtedly created reforms in the field of education with change expressed in the evolution from exterior supervision of school work to the empowerment of school’s staff, principal’s and teacher’s roles. This study was initiated to look into the leadership style among school principals in governing school systems in Peninsular Malaysia. Secondary data consisting of various leadership styles used in administering teachers, transformational and transactional leadership and the correlation between leadership styles and organizational variables, relationship between value systems and school principal’s principles were performed. Numerous researches have highlighted the fact that leadership behavior is a predictor of its efficacy and leads to the examination of leadership evolution. In this study, leaders with a high moral value system tend to lean towards a transformational leadership style in governing school systems in Peninsular Malaysia and acknowledges a positive correlation between leadership styles and value systems in school administration.

Primary Squamous cell carcinoma of the gallbladder is extremely rare and constitutes 0.5- 3% of all gall bladder malignancies. We report a 50-year-old female who presented with vague symptom of right upper quadrant pain. She was operated on a presumptive diagnosis of chronic cholecystitis according to clinical and ultrasonography findings. Histopathological examination showed an infiltrating mass of the gallbladder which revealed well differentiated keratinized squamous cell carcinoma invading full wall thickness. Thorough evaluation revealed no other primary site for the tumor. Pure primary squamous cell carcinoma of the gallbladder is very rarely reported. Clinicians must be aware of its vague clinical presentations.

Education has been directly equated with the overall development process of any human society. Basic or primary education being the foundation, is necessary not only for the sake of basic literacy and numeracy, but because it prepares children or human for future challenges. The more adequate and qualitative the primary education is given to children, the more equipped and industrious the children would become in the future. Therefore, good administrative planning and provision of primary level of education is crucial in achieving educational development. This paper examines Universal Basic Education (UBE) as a programme designed to provide primary education, outline it`s policy thrust and nature of implementation as well as assessing the ways through which the scheme can tackle the educational challenges facing the country, for an achieved sustainable development. Secondary data was used comprising the UBE documents and various litratures written by scholars on education and development in order to analyse and assess the relationship between basic (primary) education and sustainable development in Nigeria.

In current competitive environment of the construction industry, continuous quality improvement is becoming a need of the day. One important tool for continuous quality improvement is PDCA cycle (plan, do, check, and act) which can be effectively used for quality improvement and subsequently improvement in the performance by the construction firms. The objectives of the study were to identify the extent to which the firms are utilizing the PDCA cycle, and its effects on the firm performance in the context of small scale construction firms in the Kingdom of Saudi Arabia. Measure were adapted from previous sources to develop a survey questionnaire and through convenience sampling, responses were generated from staff from 20 selected small scale construction firms (n=157). Descriptive statistics indicate that the level of utilization of PDCA cycle among the sample firm is moderate level. Further, the three stages of PDCA cycle including plan, do, and act is having positive and significant effects on the firm performance. Based on the findings, it is recommended that small scale construction firms should focus on greater utilization of the PDCA cycle.

Antimicrobial resistance became a growing public health problem in the world and sexually transmitted infections (STIs) are one of the five types of pathologies which special care should be given. Staphylococcus aureus appear the most prevalent bacteria encountered causing infections in male urethral discharge (MUD) at Cotonou in Benin. It prevalence and it resistance to antibiotics were evaluated. This paper aims to describe the bacterial profile and antimicrobial susceptibility of S aureus strains isolated from MUD specimens at the National Laboratory (NL) of Heath Ministry. A retrospective study included 81 men at Cotonou suspected MUD during 1st January 2004 and 31st December 2015. MUD swabs were collected and analyzed to identify the bacteria by standard biochemical reactions, screening of trichomonads and detection of intracellular Gram-negative diplococci within phagocytes. The three main pathogens encountered among 81 MUD were Staphylococcus aureus (30/81; 37.04%), Staphylococcus spp (19/81; 23.46%) and Staphylococcus dore (12/81; 14.81%). S aureus susceptibility ranged from 60- 80% for minocyclin, lincomycin, chloramphenicol and gentamycin. But resistance was observed to ofloxacin, kanamycin, amoxicillin, amoxicillin-clavulanic acid, oxacillin, ceftriaxon, tetracyclin, trimethoprim+Sulfonamides and ampicillin between 59-100%. Conclusion: This study highlights the importance of routine susceptibility tests to antibiotics in the treatment of S aureus responsible of MUD in Benin.

There are various grafting materials used for socket preservation of the alveolar ridge following tooth extraction. The purpose of this study was to evaluate clinically and histomorphometrically healing after tooth extraction with or without placement of a synthetic bone graft and determine the effect on alveolar ridge preservation following extraction. 30 subjects in need of extraction of non-molar teeth were recruited for this study. Recruited subjects were randomly assigned to the group A (with graft material) or control (without graft material) group B. Data were recorded at 6 months after socket preservation procedures. At 6 months, a surgical re-entry was performed; Clinical Measurements and bone core biopsies were obtained for histomorphometric analysis. The control group B had a mean reduction in ridge height of 1.26mm, whereas alveolar ridge height in the test group A was 0.73mm. The test group A was 7.33 ± 1.01 mm compared to 7.23 ± 1.13 mm in group B which were not statistically significant (p = 0.684). Histomorphometric analysis revealed total new bone volume in group A represented 65.6 ± 11% connective tissue 25.6 ± 10.18 % and 8.8% was occupied by residual graft material. The mean new bone volume in group B was 31.23 ± 7.24%, whereas connective tissue formation was approximately 68.78 ± 7.24 %. Both these values were statistically significant when compared with group A. There was no relation with residual graft material as there was no graft material used in group B. A positive response was observed when synthetic graft was applied to extraction sockets, suggesting that it may be useful for preservation of ridge height prior to dental implant placement.

Scientific discoveries put forth new trends in the education during modern times. These trends influenced all aspects of human society. Scienticism is considered modern day religion, ideology and are more relevant and applicable for contemporary society. The perception, all matter being composed of small, indivisible particles called atoms is the base of matter, from which every object has its existence. From its earliest in the second century of the hijra, kalam has always been enthralled with the theory of atoms. In this paper an attempt has been made to discuss, elaborate and analysis with certain divergence the issue of atomism. The broad theory was generally endorsed by both the Mu‟tazilite‟s and Ash‟arites and their views, difference of opinion on the said issue, along with other medieval Muslim Scholars will be discussed at length. Their concept about the role of atom in matter formation in early Muslim scholar writings will serve the base for this paper.

This research paper analyses the impact of knowledge creation process on Mauritian business from a case study perspective. The knowledge creation process is a dynamic one since it comes from diverse areas. Firstly, the university or any training institution develops business courses that would help students benefit from job opportunities in firms which expected them to apply their knowledge at work. On the other hand, the knowledge creation process might come from the firm that urges the graduate to develop his knowledge and capabilities that should directly impact on the business. There is also a new approach whereby the university develops courses by integrating the student with the industry in a programme tailor-made for the organisation. This paper states that knowledge creation process should be developed in a dynamic way that integrates and addresses business needs in today‟s fast changing environment. Through a case study approach in three selected situations, using Nanoko‟s Taxonomy of knowledge creation as a framework, it reveals that the knowledge creation process is a two-fold dynamic practice and that its success depends on the inter-relationship between tacit and explicit knowledge.

The main objectives of the study are to further explore the connection between conceptual metaphor and the language expression structures through the comparative analysis of the conceptual metaphor in the commencement speeches of universities between English and Chinese. It also studies the meaning, cultural characteristics, similarities and differences of the two languages so that it can give a proper interpretation of how the cultural factors works on the language structure and semantic expressions. The conceptual metaphor was regards as a system of human conceptualization. Speeches addressed on graduation ceremonies by great people who are admired by the university students play a vital role in their lives. So the comparative study of conceptual metaphor in Chinese and American commencement speeches is necessary.