Abstract: The antimicrobial resistance among gram negative bacteria is increasing among patients, community and healthcare workers. Determination of these species and their resistance profile is mandatory for successful empiric antibiotic therapy. The aim of the current study was to investigate the prevalence of drug resistant gram negative isolates from community and healthcare workers in Iran. A total of 10 previous published studies were found while searching internet searching engines including PubMed, Google scholar, Sciverse, and so on. The key words of “gram negative”, “drug resistant”, “healthcare workers”, “community” and “Iran” were searched in the noted searching engines. The publications related to the healthcare, patients and hospital settings were excluded from the study. Moreover, healthcare workers of children and adults/ageing and in addition, community settings were included in the study. Data were analyzed with Exel software. Among the published studies, most of bacterial species among healthcare workers and community were in Enterobacteriacea family, mostly E. coli (3.75%) and K. pneumonia (3.74%), A. bumanii (3%), P. aeruginosa (1.25%), E. aerugenes (1.2%), Proteus spp (0.1%) and other species. Two publications were about caregiver’s mobile phones and 2 were associated with hands. Moreover, community and workers hands were more contaminated than phone and coats. The results showed that community and healthcare workers can play a role in contamination spread. Hands of healthcare workers were the highest level of contamination. The publications on MDR isolates were scarce.

Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have an adverse effect on health, leading to reduced life expectancy and/or increased health problems. WHO estimates traditional medicines, mostly plant drugs cater to the health needs of nearly 80% of world population. The aim was to study the influence of Trigonella foenum-graecum seed powder on the basic parameters of obesity induced by hight calorie diet. We included 40 male rats and divided them to 4 groups of 10 animals in each group. Normal rats (groups 1, 3) were fed by a standard chow, while the others (groups 1, 4) were fed with high-caloric diet during 14 weeks. From week 15 to 18, groups 2 and 4 were treated with Trigonella foenum-graecum seed powder (Fg). Liver function markers were estimated by biochemical analyzer Microlab 300 and commercial kits from Elitech diagnostic according to the standard protocols provided by manufacturers. The serotonin content was determined in brain using ion-exchange chromatography and fluorescence methods. We have shown that consumption of high-calorie diet leads to changes in food behavior and the development of obesity in rats. Treatment of obese rats with Trigonella foenum-graecum seed powder leads to normalisation of key physiological and biochemical parameters. Treatment with Fg significantly suppressed the increments of body weight, fat weight. Fg improved lipid levels. These results demonstrated the treatment effect of Trigonella foenum-graecum seed powder on the basic parameters of obesity induced by hight calorie diet.

Abstract: The prevalence of lifestyle diseases or the Non-Communicable Diseases (NCDs) are on the rise colossally as well as globally. The key contributors are understood to be the pollutants and contaminants present in local ambient environment that trigger the onset of cellular oxidative stress i.e. imbalance in levels of oxidants and antioxidants at cell level, and the pro-inflammatory changes. Reports in literature indicate a possibility of association between risk of increase in lifestyle-disease-incidences and the acquisition of clinical vulnerability (ACV) in subjects chronically exposed to pollutants. Occurrence of oxidative stress is known to be the first and foremost change for the onset of NCDs. Therefore a periodic assessment of imbalance in levels of oxidants and antioxidants is plausible that can be performed by determining levels of cellular oxidative damage and the Total Antioxidant Capacity (TAC) in blood or body fluids. Elucidation of subnormal TAC can provide an opportunity for protection from ACV or getting predisposed to diseases and disorders through evidence based timely supplementation of antioxidants. In this review, we hypothesize, and appraise, the utility and significance of TAC measurements as a public health tool for monitoring ACV. Its measurement at different levels of NCD prevention shall result in efficient implementation of global action program for control of NCDs burden. Points in approval are ease, reliability, specificity, reproducibility, and the inexpensiveness of the method. We also contend that further research could lead to development of a proper cocktail of antioxidants to be used as adjuvant therapeutic measures to delay or reverse existing NCDs and their impact in individuals. We propose TAC as an early indicator that can be used to detect and control ACV and related NCDs.

Plants form the main ingredients of medicine in traditional system of healing and have been the source of inspiration for several major pharmaceutical drugs. In spite of great advances of modern scientific medicine, there is a rapid increase in the use of alternative medicine worldwide. To investigate the effect of the aqueous root extract, Methanol and n-Hexane root fractions of Curcuma longa Linn on Alloxan Induced Diabetic Rats. A total of thirty-six (36) rats were used and were grouped into six (6) groups of six (6) rats each. Group I served as normal control, group II served as diabetic control, Group III rats were induced with diabetes and administered with standard drug (Metformin, 100mg/kg) while Groups IV, V and VI were induced with diabetes and administered with crude aqueous extract, methanol and n-hexane fractions respectively at a dose of 400mg/kg body weight for four weeks. The research found that the methanol fraction showed highest potency with a significant (p<0.05) decrease in blood glucose level when compared to diabetic control after few days of fraction administration, it was followed by the aqueous extract which also shows hypoglycemic activity a week after administration. N-hexane fraction showed a marked hypoglycemic activity only after about two weeks of administration with the fraction. The present study demonstrated that the methanol fraction possesses the highest hypoglycemic activity.

Abstract: The Aim of the study was to ascertain contraceptive awareness in Saudi women of Hail region and to reveal their knowledge with respect to their specific socio demographic factors. Cross sectional survey (n=500) conducted in reproductive age Saudi women of Hail region. Sample population was approached by direct interview by undergraduate medical students and questionnaire shared by social media. Questionnaire included their age, education, knowledge, use of any method and contraceptive preferences. 500 Saudi women of Hail region were approached from 15 to 55 years. Most women (82%) interviewed were highly educated up to university level. 47% of respondents were young 25 to 34 years of age, 31 % were 35 to 44 years. 93% of women were familiar to contraception before but 77.8 % used it ever in their lives. A good percentage of women (88.0%) used it without prescriptions. 71.2% get this information from media (social, print and broadcasting media), 68.8% from discussion with relatives and same percentage were educated by their doctors. Oral contraceptive pills are the most familiar method while other methods need to be publicized. 55.2% of respondents feel that their knowledge about different contraceptive methods is not enough and they urged on the need to provide more awareness and education about this. There is a great need to create more awareness about different methods and their appropriate use in Hail region. Health professionals as well as social media should be involved in this education and motivation.

Indiscriminate usage of Cassia occidentalis in treating many diseases has been locally practiced, the need for ascertaining the epicacy of the extract in management of liver and kidney damage become imperative. This research investigate the effects of aqueous root extracts of Cassia occidentalis on some liver and kidney parameters in acetaminophen induced liver and kidney toxicity. A total of thirty five rats were used for the research, in phase I, ten rats were used to confirm the inducement of hepato-renal toxicity by acetaminophen. They were grouped into two of five rats each, group I serve as normal control, group two serves as test control and administered with 750mg/kg body weight of acetaminophen. The animals were euthanized after 24 hours of acetaminophen administration and liver function indices (ALT, AST, total protein, Albumin total and direct Bilirubin) and kidney function indices (urea and creatinine) were assayed. In phase II, twenty five rats were grouped into five groups (GI – GV) of five rats each. G I served as normal control, GII served as test control, GIII, GIV and GV were induced with hepato-renal toxicity and administered with the extract at a dose of 50mg/kg, 100mg/kg and 150mg/kg body weight per day for two weeks. A significant increase (p<0.05) in both liver and kidney function indices was observed in test control group compared to normal control in both phases. Administration of the extract lead a significant decrease (p<0.05) in liver parameters in a dose dependent manner compared to test control. Contrary to this however, a slight decrease in serum urea and creatinine was observed in the extract administered groups. The observed hepatocurative ability of the plant may not be unconnected with the presence of various phytochemicals in the plant.

This research investigates the sensitivity of female business owners/managers to ethical challenges and the effect on their success as female entrepreneurs in Akwa Ibom State, Nigeria. The survey design was used with study population consisting of 1,678 female owners of registered small and medium scale enterprises (SMEs) operating in Akwa Ibom State, Nigeria. From the population, random sampling technique was utilized to select a sample of 400 female entrepreneurs for the study. Data were obtained through the Multidimensional Ethical Questionnaire and were analyzed using descriptive and inferential statistics. Result showed that except in conflict of interest, relationship between moral equity, contractual obligation, and entrepreneurial success was positive and significant. Participants were found to be aware of what constituted ethical issues, and tended to act accordingly to minimize ethical challenges in the process of doing business. We recommended sensitization on the consequences of unethical business decisions to business and the larger society.

Radiographic imaging is essential in diagnosis, treatment planning and follow-up in endodontics. The interpretation of the 2-D images can be confounded by superimposition of both teeth and supporting structures and the geometric distortion that is present. These problems are overcome by cone beam computed tomography (CBCT) which produces accurate 3-D images which can be used for pre-surgical assessment. The spatial relationship of the specific tooth root(s) undergoing the surgical procedure (and the associated bony destruction) to adjacent anatomical structures can be precisely assessed. The radicular cyst arises from epithelial remnants stimulated to proliferate by an inflammatory process originating from pulpal necrosis of a non-vital tooth. Radiographically, the classical description of the lesion is a round or oval, well circumscribed radiolucent image involving the apex of the tooth. Radicular cyst is usually sterile unless it is secondarily infected. This case report presents successful management of an infected radicular cyst associated with a permanent maxillary left central incisor (21) in a 38 year old male by complete enucleation of the cyst and using platelet rich fibrin (PRF) and bone graft to fill in the bony cavity to hasten the healing.

This paper examined the barriers/challenges facing the evaluation profession in Nigeria and the role of the Nigerian Association of Evaluators (NAE) towards improving the profession. The paper also draws lessons from other African countries on how to improve evaluation practice in Nigeria. The findings indicate that paucity of evaluation skill, partial implementation of national monitoring and evaluation systems, lack of monitoring and evaluation ownership, nonutilization of evaluation results and funding are the main barriers/challenges confronting evaluation conduct in Nigeria. The paper therefore recommends that the NAE should improve the technical capacity of evaluation practitioners in Nigeria; organize workshop for cross learning and experience sharing among practitioners; supporting monitoring and evaluation ownership and canvass for utilization of evaluation results. The paper finds from cross country analysis that institutionalizing the evaluation of public polices is a veritable step towards a National Evaluation Policy in Nigeria, which will promote good monitoring and evaluation practice in the country. Overall, we recommend that policy makers in Nigeria should aim to use evaluation in improving the effectiveness of public policies.

Corynebacterium pseudotuberculosis is the causative agent of caseous lymphadenitis (CLA) in small ruminants. This study was designed to evaluate the efficacy of 0.5% and 1% formalin killed prototype vaccine of C. pseudotuberculosis in bucks and does. A total of 24 healthy bucks and does were equally divided into four groups of 6 animals. Groups A and B were vaccinated with 0.5% and 1% formalin killed prototype vaccine and groups C and D were kept as positive (+) and negative (-) control groups, inoculated with plain vaccine adjuvant. After booster vaccination at the 6th week, groups A, B and C were experimentally inoculated with 2mL of 106 cfu of live C. pseudotuberculosis subcutaneously. On the 12th week, all animals were euthanized and samples of reproductive organs and pituitary glands of both bucks and does were collected. Bacterial isolation and identification was done on the basis of morphological characteristics and PCR detection. Based on the bacterial culture results, 3 samples each were Positive for C. pseudotuberculosis colonies from bucks in groups A and B, while 4 samples were positive from does in group A and only 1 from does in group B. All bucks and does from groups A and B showed negative PCR amplifications in all samples. This study showed that 1% formalin killed prototype vaccine of C. pseudotuberculosis is effective in preventing the spread of the bacteria to the reproductive organs and pituitary glands of both bucks and does. Thus, it will be a suitable preventive measure against CLA in small ruminants.

In the present study, a series of N-[6-fluoro-7-substituted-1,3-benzothiazol-2-yl]-4-[2-(3-nitrophenyl)-4-oxo-thiazolidin-3-yl]benzenesulphonamide and N-[6-fluoro-7-substituted-1,3-benzothiazol-2-yl]-4-[2-(4-nitrophenyl)-4-oxo-thiazolidin-3-yl]benzenesulphonamide derivatives were synthesized in good yields and characterized by FTIR, 1HNMR, mass spectral and elemental analyses. All synthesized compounds were evaluated for their preliminary in vitro anti-mycobacterial activity against Mycobacterium tuberculosis H37 Rv strain by tube dilution assay method. Some selected synthesized compounds were also evaluated for cytostatic activities against malignant human cell lines: cervical (HeLa), bone marrow (K-562) and kidney cell (HEK-293)

Abstract: This study aimed to analyze the influence of company image and service quality on customer loyalty through customer satisfaction in the environment laboratory PT. Nusantara Water Centre Jakarta. Data research conducted on selected customers during the period from April 2016 to November 2016. The study design is descriptive, where the method of sampling is done by purposive sampling (sample representative of the population). From the number of customers per month around 400 customers, the number of respondents that were sampled set by 161 respondents Method of quantitative analysis using confirmatory factor analysis by using SEM tools Lisrel software version 8.71. The results showed the company image has a positive significant effect on customer satisfaction, service quality has a significant positive effect on customer satisfaction, company image has a significant positive effect on customer loyalty, and service quality has a significant positive effect on customer loyalty and satisfaction significant positive effect on customer loyalty. Quality of care is the most dominant variable toward service loyalty.

Drug related adverse effects may be minor or major. Pharmacists have an ethical obligation to notify the appropriate bodies whenever adverse effects where suspected. Stroke affect one’s physical and communication abilities, as well as causing emotional changes and difference in behaviour. The study underlines the importance of monitoring stoke survivors emotional and behaviour alternation. The objective is to determine the drug utilization review in post stroke patients and to assess the adverse reactions in stroke management. Cross-sectional prospective study was performed for six-month and the patients diagnosed as stroke and wished to participate were identified. All the subjects were evaluated for adverse drug reactions through telephonic or face to face interview. Out of 52 patients 71.15% were males and 28.84% females. The mean age of the patients was 63.21 (±10.19) years and 61% patients had Blood Pressure, followed by 55% Dyslipidymia, 42% Diabetes Mellitus. A total of 38 incidences of ADRs were observed during the study period for 15 patients. The highest reported ADR was GI bleeding (17.3%) followed by GI Distress and Constipation. Causality of ADRs found to have probable 74%, possible 23.6% and definite 2.6% and no doubtful categories. The study results cleared that majority of the stroke patients have adequately severe neurological impairment and need assistance to carryout activities of daily living. Majority of the patients seems to have mistaken the symptoms of ADR to be due to the disease being treated and old age. Drug utilisation studies should be carried out in large number of population and at different locations which helps to reduce the drug related problems and improve the rational use of drugs by the patients.

Abstract: As observed in Nigeria presently, both the Gross Domestic Product (GDP) and unemployment rates are increasing simultaneously. This occurrence however, invalidates the existence of Okun’s Law in Nigeria. In the same vein, Nigerians output could as well be more capital intensive to labour intensive. This research work sets out to finding the reason for the violation of Okun’s Law in Nigeria. Using Weighted Grouped Logit Distributed lag model (WGLDL) with quarterly series from 1991 to 2012. Present quarter and last-two quarter unemployment rates are negatively related with the present quarter Real Gross Domestic Product of Nigeria. The immediate past quarter unemployment rate is positively related with the present quarter Real Gross Domestic Product by approximately 16 units rise in RGDP for a unit rise in the immediate past quarter unemployment rate. This is a result of behavioural habits of employees; when people are retrenched from their jobs last quarter, the efficiency, effectiveness, and output/productivity of the remaining workers increase indefinitely as the means to retain their jobs in the midst of the fear and job insecurity that have enveloped them. This they do on the axiom that the less or least effective and efficient workers were retrenched last quarter. Consequently, a positive relationship. Empirically, the probabilities that the national output will fall for every raise per quarter unemployment rates diminishes and tends to zero. Simply put, the failure that unemployment will result to reductions in the national output is almost certain (tends to one). In the same light, change in probability also tends to zero as unemployment rates in Nigeria increases. This therefore suggests, holding every other thing constant, increase in unemployment rates in Nigeria will probably not affect or reduce our National output.

Derivatives of 7-substituted-8-amino-3-methylxanthines is a promising group of substances for synthesis and pharmacological screening in order to create diuretics, for pharmacological correction of the kidneys, on their basis. The acute toxicity and diuretic activity dependence on the chemical structure for the first synthesized 7-substituted-8-amino-3-methylxanthines in experiments on rats was investigated. 3-Methyl-7-(2-hydroxy-3-p-methoxyphenoxy)propyl-8-(2-furyl)methylaminoxanthine, increases urine excretion at 201.3% and is higher in the diuretic effect comparing to hydrochlorothiazide up to 111.3%.