Taking cost-effective and efficient medical and wellness care at a beautiful location while enjoying a great vacation is profound as medical and wellness tourism. The medical and wellness tourism sector can play a decisive role in the growth of the economy, GDP, employment, and foreign exchange earnings of any country in the world. Unani medicine is one of the oldest traditional systems of medicine being practiced in many countries, including India, under the patronage of the Ministry of Ayush, Govt. of India. The principles of treatment employed in the Unani system are four-branched, which include dietotherapy, regimenal therapy, pharmacotherapy and surgery. Of them, the first three modes may be practically applied in the establishment of medical and wellness tourism centres in Unani medicine. Due to its holistic approach, this system of medicine has high potential for the treatment of many chronic ailments, viz., osteoarthritis, liver diseases, vitiligo, obesity, psychosomatic disorders, etc., to name a few, through its unique detoxification therapy called regimenal therapy. Various regimenal procedures, viz., cupping, hirudotherapy, irrigation therapy, etc.; many modified diets, like barley water, honey water, etc.; and certain special pharmacotherapeutics, such as munḍīj va mushil (concoctive & purgative) therapy and muqwaviyyāt (tonics), are useful for the treatment of various illnesses. Incorporation of these detoxification regimens, dietetics, and drug therapy may exert a significant influence on the outcomes of cosmeto-therapeutics, rejuvenation of mind, neuro-rehabilitation, etc. These are some of the core areas where the Unani system may play a stellar role in boosting medical tourism. Hence, the Ministry of Tourism in collaboration with the Ministry of Ayush may devise such ways and means to further strengthen the already existing Unani medical and wellness centres to attract foreign as well as domestic tourists for their healthcare issues.

This study involves the use of the histology of the mantle of a periwinkle species, Tympanotonus fuscatus, as a biomarker tool, to investigate and evaluate the ecological pollution status of two different water bodies, Bodo and Creek Road water-sides, in River State. The study involved the sampling of ten (10) feral table sized fish from two stations along the creeks of the experimental sites (Bodo and Creek Road water bodies), with similar specie, size and number from a reference site (ARAC – African Aqua-culture Centre). The test fish mantles were harvested from the fish caught from both experimental sites for histological evaluation, while the control mantles were harvested from fish harvested from ARAC. The percentage prevalence of histological alterations showed that fish from Bodo water-body had the worse outcome (25%), followed by Creek Road water-body (21.7%) and ARAC having the best outcome (6.6%). mantle histology has proven to be an explorable biomarker for evaluation of environmental status.

The development of resistance to various antimicrobial agents by bacteria, fungi, viruses, and parasites poses a major challenge to the medical field in treating the infections they cause. Consequently, there is an urgent need to explore new and innovative antimicrobials. A promising solution lies in the use of natural products, such as essential oils, as antimicrobial agents. Herbs and essential oils have been used since ancient times in various aspects of life, including perfumes, cosmetics, agriculture, and industry. In medicine, these essential oils have demonstrated numerous applications, such as analgesic, anti-inflammatory, antioxidant, fungicidal, and antitumor activities. Essential oils present a viable alternative to synthetic chemicals due to the presence of biologically active compounds, such as phenols and terpenes, that inhibit or prevent pathogen growth. This review paper aims to explore the importance of essential oils, their components, and the mechanisms they use to combat pathogens. It will also highlight their role as a potential solution to multidrug resistance and discuss future prospects.

Immune cell activation is a feature of COVID-19, that leads to cytokine storm which causes neurotoxicity, neuroinflammation, and neurodegeneration, related to psychiatric symptoms due to the depletion of neurotransmitters, dopamine, serotonin, norepinephrine, GABA, and glutamate which play a major role in adult neurogenesis. ACE2 receptors are expressed in the hippocampus and decreased neurogenesis in this region is a major factor behind the neuropsychiatric disorders. SARS-CoV-2 can affect the brain indirectly through neuroinflammation and altered neurochemical signaling and even mild COVID-19 infections can lead to sustained microglial activation, which disrupts neural networks and impairs cognitive function. The long COVID-19 may be associated with cognitive dysfunction in those who recovered and immunological response may affect synaptic pruning and reduced anterior cingulate cortex volume at one year after COVID-19. Post-acute sequelae of SARS-CoV-2 infection or PASC, commonly known as Long COVID is a significant public health concern and "brain fog" is one of the most debilitating cognitive impairments, affecting memory, concentration, and executive function occurring in 88% of cases. Brain fog may be linked to persistent changes in neurotransmitter levels, particularly involving dopamine and serotonin which play an essential role in cognition, attention, and emotional regulation. Elevated levels of pro-inflammatory cytokines, the chemokine CCL11, is linked to cognitive impairments in patients with persistent symptoms. Neuroprotective agents that support neuronal health, such as antioxidants and mitochondrial enhancers and noninvasive brain stimulation techniques such as transcranial magnetic and direct current enhance cortical excitability are investigated in cognitive recovery. Evaluation of the currently predominant VUM (a Variant Under Monitoring), LP.8.1, and the most recently designated NB.1.8.1, is increasing as 10.7% of global sequences reported recently due to minor mutations in spike protein. In May 2025, TAG-CO-VAC (Technical Advisory Group on COVID-19 Vaccine) advised that the monovalent vaccines targeting against JN.1 or KP.2 lineages are highly appropriate.

Hormonal contraceptives (HCs) are widely used for birth control. There are reported adverse effects associated with HCs and liver and kidney function in people on hormonal contraceptives. Limited studies exist to establish these reports; it is however crucial to elucidate any potential associations between these medications with liver and kidney dysfunction. This study aims to evaluate the impact of hormonal contraceptives on liver and renal function. For this study, a total of 50 participants were used; 25 of the total participants are women of reproductive age, using hormonal contraceptives, while the other 25 participants are women of reproductive age, not using hormonal contraceptives. The participants were recruited from Orita-Obele and Arakale health centers, Akure, Ondo State. The results showed a significant increase (p<0.001) in both creatinine and urea levels when compared to the control, but no significant increase (p>0.05) in both sodium and potassium ion concentrations. A significant increase (p<0.0001) in aspartate aminotransferase (AST), alanine transferase (ALT) activity, along with a significant increase (p<0.01) in bilirubin level, were observed in the case when compared with the control group. The results suggest that the alterations observed in kidney and liver function of subjects on hormonal contraceptives may indicate potential impairment. Understanding these interactions is crucial for ensuring the safe use of hormonal contraceptives and managing any potential risks to liver and kidney health, thereby guiding clinicians in prescribing these medications and monitoring their effects.

Background: This study aimed to examine the relationships between anthropometric characteristics and physical fitness performance among adolescent male football academy players in Bayelsa State, Nigeria. Understanding these associations could inform player development and training strategies in youth football. Methods: A cross-sectional analytical design was used to assess 20 male football players aged 15–25 years. Anthropometric variables measured included height (170.62 ± 3.16 cm), weight (62.95 ± 1.92 kg), waist-hip ratio (0.83 ± 0.01), body fat (%), and limb lengths. Fitness attributes evaluated were speed (40-m sprint), agility (Illinois agility test), endurance (Yo-Yo test), flexibility (sit-and-reach), core strength (plank test), and power (standing long jump). VO₂max was estimated using the Siri equation, with Body Density derived from the Jackson and Pollock 3-site formula. Results: The players demonstrated moderate agility (17.87 ± 0.20 sec), sprint speed (5.71 ± 0.06 sec), and VO₂max (35.25 ± 6.12 mL/kg/min). Notably, goalkeepers’ height and VO₂max were perfectly correlated (r = 1.000, p = 0.008), and lower limb length significantly correlated with VO₂max (r = 1.000, p = 0.030). Midfielders' lower limb length strongly predicted sprint speed (r = 0.886, p = 0.019). Other correlations across positions were weak or not statistically significant. Conclusion: Anthropometric traits, particularly limb lengths and height, significantly influence select aspects of physical fitness in football players, varying by playing position. These findings support tailored conditioning programs based on player morphology.

This paper examines Imbolo Mbue’s How Beautiful We Were through the lens of the Integrated Model of Ideological Representation in Discourse (IMIRD) to explore how environmental risk is communicated as a tension between silence and resistance. Developed by Ogungbemi (2016), IMIRD synthesizes the ideological depth of Critical Discourse Analysis (CDA), the structural precision of Systemic Functional Linguistics (SFL), and lexical analysis to investigate how language encodes power, agency, and ideological positioning. Applying this model, the paper analyzes transitivity structures, agency assignment, and discursive silencing in Mbue’s depiction of a fictional African village devastated by corporate oil pollution. Through a close reading of narrative voice, clause structure, and dialogic framing, we demonstrate how Mbue’s linguistic choices—such as collective narration, passive constructions, and high-transitivity clauses—represent the villagers’ oscillation between voicelessness and defiant resistance. The study reveals how narrative grammar functions as a site of ideological struggle: one where corporate actors are obscured or backgrounded, while subaltern voices struggle for recognition. Ultimately, we argue that How Beautiful We Were is not only a literary account of environmental injustice but also a compelling discourse of resistance, showing how storytelling—when examined through IMIRD—operates as a vehicle for reclaiming agency, memory, and ecological justice.

Background: Numerous secondary metabolites present in plants, such as tannins, terpenoids, alkaloids, flavonoids, and glycosides, have demonstrated antibacterial properties in vitro. Increasing data on the antibacterial properties of medicinal plants are emerging globally. These plants generate secondary metabolites with antibacterial properties, providing an alternative for developing chemical fungicides that are both relatively safe and cost-effective. Coleus aromaticus, a member of the Lamiaceae family, possesses bitter, aromatic, digestive-stimulating, stomachic, anathematic, deodorising, diuretic, and hepatoprotective properties. Aim: The aim of current investigation is to reveal the mechanisms of C.aromaticus leaf bioactive in treating fungal infection. Methodology: Scientific validation of the current investigation was done by computational based molecular docking study of selected lead molecules against 1,3β-Glycan synthase enzyme. Result: The molecular docking results indicating binding energies of -4.02, -6.81,-4.24 and -5.18 kcal/mol for chlorogenic acid, quercetin, rosmarinic acid and rutin respectively. Conclusion: The findings indicated that each selected lead chemical for additional investigation shown significant inhibitory activity against 1,3β-Glycan synthase, hence revealing its anti-fungal potential.

This study examines biometric identification system as a step towards better crime control in Cameroon, with particular interest to fingerprint biometrics, DNA identification, facial recognition as well as their respective data bases. Cameroon’s biometric identification system is a government initiative aimed at enhancing identity management, security, and access to services through the use of biometric technologies. Fingerprint biometrics, DNA identification and facial recognition technologies are used in Cameroon for crime control. Their respective databases are, however, not well developed but for AFIS (Automated Fingerprint Identification System), adopted by Cameroon government as a centralized biometric identification system for managing and authenticating identity documents. International governance on the use of biometrics for crime control has also provided Cameroon with a framework to incorporate the following in its biometric identification system: human right protection, standardization and best practices, accountability, and cross-border crime and cooperation. Legal and institutional frameworks exist that aid in biometric data collection and storage. While biometric identification systems have significant potential for crime control in Cameroon, their current effectiveness is moderate, hampered by infrastructural, legal, and operational challenges. Strengthening legal frameworks, improving infrastructure, ensuring ethical use, and fostering interagency collaboration are essential steps toward maximizing the benefits of biometric technologies in promoting security and justice.

To determine if targeted exercise could reduce overweight and obesity in schoolchildren, a 12-week study was conducted with 60 randomly assigned participants. One group (n=30) received an enhanced exercise intervention, consisting of two extra athletic training sessions per week in addition to their regular physical education. The control group (n=30) continued with the standard curriculum and twice-weekly physical education. Key measurements, including height, weight, waist circumference, body fat, and BMI, were taken as outcome measures. After 12 weeks, the exercise group showed significant improvements in all measured outcomes (p<0.05), indicating the program's success in combating overweight and obesity.

Beginning Syntax: An Introduction to Syntactic Analysis aims to present the basic concepts of syntactic theory to readers without requiring prior linguistic knowledge. Starting from the ideas of modern generative linguistics, the author systematically introduces basic concepts and the latest developments in linguistic theory in a step-by-step fashion. Topics covered include Phrase Structure Rules, X’-theory, Wh-movement Rules, Universal Grammar, Movement Parameters, and the Architecture of Grammar. The book explores multiple perspectives in natural languages, emphasizing the relationship between linguistics and cognition, society, and politics. It highlights the importance of formal and cognitive theories, treating language as a program running on the hardware of the brain and positioning syntactic theory at the core of cognitive theory. Chapters One through Six provide a detailed exposition of the foundational knowledge in syntax, while Chapter Seven expands the explanatory scope of Generative Grammar. It describes the distribution of word order features of world languages and proposes the wh-movement parameter hypothesis, offering the necessary analysis for understanding Parameter Hierarchies. Then, it systematically introduces the five components in a particular overall grammar model. The publication of this book is considered a milestone, as it utilizes the Parametric Comparison Method to analyze universal patterns and diversities in world languages. It develops Chomsky’s (2005) theory of parameter differences related to the third factor in language and Greenberg’s (1963) hypotheses on language universals and word order typology. The book focuses on providing scholars with in-depth foundational knowledge in syntax, inspiring thoughtful consideration of deep-seated issues in language structure.

Coeliac disease (CD) is an immune mediated enteropathy caused by the ingestion of gluten in genetically predisposed individuals. It is frequently associated with wide spectrum of extra-intestinal manifestations, including thromboembolism events. We report the case of a young woman known with a CD since the age of 6, who says to be compliant to the gluten free diet (GFD), and presented with bloating and anemic syndrome. The endoscopic and anathomopathological examinations revealed no abnormalities. The CT scan revealed incidentally a chronic obstruction of the inferior vena cava (IVC). the etiological work-up for thromboembolic disease was negative, concluding to a Budd-Chiari syndrome complicating her CD. She was managed with anticoagulants, specifically Direct oral anticoagulants (DOACs).

Bone marrow invasion in pediatric solid tumors is an essential area of research, as it has a significant impact on prognosis and treatment strategies. Bone marrow metastases occur when non-hematopoietic malignant cells infiltrate the bone marrow, often leading to severe hematological disorders and high mortality rates if not identified early. The mechanisms of bone marrow invasion involve tumor cells escaping into the bone marrow, forming micrometastases which can then take on aggressive forms. Bilateral bone marrow aspirates and trephine biopsies (BMAT) are essential for accurate classification, as discrepancies in results can occur. In addition to their progressive nature, pediatric solid tumors are characterized by a high metastatic potential, particularly in the bone marrow. This retrospective study analyzes a series of 52 cases of solid tumors with bone marrow invasion, diagnosed in the hematology laboratory and pediatric hemato-oncology unit (UHOP) of the Hassan II University Hospital in Fez over a six-year period, from January 2016 to December2022. Evaluation of bone marrow involvement is a key factor in therapeutic orientation and assessment of response to treatment. The presence of bone marrow metastases is associated with a poor prognosis. The haematology-biology laboratory plays an essential role in detecting extra-haematopoietic cells suggestive of bone marrow metastases, over and above standard tests. Despite advances in our understanding of spinal cord metastases, challenges remain in early detection and effective treatment, necessitating ongoing research to improve outcomes for affected children. In this article, we review the epidemiology, molecular mechanisms, clinical diagnosis, treatment and prognosis of bone marrow invasion in solid tumors in the pediatric population.

Against the backdrop of national policies advocating for the integration of ideological and political education into college courses and the strengthening of Chinese cultural dissemination globally, this paper aims to explore effective strategies for incorporating the narration of China’s stories into the College English curriculum. Focusing on North China Electric Power University (Baoding), the study employs a combination of teaching practice and a questionnaire to investigate the current status, pathways, and methods of integrating China’s stories in College English instruction. The research findings reveal that the integration of China’s stories in class teaching enhances students’ cross-cultural communication abilities and deepens their understanding of Chinese culture. The study highlights the feasibility of merging language learning with cultural narrative and calls for expanded extracurricular practice and long-term impact research. These findings offer practical insights for college English curriculum innovation and cultural soft power enhancement.

Schwannoma is a benign peripheral nerve sheath tumor originating from Schwann cells. Its occurrence in the tongue is rare. We report the case of a 19-year-old patient presenting with a painless, slowly enlarging mass on the mobile portion of the tongue. MRI revealed a well-defined, encapsulated lesion. The mass was completely excised surgically, and histopathological examination confirmed the diagnosis of a benign schwannoma. The postoperative course was uneventful, with no recurrence observed during follow-up.