Medicinal plants have been used with practical implementation of certain herbal great source of plant based flavonoids, antioxidants compounds. Medicinal plants were traditionally used for health care and serve as the bases for the emergence of modern medicine. They have possess the high quality of the extracts to evaluate their therapeutic efficacy for their pharmacological action. Large variety of medicinal plants have been used as aromatic purposes and hence valuate for aroma and pharmacological sectors. Medicinal plants snowed stronger binding to the proteins secreted by the parasitic worms thus inhibiting them to proliferate in the cellular tissues thus acting as main source of immunity booster to the living tissues against the dyspepsia, gastritis, hyperacidity, menorrhagia, diabetes. Saraca asoca also used as source of medicinal pant due to its to antibacterial activity because of its potential against the of multiple bacterial strains. Some of the medicinal plants acting as dual nature such as targeting the microbial proteins and peptides playing important role in the development of natural therapies. Nanoparticles based therapies can be utilized for treatment of infectious diseases.

Introduction: Hysterectomy is a surgical procedure commonly performed in obstetrics gynecology at the Sominé Dolo hospital in Mopti, but no study had been conducted. The aim of this study was to determine the prevalence of hysterectomy and to review gynecological and peripartum hysterectomies. Methods: This was a descriptive cross-sectional study conducted over a period of 12 months from January 1, 2017 to December 31, 2017 in the obstetrics gynecology department of the Sominé Dolo hospital in Mopti Mali. Eligible patients were represented by all those who had undergone a peripartum or gynecological hysterectomy during the study period in our service. Our supports consisted of patient files, patient interviews, the operating report register, the delivery register and the hospitalization register. Data were entered and analyzed using Epi info3.5.3 software and word processing was performed using Word 2007 software. Results: During the study period, all the surgical interventions represented 522 cases, i.e. an overall prevalence of 9.2% (57/522) among which hysterectomies during the gynecological period represented 70% (38/57) against 30% (19/57) peripartum hysterectomies. The average age of the patients was 46.5 years with the extremes of 18 and 75 years. The types of hysterectomies were represented in the vast majority by total interadnexal hysterectomy 77.2% (44/57) followed by subtotal hysterectomy 15.8% (9/57) and hysterectomy plus bilateral adnexectomy 7% (4 /57). Conclusion: Hysterectomy is one of the most practiced surgical activities at the Sominé Dolo hospital in Mopti. It constitutes an alternative solution for the practitioner to save the life of the patient, particularly in the event of emergency hysterectomies which represented a significant proportion in our study.

Background: Carbon monoxide is produced in abundance in the Niger Delta, a fact that was acknowledged in the World Bank study of the region in 1995 and the Environmental assessment of Ogoni land by UNEP in 2011. Objectives: To ascertain the extent of CO pollution in the Niger Delta, its impact on foeto-maternal health and to review the pathophysiology and the treatment of the poisoning. Methods: A mixed method study (observational-descriptive and systemic review). A literature review on the above objectives was carried out. The known foeto-maternal impact of CO exposure was extrapolated to the prevailing state of CO pollution in the Niger Delta. Questionnaires distributed to Doctors working in the tertiary Centres in the core Niger Delta focused on the prevalence, clinical presentations and foeto-maternal findings in patients who presented with CO poisoning. Results: There was no data on the prevalence and clinical presentations of CO pollution in the Niger Delta. The ambient and indoors air concentration of CO in the Delta range from 0 ppm to 191μg/m3 but in places within 60-200 metres from crude oil flow stations, the concentrations range from 100 to 5320 μg/m3. Maternal impact of CO pollution ranges from headaches at carboxyhaemoglobin (COHb) levels of 5-20% to maternal death at COHb levels of >66% while in the foetus, it causes birth defects, growth restriction, prematurity and sudden intrauterine and early neonatal death. Conclusion: The core Niger Delta is under perpetual siege of CO pollution and the ambient and indoors air concentration of it in the Delta range from 0 ppm to 191μg/m3.

Styles were used by different authors to ensure a proper channeling of messages from their novels to the targeted readers. Balaraba Ramat Yakubu who is among the few reputable Hausa women authors combined the position of mother, elder, leader, and responsible married woman. At the time she strived hard to acquire what can sustain her family and relatives she wrote many Hausa fiction books in which she depicted her wisdom and opinions in exposing the need to have a decent society base on her life experience, a society that respects women dignity, display honesty, discipline and promote a violent free society and encourage respect for one another. Balaraba Ramat Yakubu has tried to symbolize some of these issues in her books as her contribution towards sustaining responsible society in Nigeria, Africa, or the world at large. Styles as used by authors is a toolbox in the manipulation of their talents to expose their mission in their works. Balaraba Ramat used her styles to display her opinions on how different dimensions of our lives should be. This paper analyzes how Balaraba Ramat Yakubu addressed some of these issues and analyzes them. The paper used her Hausa novels and the academic works done on them and other things related to her. The paper, however, makes contact with both primary and secondary sources for further justifications. It however concludes with the findings that in Hausa society, men remain behind their wives in whatever they do to earn their lively hood as long as their strives do not contradict Islam and Hausa culture. Again going by the power of the pen, the paper also encourages writers especially women to use their pen as their powerful weapon to fight all forms of insurgency which rendered hundreds of thousands of women and children victims of circumstances in many African countries.

Researchers in recent years are working on different approaches to the problem of bacteria resistant to antibiotics through drug modification. The synthesis of metal drug complexes are becoming more popular than their parent drugs because they possess modified pharmacological, toxicological and physiochemical properties. In this study, amoxicillin complexes of copper and zinc (II) ions were synthesized using standard method. The complexes were characterized for aqueous solubility, UV-visible spectral, acid stability, and thermal stability and in-vitro antimicrobial activities. The results of the physiochemical properties showed evidence of complex formation between the metals and the ligand. The acid and thermal stability of amoxicillin complexes showed high acid and thermal stability than its parent form. In-vitro antimicrobial activity of amoxicillin and its complexes form were studied against Staphylococcus aureus and Pseudomonas aeruginosa. The results revealed that Amoxicillin complexes of copper (II) ions showed effective antibacterial effect on Staphylococcus aureus than its pure form while Amoxicillin Zn2+ showed lower antibacterial activity when compared to its parent drug. This study suggests that transition metal complexes of amoxicillin modify the properties of the parent drug.

The aim of this study was to investigate the effect of task and environment manipulation on the performance of selected basic motor skills. For this purpose, 30 children aged 4 to 6 years were selected using the available sampling method. First, the pre-test of over hand throwing was performed using the accuracy of throwing and kicking, and then the participants were randomly divided into 3 groups: manipulation of task restraints, environment constraints, and control. According to the research plan, the intervention groups performed the program for 6 weeks and two 60-minute sessions each week. The task constraint group practiced according to the task ecological analysis method, the environment constraint manipulation group practiced in the based on enrichment of the environment and the control group had no activity. After the last training session, a post-test was performed and the results were recorded. The data were analyzed with analysis of covariance test and Bonferroni was used for paired comparisons. The results showed that there was a significant difference between the remaining mean scores of kicking and over hand throwing of the subjects in terms of group membership (experimental and control groups) (P <0.05). Also, the results of Bonferroni post hoc test showed that the groups of manipulation of task constraints and performance environment had better than the control group in the studied skills, but the difference between the two groups was not statistically significant (P <0.05). The finding generally support and provide an insight into the idea of the effect of constraints manipulation on performance. Therefore, when teaching and working with children, manipulation of task constraints and environment can be used to improve the performance of children's fundamental movement skills.

The study looked at what is preventing IDPs from returning to their normal house in Maiduguri, Borno State. The study's specific objectives were to assess IDPs' rights regarding relocation to their usual home of residence, examine the implications of insufficient funds for rebuilding IDPs' usual home of residence, examine the implications of insecurity on IDPs' relocation to their usual home of residence, and finally assess the effect of insecurity on IDPs' relocation to their usual home of residence. Primary and secondary sources were used to compile the data. The respondents were given a questionnaire to fill out as part of the primary data collection. A total of 400 people from Maiduguri were surveyed. The study looked at a variety of ideas, with human needs theory serving as the study's theoretical framework. The idea covers the essential cause for IDPs returning to their customary place of residence in order to alleviate the difficult circumstances faced by IDPs who have lost their homes, jobs, and families, among other things. Food, shelter, healthcare, education, and clothing are among the basic needs of IDPs. The findings revealed that Internally Displaced Persons have the right to relocate to their usual home of residence and the right to request and receive protection. The study further revealed that Internally Displaced Persons have the right to humanitarian assistance from national authorities without discrimination and the right for assistance in restoring family link, Health care, education, and economic and social rehabilitation are all things that need to be addressed. The findings also stated that due to a lack of funds, the funding for restoring IDPs' customary place of living is insufficient. It was discovered that returning IDPs are frequently attacked by militants in their homes and are frequently kidnapped by the group. It recommends that the Borno State governments should enact a local law in the State to compel IDP’s management agencies at all levels to stringently observe the U.N. Guiding Principles on the protection of the right of Internal Displacement on relocation to their settlement. The Nigerian Government should fight corruption and ensure a direct link between the management agencies and the IDP's. Contingency plans should be made financially and bureaucratically in anticipation of displaced events to accommodate the rapid nature of displacement, the bureaucratic process involved in the release of finances and other resources for the administration of IDPs should be simplified.

With the popularity of international communication and cooperation, the transformation from general English to general academic English has become an inevitable trend in college English teaching in China. The transformation poses challenges for college English teachers, including the lack of interdisciplinary knowledge, limited general academic English teaching ability and evaluation ability. Accordingly, various measures can be taken to deal with the challenges, such as expanding the interdisciplinary knowledge, establishing the teaching community and reforming the evaluation means. These strategies are intended to construct the harmonious education ecology in college to promote the transformation and development of college English teachers.

Background: Antibiotic stewardship aims to optimise restricted antibiotic use and thereby prevent the emergence of antibiotic resistance and improve treatment outcome. Resistance to conventional antimicrobial’s is a major reason why restricted antibiotics are prescribed. Aim: To assess the prescribing pattern of restricted antibiotics, the indications for which restricted antibiotics were prescribed, the drug related problems associated and the sensitivity pattern of the isolated organisms. Results: Out of 340 patients included in the study, majority of patients was in the age group of 58-67(60.06 ±14.90) in both genders. There was a male (64.12%) dominance observed in the study populace and the minimum and maximum age observed was 18 and 93 years respectively. Most commonly prescribed antibiotic was Piperacillin tazobactum (31%) followed by Linezolid (16.06%). Empirically the most prescribed antibiotic was Piperacillin tazobactum (27.37%) while in definitive therapy it was Cefepime tazobactum (10.63%). The most common indication for which restricted antibiotics prescribed were for respiratory tract infection (n=116), followed by infection prophylaxis (n=114). Mean days of restricted antibiotic therapy was found to be 8.85 days ± 8.11. The maximum duration of antibiotic treatment was 62 days and minimum was 1 day. In 47% of cases IV to oral conversion was possible. When analysed retrospectively, in majority of the patients the duration of restricted antibiotic treatment was inappropriate (69.71%) while the inappropriateness in frequency and dose were 7.05% and 3.23% respectively. The total number of cultures collected were 292 in that 120 cultures were urine and found growth in 50.83%, followed by 84 cultures in sputum which accounted for 67.85% growth. The most common organism isolated was Klebsiella pneumoniae 39.73% cases followed by Pseudomonas aeruginosa 17.46% and Acinetobacter baumannii15.41. There was clinical cure in 91.47% of cases. Conclusion: When analysed retrospectively majority of the restricted antibiotics showed inappropriateness. This higher amount of inappropriateness could have been avoided to a certain extent, by the timely interventions of a clinical pharmacist. By implementing an effective antimicrobial stewardship program we could improve the rational use of restricted antibiotics and thereby prevent the future resistance and improve clinical outcome.

experience by including computers and the internet in the learning process. It is a system for delivering learning materials to students via the web. These systems include assessment, student tracking, collaboration and communication tools. They can be accessed both on and off-campus, meaning that they can support students' learning outside the lecture hall 24 hours a day, seven days a week. This enables institutions to teach not only traditional full-time students but also those who cannot regularly visit the campus due to geographic or time restrictions, e.g. those on distance learning courses, doing evening classes, or workers studying part-time and various leaning disabilities as well

Chondroblastoma is a rare, giant cell -rich benign neoplasm of bone. Fine needle aspiration cytology (FNAC) is gaining acceptance as a convenient and reliable method in preoperative diagnosis of chondroblastoma. Differential diagnosis of chondroblastoma on FNAC include giant cell-rich tumors and tumor like lesions such as aneurysmal bone cyst, giant cell tumor, chondromyxoid fibroma. Preoperative diagnosis of chondroblastoma is mandatory for treatment protocol and prognosis. We describe a case of 18 year old female patient who presented with painful swelling over right heel of one year duration. FNAC smears of swelling stained with Leishman and Giemsa stain showed neoplastic mononuclear chondroblasts showing round to oval nuclei, nuclear indentation, grooving and intranuclear inclusions with abundant vacuolated glassy cytoplasm, chicken wire calcification, multinucleated osteoclast like giant cells and chondromyxoid matrix. Histopathological examination of excised specimen revealed focal areas of mature cartilage with proliferating chondroblasts showing nuclear grooves and numerous giant cells. Thus confirming the diagnosis of chondroblastoma.

Piper guineense (uziza) leaves may have therapeutic input on male infertility caused by Lead exposure. This study investigated the antioxidant activities of the ethanolic extract of Piper guineense leaves (EEPL) on lead-induced testicular toxicity in rats. Twenty male wistar rats (150-200g) were divided into 4 groups consisting of 5 rats each. Control received 1ml of distilled water, lead only received 150mg/kg of lead, low dose received 150mg/kg of lead + 300mg/kg of EEPL, high dose received 150mg/kg of lead + 600mg/kg of EEPL. Administration was done orally for 14 days and then sacrificed. Blood was collected and analysed for serum testosterone and testes were harvested and homogenised for testicular antioxidant enzymes and zinc levels. Data was analysed for ANOVA using Graph Pad Prism 5. Lead exposure negatively affected the antioxidant enzymes, testosterone and zinc levels. Administration of EEPL significantly (p<0.05) increased the testosterone and zinc levels in a dose dependent manner. EEPL also significantly (p<0.05) increased the testicular Superoxide dismutase, Catalase, and Glutathione peroxidase levels and significantly decreased the testicular Malondialdehyde levels. Piper guineense leaves ameliorate testicular oxidative stress damage induced by lead toxicity.

Regional fiscal capacity is the region’s ability reflected in regional revenue, consisting of own-source revenue (PAD), fiscal balance transfers, and other legitimate regional revenues. This study aims at analysing the impact of regional financial capability during the Covid-19 Pandemic towards regional fiscal capacity. The research was conducted in local governments in Indonesia during 2020 using descriptive qualitative analysis. The results showed that generally the Covid-19 Pandemic affected the reduction on own-source revenue (PAD) in almost all provinces in Indonesia during the first semester of 2020. From 66 regencies/cities as the sample from this research, 49 regencies decreased in revenue and expenditure because of the Covid-19 Pandemic. The revenue reduction in each region was caused by regional taxes reduction of around 2,5 percent and 10,68 percent sequentially in the first semester of 2020, fiscal balance transfers around 8,42 percent, and general allocation grant (DAU) around 9,8 percent and 6,94 percent. Meanwhile, to solve the regional fiscal problems, the local governments implemented 2 types of policies: (1) the first policy is to implement a counter-cyclical policy through maintaining economic stability, decreasing revenues, and increasing local government expenditures; (2) the second policy is to implement a pro-cyclical policy through increasing revenues and decreasing expenditures. The present research also found that regencies/cities that implemented a counter-cyclical policy generally increased in expenditure components, such as grant expenditure around 316,51 percent and regional capital expenditure. Some local governments built infrastructure (assets and buildings) during the Covid-19 Pandemic. However, local governments decreased around -1% - 16% for the employee expenditures.

An increase in demand for concrete to meet global needs has been accompanied by an increase in global concerns due to an increase in demand for the non-renewable resources that are and comprise the constituents of concrete. To address these concerns and mitigate the impact of their depletion, researchers have investigated the intrinsic properties of a wide range of available materials and assessed their contribution when mixed with concrete. This paper presents the findings of an experimental study that was carried out to assess the structural response of concrete beams made with river gravel as coarse aggregate. Six reinforced beams (100 x 150 x 1100 mm) and six cubes were cast to investigate the specimens' flexural and compressive behavior. The failure modes, bending, and shear capacity were investigated in this study. According to the findings of the study, river gravel used as coarse aggregate in concrete has a roughly equivalent or slightly lower structural performance than conventional coarse aggregate, indicating the feasibility of river gravel as coarse aggregate for building construction.

Background: Practicing in trauma unit can strengthen nurses’ knowledge about the association of past trauma and the impact of trauma on the patient’s current mental illness. An aim of this debate is to avoid potentially re-traumatizing a patient during their episode of care. This educational discussion can provide nurses with content that describes the interplay of neurological, biological, psychological, and social effects of trauma that may reduce the likelihood of re-traumatization. Although multidisciplinary environments, the translation into clinical practice by nurses working in emergency departments (EDs) is unknown. However, before ED nurses can begin to practice, they must first be provided with meaningful and specific education about their role. Therefore, the aim of this debate was to evaluate the role and emergency management skills of ED nurses. Methods: This debate was conducted as exploratory research with a descriptive study design. Quantitative data were collected with an 18-item pre-education and post-education questionnaire. Results: A total of 34 ED nurses participated in this education discussion. There was meaningful change (p < 0.01, r ≥ 0.35) in 9 of the 18-items after discussion. The debate was based on the perceived effectiveness to evaluate the role and emergency management skills of ED nurses. Conclusion: Emergency department nurses became more informed of the interplay of trauma on an individual’s mental health. However, providing care to trauma patients in an ED setting was a considerable challenge primarily due to time constraints relative to the day-to-day. ED environment and rapid turnover of patients with potentially multiple and complex presentations. Despite this, nurses played a good role to reduce the likelihood of re-traumatization.