Traditional methods of wastewater treatment, in the past, have aimed at removing pollutants and compliance to regulations as a result of which have proven to be inefficiency and resource wastage. Nevertheless, growing demands of water scarcity, climate change, and requirements to adopt a circular economy have fuelled the shift into next-generation biological processes, which redefine the concept of wastewater as a resource, as opposed to a waste stream. This review assesses critically emerging paradigms in biological treatment that go beyond traditional activated sludge systems and incorporate the new developments in the fields of microbial ecology, synthetic biology and bioelectrochemical systems and nature-inspired engineering. Special focus is made on new microbial consortia, designed metabolic routes, and system-wide process advancement that allow the recovery of nutrients, generation of bioenergy, and the manufacture of value-added biochemicals in a better way. The article also assesses the role of hybrid biological systems in the treatment of wastewater under energy-neutral or energy-positive processes, including microbial electrochemical systems and algae-bacteria systems. The problem of techno-economic feasibility, operational resilience, and scalability are discussed systematically to reduce the gap between the innovation over the laboratory scale and its application in the real world. This article identifies the key gaps in knowledge, regulatory issues, and barriers to integration that may not be able to be easily adopted since they point to the recent advances in various fields. Finally, the review also provides a future-based structure of planning sustainable wastewater treatment processes in accordance with a circular bioeconomy, with future-generational biological processes being the core elements of the future water infrastructure in cities and industry.

Diphtheria remains a significant public health concern in India despite the availability of routine immunization. This survey-based review analyzes national surveillance data (2020–2024), WHO–UNICEF immunization reports, and responses from frontline healthcare workers to assess the current trends, antitoxin accessibility, and challenges in early diagnosis. Findings indicate a shift in disease burden from young children to adolescents and young adults, mainly due to waning immunity and low booster-dose coverage. Limited availability of Diphtheria Antitoxin (DAT), delays in procurement, and cold-chain constraints continue to affect timely case management across several states. Early diagnosis also remains difficult because initial symptoms resemble common upper respiratory infections, primary-care staff have limited training, and rapid diagnostic tools are not uniformly available. Overall, the survey highlights an urgent need for improved booster-dose coverage, decentralized DAT stock management, and stronger early-detection systems to reduce diphtheria-related morbidity and mortality in India.

Refinery wastewater has been causing environmental pollution with serious adverse health effects and environmental destruction. This study aims at evaluating the capacity of cassava peels and sugarcane bagasse biosorbents in removing heavy metals, and organic pollutants from the oil refinery wastewater. The proximate and minerals composition of the cassava peels (CP) and sugarcane bagasse (SCB) was determined using the method of AOAC. The pH, turbidity, biological oxygen demand (BOD), and chemical oxygen demand (COD) were determined using digital pH meter, turbidity meter, 5-Day BOD test, and colorimetric technique, respectively. The heavy metals, phenol, and total oil and grease (TOG) content was estimated using AAS and colorimetric method of AOAC. Batch adsorption test was conducted using completely mixed batch reactors (CMBR) method. The results showed that CP and SCB contain significant (p < 0.05) amount of ash (5.38 %, 2.15 %), fiber (20.63 %, 3.83 %), carbohydrate (7.87 %, 27.64 %), proteins (1.87 %, 1.42 %), moisture (1.20 %, 14.99 %), and lipids (2.52 %, 4.22 %), respectively. The CP (3.72mg/100g, 5.41mg/100g, 8.1mg/100g, 3.00mg/100g, 6.52mg/100g, and 4.26mg/100g) contain high significant (p < 0.05) amount of sodium, potassium, calcium, iron, zinc, and copper compared with that of the SCB (2.33mg/100g, 2.10 mg/100g, 5.40mg/100g, 1.88mg/100g, 2.09mg/100g, and 2.14mg/100g), respectively. The pH value of the wastewater sample treated with the biosorbents was significantly (p < 0.05) high compared with the pH value of the untreated wastewater sample. At significant (p < 0.05) reduction in turbidity, COD, and BOD was observed in the wastewater sample treated with combination of the biosorbents compared with the untreated wastewater. The wastewater sample treated with combination of the biosorbents demonstrated significant (p < 0.05) decreased in phenol and TOG content compared with the untreated wastewater. The biosorbents exhibited high removal efficiency against cadmium, lead, nickel, and chromium up to 65.70 %, 80.30 %, 52.46 %, and 72.70 %, respectively. The biosorbents displayed a methylene blue and Congo red dye removal efficiency of 85.66 % and 74.23 %, respectively. The R2 value of lead, cadmium, nickel, chromium, methylene blue and congo red dye for Langmuir isotherm model is higher than that for Freundlich isotherm model. Thus, the experimental equilibrium data for heavy metals and the dyes were best fitted to the Langmuir model than the Freundlich model.

Present research work was aimed to study preliminary wound healing activity of different extracts of aerial parts of Enicostema axillare using incision and excision wound models in experimental animals. Aerial parts of Enicostema axillare was extracted successively with petroleum ether, chloroform, acetone, ethyl acetate, methanol and aqueous solvents and obtained respective extracts. Each extract was tested qualitatively for detection of phytochemicals present in extracts using various chemical tests. Pharmacological screening of all extracts were performed using incision and excision wound models in experimental animals. Wound healing effect was observed by measurement of tensile strength of wound tissue of animals from incision model. Wound contraction measurement and biochemical estimation of wound tissue was performed in excision wound model. Results of present study was confirmed that methanol extract of Enicostema axillare was showed significant (P<0.05) increase in tensile strength of wound tissue on 9th day. Higher percentage of wound contraction was observed with methanol extract between day 8-16th and complete healing was observed on 18th day. This fast healing also supported by significant (P<0.05) increase in hydroxyproline and protein content of wound tissue in excision model. Effect was compared with the marketed formulation (Povidone-Iodine ointment). In conclusion, healing effect of methanol extract of Enicostema axillare may be contributed by phenolic compounds, flavonoids and glycosides present in the extract.

The study empirically examined the relationship between electronic payment system adoption and marketing success of Electricity Distribution Company in Port Harcourt, Nigeria. The population of this study comprises the customers of Electricity Distribution Company in Port Harcourt, Nigeria. There are 4,461,546 registered customers of Electricity Distribution Company in Port Harcourt (National Bureau of Statistics, NBS, 2025, www.nigerianstat.gov.ng). The researcher employed the Taro Yamen Formula to reduce the population to a reasonable sample size. The study has 4,461,546 customers of Electricity Distribution Company in Port Harcourt, which implies that the population of the study is known and cluster sampling technique, was therefore used to determine the sample size of 399 through the use of Taro Yamene’s formula. Multiple regression analysis was used with the aid of statistical package for social sciences (SPSS, version 21) analyze to the data. The study concludes that Based on the findings of the results, the study concludes that electronic payment system adoption strongly and positively relates with marketing success of electricity distribution companies in Port Harcourt as it creates a means of enhancing and increasing customer’s satisfaction which in-turn leads to customer loyalty. The study further recommends that, electricity distribution companies should ensure that e-wallet applications must always follow trends or developments in online consumer consumption patterns in Port Harcourt.

Quantum chemical study of some thiomethyl quinolines on inhibition of aluminium corrosion in hydrochloric acid and effect of thiomethyl group at 5,6 and 8 position on quinoline was investigated theoretically with the aid of material studio using density functional theory (DFT). The simulations were performed by means of the DFT electronic program DMol3 using the Mulliken population analysis in the Material Studio. DMol3 permits analysis of the electronic structures and energies of molecules, solids and surfaces. The analysis of the quantum chemical parameters, the adsorption parameters form the simulation of the molecules, the Mulliken and Hirshfeld values of the fukui indices for the three molecules of the 5-TMQ (5-thiomethylquinoline), 6-TMQ (6-thiomethylquinoline) and 8-TMQ (8-thiomethylquinoline) indicated that all the three molecules exhibits very high potential for inhibition of aluminium corrosion in HCl environment, with 8-TMQ being the best among all. The most popular parameters which play a prominent role are the eigen values of the highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO), the HOMO-LUMO gap (ΔE), chemical hardness and softness, electro-negativity and the number of electrons transferred from inhibitor molecule to the metal surface. All the molecules showed a very good corrosion inhibition tendency, however, 8-TMQ molecule gives better aluminium corrosion inhibition potential than other two molecules. The orientation of the thiomethyl substituent on the core quinoline was found to be responsible for intra-molecular hydrogen bonding which leads to weaker attraction to the aluminium surface for the 6-TMQ and 5-TMQ molecules hence lower corrosion inhibition tendency than 8-TMQ molecule despite having the same molecular mass.

Jalinūs (Galen), a Greek physician, writer, and philosopher, made significant contributions to the advancement of medical knowledge and conducted numerous dissections and observations of the brain and nerves, providing detailed descriptions of their structures and functions. His contributions to the nervous system anatomy and disease theory were significant, and he was the first to identify the brain as the site of termination for all five senses, which laid the foundation for further research into the functions of the nervous system. His theories on the nervous system were revolutionary, challenging prevailing beliefs and paving the way for further research, and his anatomical drawings and descriptions helped uncover the neuromuscular system under the control of the brain, as well as the structure and function of the respiratory and speech systems. Additionally, his studies on respiration and the recurrent laryngeal nerve solidified the idea that the brain is the site of rational power guiding human behavior. Furthermore, he differentiated sensory from motor nerves by palpation and believed the brain and nerves were responsible for sensation and thought. Jalinūs’ work on the nervous system, which included the vivisection of animals, laid the groundwork for future discoveries and advancements in the field. Despite these controversies, Jalinūs (Galen) remains significant and continues to influence modern medical practice. In this paper, we have reviewed the contributions of Jalinūs (Galen) to the advancement of knowledge in the anatomy of the nervous system.

Among the driving forces of sustainable economic growth in South Asia, digital financial inclusion has turned out to be one of the most powerful especially when we consider the fast technological change and huge growth of fintech ecosystems. This paper discusses how Digital Financial Inclusion (DFI) influences the sustainable economic growth of the South Asian countries such as India, Pakistan, Bangladesh, Sri Lanka, and Nepal that are the focus of this paper. The study follows a descriptive and analytical approach to research. It uses primary data that were collected from 275 respondents, and secondary data that were obtained from international databases such as the World Bank and International Monetary Fund. Regression and correlation analyses were carried out to assess the extent of association between digital financial inclusion indicators and sustainable growth indicators. The results indicate that Digital Financial Inclusion has a significantly positive effect on Sustainable Economic Growth (B= 0. 267, p < 0. 05). Moreover, the correlation results reveal a moderate positive correlation (r = 0. 452, p < 0. 01) between digital financial inclusion and the indicators of sustainable growth. The comparative analysis shows that countries with a higher adoption rate of digital payments, internet penetration, and financial account ownership have a better sustainability performance. Even though the explanatory power of DFI is limited, the paper verified through its analysis that digital financial ecosystems are enabling factors for entrepreneurship, SME expansion, employment creation, and poverty alleviation. The study argues that digital financial inclusion is one of the driving forces for sustainable development in South Asia but not its sole factor, thus highlighting the importance of complementary institutional and policy reforms.

Hybrid composite structures (e.g., carbon–glass laminates, fiber–metal laminates, and multi-material sandwich panels) offer superior stiffness-to-weight performance but exhibit complex, multi-mode damage mechanisms such as matrix cracking, fiber breakage, delamination, and interface debonding. These damage modes are often difficult to detect early and expensive to simulate at full structural scale with high fidelity. This paper proposes an integrated framework that combines multi-scale progressive damage simulation with machine learning (ML)–assisted damage inference and load optimization. At the microscale and mesoscale, damage initiation and evolution are captured using established composite failure criteria and degradation laws (e.g., Hashin-type mechanisms), while structural-scale response is computed using reduced-order surrogates calibrated from multi-scale results. On the data side, guided-wave/shock-response features and simulated strain-field descriptors are mapped to damage states using supervised and uncertainty-aware ML models. Finally, a load optimization module minimizes peak interlaminar stresses and damage growth rate under service constraints. A case study on a hybrid laminate panel demonstrates that the proposed pipeline can (i) identify early delamination and matrix cracking signatures with high classification performance, and (ii) reduce damage-driving stress metrics through ML-guided load redistribution.

Objective: This systematic review aimed to synthesize longitudinal evidence on the natural changes in orthodontic treatment need among children and adolescents, with a specific focus on identifying malocclusion traits that demonstrate a potential for spontaneous correction over time. Methods: A systematic search was conducted across PubMed/MEDLINE, SienceDirect, Cochrane Library and Google Scholar from inception to November 2025, following PRISMA guidelines. Eligible studies were longitudinal cohorts assessing children and adolescents in mixed or early permanent dentition, with no prior orthodontic treatment at baseline. Outcomes included changes in treatment need measured by indices like the Dental Aesthetic Index (DAI) or Index of Orthodontic Treatment Need (IOTN), and observed self-correction of specific malocclusion traits. Risk of bias was assessed using the Newcastle-Ottawa Scale. Results: Four prospective cohort studies (n=1,253 participants) were included. The evidence revealed a non-linear trajectory of malocclusion prevalence, characterized by an initial decrease from primary to mixed dentition, followed by an increase in early permanent dentition. Despite this, a net decrease in treatment need was observed for many individuals during the transition from mixed to permanent dentition, with one study reporting decreased DAI scores for 60.8% of children. High rates of spontaneous correction were documented for specific traits: anterior open bite (87-99%), Class II malocclusion (83%), and unilateral posterior crossbite (83%). Nevertheless, a persistent, clinically significant treatment need remained, with 22% of 11.5-year-olds classified as having severe or extreme need. Conclusion: Orthodontic treatment need in children is dynamic, not static. While significant self-correction occurs for traits like anterior open bite and posterior crossbite, a substantial proportion of children develop a definitive need for intervention by early permanent dentition. These findings underscore the importance of longitudinal monitoring and cautious timing of orthodontic assessments, particularly during mixed dentition when transient traits may overestimate true long-term need.

Breast cancer represents the most prevalent cancer type among women in Saudi Arabia. Despite the availability of early detection programs via mammography, participation rates remain suboptimal due to limited awareness and prevalent misconceptions regarding the screening process. This review aims to consolidate and critically analyze published studies examining the impact of health education on women’s awareness and knowledge of mammogram screening. Evidence indicates that structured health education interventions delivered in healthcare settings or through community campaigns and digital media significantly enhance women’s knowledge and encourage early detection practices. The findings underscore the necessity of sustained educational programs and active involvement of healthcare professionals, particularly radiologic technologists and nurses, to optimize breast cancer prevention and early detection.

Background: The external ear plays a significant role in clinical, surgical, and forensic sciences. Anthropometric data are essential for surgeries, hearing aid design, and forensic identification. Ethnic diversity influences auricular morphology, emphasizing the need for population-specific data. This study provides data on the Okrika tribe, exploring sexual dimorphism and applications in clinical and forensic practice. Aim: To establish anthropometric auricular parameters for the Okrika tribe, with potential applications in clinical and forensic contexts. Materials and Method: This descriptive cross-sectional study recruited 450 Okirika indigenes (245 males, 205 females) aged 18+ years with no ear abnormalities or previous surgeries. Digital vernier calipers measured ear length, width, lobular length, and lobular width on both ears. Measurements were taken with subjects sitting upright and head in Frankfort horizontal plane. Data were analyzed using R programming environment, with sex differences assessed via independent sample T-test and correlations with stature via Pearson's/Spearman's correlation. P < 0.05 was considered statistically significant. Results: The study enrolled 450 Okirika participants (245 males, 205 females). Males were significantly taller, while females had higher BMI and greater central obesity. Males had larger right lobule width (17.3mm vs 16.3mm) and left ear width (31.1mm vs 30.3mm). Ear width measurements showed prominent sexual dimorphism. Sexual dimorphism was most pronounced in ear width measurements, with males having larger dimensions. External ear dimensions didn't correlate with stature in males and females. Ear size and height are independent traits, making ear measurements unreliable for predicting stature. Conclusion: This study provides valuable insights into Okrika tribe's external ear morphology, highlighting significant sexual dimorphism in auricular width dimensions. The findings offer a valuable reference for clinicians and forensic experts, guiding reconstructive surgery and sex estimation. The study contributes to external ear morphometry knowledge, emphasizing the need for population-specific research in diverse populations.

A quality by design (QbD)-based on high resolution, stability-indicating high performance liquid chromatography (HPLC) method was developed for determining the impurities in Linezolid oral suspension dosage forms. Using this method six known were impurities qualified, and two degradants were quantified with excellent peak resolution. Using pH 3.0 0.02M potassium phosphate buffer as buffer. For mobile phase-A consisted of 80% buffer, acetonitrile 10%, and 10% methanol in the ratio of 80:10:10(v/v/v), while mobile phase B consisted of methanol and buffer in the ratio of 60:40, (v/v) methanol and buffer. The column was maintained at a temperature of 30°C, with a flow rate of 1.0 mL/min. UV wavelength at 254 nm. The method exhibited high specificity and demonstrated linearity over the concentration range of 0.502–6.025 µg/mL, with a correlation coefficient (r²) greater than 0.999. Accuracy exceeded 97%. The method was validated in accordance with the guidelines established by the International Council for Harmonisation (ICH), covering parameters such as specificity, linearity, precision, accuracy, and robustness. Forced degradation studies revealed that Linezolid oral suspension was sensitive to acid and oxidative stress conditions. The developed method is considered suitable for routine quality control applications, including impurity profiling and stability-indicating analysis of Linezolid oral suspension.

Febrile convulsions are the most common paroxysmal events in childhood and are a leading cause of emergency visits, frequently provoking fear, distress, and harmful home practices among caregivers. This study assessed mothers’ knowledge, attitudes, and practices regarding home management of febrile convulsions in under‑five children at Manna Mission Hospital and identified gaps to inform targeted educational interventions. A descriptive cross‑sectional hospital‑based study was conducted among 100 mothers who’s under‑five children were admitted with a diagnosis of febrile convulsion between 1 July and 31 August 2022. Data were collected using a structured interviewer‑administered questionnaire and analyzed with SPSS version 23 using descriptive statistics. Most participants were aged 20–39 years, and 70% had heard of febrile convulsions and believed they could be managed. Overall, mothers demonstrated generally adequate knowledge and predominantly positive attitudes; 92% agreed that febrile convulsions are a serious condition and 81% rated prescribed medications as very beneficial. In addition, 60% strongly agreed that every febrile child should be taken to a hospital. However, despite this favorable knowledge and attitude profile, 70% provided medically incorrect responses regarding specific home management actions, indicating substantial gaps in practical skills and reliance on inappropriate or potentially harmful practices. These findings reveal a critical knowledge–practice disconnect and underscore the need for structured, context‑appropriate, nurse‑led educational interventions focused on safe home recognition and first‑line management of febrile convulsions. Implementing and evaluating such interventions in Hospital could reduce preventable complications and improve child health outcomes in this vulnerable population.

Detailed sedimentary facies and depositional environment studies were carried out on clastic deposits outcropping around Opi and its environswithin the Ajali and Nsukka Formation of the Anambra Basin. This defines the depositional facies, and sandstone hydrodynamics. The results revealed sixlithofacies which are systematically recognized into four genetically connected facies associations based on the textural parameters and diverse sedimentary structures derived from the hydrodynamic controls. The sedimentary facies include Structureless sandstone facies, Heterolith facies, Mudstone facies, Wave ripple facies, Parallel laminated sandstone facies and Planar Cross bedded Sandstone facies with its respective structural elements pivotal in the qualitative and quantification of the lithofacies and facies association description. The facies associations systematic paleo-environment diagnosis reveals depositional in fluvial, upper shoreface to lower shoreface depositional settings. The sandstones are predominantly medium to coarse grained and poorly sorted, indicating high-energy depositional conditions. Furthermore, their symmetrical skewness suggests the depositing medium operated at a steady velocity over a prolonged period, a characteristic feature of fluvial systems.