Background: Uncontrolled diabetes is a serious medical condition that can lead to various complications, including ulcerated boils on the legs. These complications occur due to the neurovascular complications associated with diabetes. Staphylococcus aureus and Streptococcus agalactiae are frequently encountered pathogens, and polymicrobial infections are prevalent. Antibiotic treatment targets commonly isolated organisms by considering local resistance profiles, patient preferences, and infection severity. Mild to moderate infections may be managed with oral antibiotics, whereas severe cases require intravenous therapy. Severe or persistent cases may require surgical intervention and specialized, multidisciplinary wound care. Case Presentation: In this case report, we present the case of a patient who presented with an ulcerated boil of the left leg that initially appeared as a pimple a week ago. The patient had been diagnosed with type 2 diabetes mellitus (T2DM) but had discontinued medication a year ago due to potential side effects. Conclusion: This case emphasizes the importance of maintaining proper diabetes management and adherence to medication to prevent complications, such as ulcerated boils on the legs.

This study aims to investigate the factors influencing university students’ intention and behavior toward eLearning in Kathmandu Valley, Nepal. The research framework used in this study was the Unified Theory of Acceptance and Usage of Technology (UTAUT). The most common factors associated with UTAUT are social influence, facilitating conditions, habit, performance expectancy, effort expectancy, behavioral intention, and use behavior. Data were collected from 385 university students through a closed-ended questionnaire through social media platforms. The demographic information of respondents was summarized using SPSS version 25 software, while structural equation modeling was performed using SmartPls version 3 to identify the factors that influence behavioral intention and use behavior of eLearning. The data analyses revealed that performance expectancy, effort expectancy, facilitating conditions, social influence, and habit all significantly influence the behavioral intention of eLearning, with facilitating conditions being the most significant factor. Similarly, habit, facilitating conditions, and behavioral intention also significantly influence the use behavior of eLearning, with facilitating conditions as the most significant factor. It suggests that students are more likely to utilize eLearning tools when they have access to various technical devices and receive sufficient support from educational institutions. Therefore, universities should prioritize accessibility, feedback mechanisms, and seamless integration of eLearning into curricula. Peer support, technical assistance, and promotion of the benefits of eLearning are also essential for fostering engagement. By focusing on these aspects, eLearning adoption can be optimized, leading to improved academic performance and learning outcomes among university students in Kathmandu Valley.

Diabetic nephropathy is the leading cause of end stage renal disease world wide. Approximately one third of patients with type 2 diabetes have hypomagnesemia, mainly caused by enhanced renal excretion. Magnesium deficit in the diet would induce insulin resistance in humans. If it is chronic, this may lead to macro-vascular and micro-vascular complications of diabetes. This study was designed to know the relationship of serum magnesium level in type 2 diabetic patients with microalbuminuria. This study was conducted at the Department of Laboratory Medicine in Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. In this study, serum magnesium level and urine microalbumin level of 60 type 2 diabetic patients were measured. Both serum magnesium and urine microalbumin levels were measured by biochemical auto analyzer (Siemens Dimension RL Max). The mean serum magnesium level is lower in type 2 diabetes mellitus patient. There was a negative correlation between serum magnesium level and urinary microalbumin in hypomagnesemia diabetic patients. Identifying and treating hypomagnesemia can delay end stage renal disease in diabetic patient and reduce the clinical and economic burden of diabetic complications in future. The potential benefits of supplementing magnesium in type 2 diabetic patients with hypomagnesemia need to be evaluated further.

Background: Irritable Bowel Syndrome (IBS) is a prevalent functional disorder characterized by gastrointestinal symptoms and extra-digestive manifestations without clear organic etiology. Psychiatric comorbidities, including mood and anxiety disorders, are common among individuals with IBS, impacting healthcare-seeking behavior. Objective: This study aims to assess psychiatric morbidity in individuals with IBS. Methodology: A prospective observational clinical study was conducted at the Department of Gastroenterology, tertiary hospital, from June 2021 to June 2022. Convenient sampling was used to select 100 diagnosed cases of IBS aged 18 and above. A semi-structured questionnaire was developed to collect socio-demographic data, and psychiatric morbidity was assessed using the Structured Clinical Interview for DSM-V Axis-I disorders (Clinician Version). Data were analyzed using SPSS version 20. Results: Among the participants, 60% were male and 40% were female. Most participants (80%) exhibited psychiatric disorders, with depressive disorder being the most prevalent (30%), followed by anxiety disorder (29%) and somatoform disorder (10%). Non-psychiatric disorders were diagnosed in 31% of participants. Conclusion: Depressive disorder emerged as the predominant psychiatric illness in individuals with IBS, followed by anxiety disorder and somatoform disorder. A comprehensive psychiatric evaluation is essential for effectively managing the symptoms of IBS, particularly in individuals with psychiatric comorbidities.

Granulomatous mastitis is a chronic inflammatory disease of the breast with unknown etiology mostly seen in parous women shortly after their last pregnancy. It is crucial to differentiate granulomatous mastitis from cancer and definite diagnosis is established by histopathological examination. Its treatment is variable and the most appropriate treatment protocol is yet to be identified. Aim of the study was to compare the performances of fine needle aspiration and Core biopsy of breast lump verified by histopathological examination as “Gold standard”. 227 women presenting with breast lump were included in this study. After selection, fine needle aspiration and core biopsy were done at same sitting and follow-up resection histopathology with 122 cases (53.74%) were performed in the laboratory. 40(17.62%) cases were diagnosed granulomatous mastitis by either fine needle aspiration or core biopsy, the reports of 23 cases (57.5%) were concordant in both the procedures and discrepancy was observed in reporting of 17 cases (42.5%). 36 cases (90%) were resected for histopathology and 33 (82.5%) breast lumps were diagnosed granulomatous mastitis. Diagnostic accuracy, sensitivity, specificity, negative and positive predictive values of fine needle aspiration cytology and Core biopsy were calculated. The diagnostic accuracy of core biopsy was 97.54% and that of fine needle aspiration cytology was 89.34%. Specificity, sensitivity, positive and negative predictive values of core biopsy were 97.77%, 97.29%, 94.73% and 98.87% respectively. The specificity, sensitivity, positive and negative predictive values of fine needle aspiration were 97.77%, 70.27%, 92.85% and 88.88% respectively. The accuracy of core biopsy was much higher than that of fine needle aspiration and also the performances of the combination of two procedures were superior to the individual test alone.

The study investigated Effective Implementation of Entrepreneurship Education in Public Secondary Schools in Rivers State for Productivity and National Development. Three research questions and three corresponding hypotheses guided the study. The study adopted the descriptive survey design. A sample size of 86 was drawn from a population of 258 principals of senior secondary schools in Rivers State. A validated instrument titled implement of entrepreneurship education for productivity and national development questionnaire was used for data collection. The instrument yielded a reliability index of 0.79. The mean and standard deviation were used to answer the research questions, while the z-test was used to test the hypotheses. The findings revealed that effective implementation of entrepreneurship education will enable the students to be creative, innovative and productive, which in turn will lead to productivity and national development.

Oilseed crops are third most important for human being after cereals and sugars. Sunflower is a vital oilseed crop, which is grown globally for its oil purposes. Sunflower seeds are also the most important protein source. Sunflower contains two primary protein types: water-soluble albumins and salt-soluble globulins. The genotype plays a crucial role in determining the fatty acid composition of oil. However, environmental factors like water availability and temperature fluctuations during the grain-filling stage can also significantly impact on oil content. That’s why this study was aimed to investigate the impact of water deficit environments on seed yield and related traits of sunflower hybrids. In this study seven sunflower hybrids (SF-177, Pl-64 A 93, Hysun-33, Hysun-39, US-666, FSS-64 and Agsun-5264) were sown according to RCBD by using three replications. Data was recorded days taken to initiation of flowering, plant height, 1000 seed weight, oil content and protein content. Results showed that drought stress adversely affected all the parameters in this experiment, but some hybrids perform better for yield and oil content under drought conditions. Such as hybrid SF-177 and Hysun-39 represented least difference in 1000 achenes weight under normal and drought conditions. Hybrid FSS-64 (44.33%) and Hysun-33 (43.66%) showed highest oil content under drought conditions. While hybrid Agsun-5264 and Hysun-39 showed maximum protein content under drought stress.

Since its publication in 2020, Shuggie Bain, the debut novel by Scottish author Douglas Stuart, has attracted scholarly attention for its unique ecological perspective. Utilizing the theoretical framework of eco-criticism and drawing on the tripartite division of ecology proposed by Chinese scholar Lu Shuyuan, this paper provides an in-depth interpretation of the novel Shuggie Bain in three dimensions of natural ecology, social ecology, and spiritual ecology, aiming to reveal the ecological imbalance and human alienation in Glasgow, a major industrial city in Scotland during the 1980s. This interpretation will also provide readers with a new research perspective for analyzing Shuggie Bain, enhancing their understanding of the rich ecological implications of it.

Background: Postpartum cardiomyopathy is an unusual type of heart failure during pregnancy that can result in significant maternal mortality in underdeveloped nations. The risk factors and in-hospital outcomes of this illness are still poorly known. Objective: To find out the risk factors and postpartum cardiomyopathy in hospital outcomes in a tertiary level hospital in Bangladesh. Materials and Methods: This descriptive study was conducted from January 1st 2022 to Dec 30th 2022 in the Department of Cardiology, Northeast Medical College, Sylhet, Bangladesh. PPCM was diagnosed as left ventricular ejection fraction (LVEF) ≤ 45% toward the end of pregnancy or within 05 months after delivery by standard Echocardiographic evaluation. In this study 77 cases of PPCM enrolled, excluding other causes of heart failure. Results: The mean age was found 27.0±5.83 years. Majority (45.45%) patients were diabetes mellitus followed by 26 (33.7%) hypertension, 33 (42.86%) obesity, 29 (37.66%) anemia, 16 (20.78%) pre-eclampsia and 14 (18.18%) dyslipidemia. Total 24(31.17%) were dead, 4(5.19%) were complete recovery, 12(15.58%) were partial recovery and 37(48.05%) were still suffering from heart failure. Conclusion: Diabetes, hypertension, obesity, anemia, pre-eclampsia, and dyslipidemia were all found as risk factors for postpartum cardiomyopathy in this study.

Introduction: Burn injuries remain a significant public health issue, especially in low- and middle-income countries where comprehensive data is scarce. This study provides a detailed analysis of burn injuries in Northern Bangladesh, focusing on epidemiological characteristics and factors influencing burn severity and incidents. Methods: This retrospective study analyzed 477 cases of acute, unintentional burns recorded between January 2022 and December 2022 at the Rangpur Medical College Hospital's Burn and Plastic Surgery unit. Data on demographics, burn types, etiology, and severity were collected from hospital registers. Statistical analysis, including chi-square tests and logistic regression, was used to identify predictors of burn severity. Result: Of the 477 documented cases, females represented 62.05% (296 cases) and males 37.95% (181 cases). Flame burns predominated, comprising 70% of incidents, significantly impacting females engaged in cooking activities. The data revealed a distinct seasonal trend with a significant peak in January, where 40% (191 cases) of annual burn incidents occurred due to campfire exposure. The analysis further demonstrated that burns covering more than 30% of total body surface area (TBSA) were significantly associated with higher morbidity and mortality, with third-degree burns occurring in 92.9% of females compared to 55.8% of males. Logistic regression identified age (OR = 1.28, CI [1.13-2.71]), gender (OR = 1.75, CI [1.11-1.47]), and the cause of ignition (OR = 0.56, CI [0.41-0.76]) as significant predictors of burn severity. Conclusion: The findings emphasize the need for targeted interventions to address the high incidence of burns among young to middle-aged women, particularly through safer cooking practices and awareness campaigns. Additionally, public health strategies should consider seasonal risks and promote safer heating methods during colder months. This study underlines critical areas for intervention and highlights the importance of culturally tailored public health strategies to reduce burn injuries in Northern Bangladesh.

Cervical cancer remains a significant global health challenge, particularly in less developed regions, despite advancements in prevention and treatment. The World Health Organization (WHO) has prioritized vaccination as a key strategy for cervical cancer elimination. However, limited vaccine coverage persists, especially in countries like India and China. In India, cervical cancer is a leading cause of female mortality, highlighting the urgent need for population-based interventions. Human papillomavirus (HPV) is the primary causative agent, with HPV-16 and 18 being prevalent in Indian women. Since its recommendation in 2006, the HPV vaccine has shown remarkable efficacy, with the potential to prevent over 90% of HPV-attributable cancers. Recent advancements include the development of single-dose vaccines, offering a cost-effective solution to enhance accessibility. Democratizing access to vaccines is crucial for achieving WHO's goals of cervical cancer elimination.

Background: Stroke is a significant global health concern, particularly in countries like Bangladesh experiencing a rise in non-communicable diseases. The impact of stroke disabilities is profound, affecting both patients and their caregivers. Objective: This study aims to evaluate the role of caregivers in alleviating symptoms among post-stroke disabled individuals. Method: A two-arm, single-blind, randomized controlled trial was conducted over 12 weeks (July 2022-july 2023). 51 Participants, recruited from tertiary hospital departments, met specific eligibility criteria. They were assigned to either a control, n=26 or intervention group, n=25, receiving either standard care or a caregiver-mediated rehabilitation program, respectively. Assessments were conducted at baseline and endpoint, evaluating various functional and quality-of-life measures. Results: In the study, 30 out of 51 participants were male, constituting 58% of the sample, while the remaining 41% were female. Among the cohort, 24 individuals, making up 47% of the total sample, experienced right hemiplegia. Furthermore, a significant portion of the participants, 38 out of 51 individuals, accounting for 75%, resided in households featuring mobility obstacles such as raised doorsteps between rooms. Additionally, it was observed that 71% of the caregivers were spouses of the patients. In the intervention group, significant enhancements were observed in various domains of the Stroke Impact Scale (SIS), including strength, mobility, composite physical function, and general recovery, with p-values indicating statistical significance (< 0.001). Marginal improvements were also noted in the domains of activities of daily living (ADL)/instrumental activities of daily living (IADL), hand function, communication, and social participation, albeit with slightly higher p-values (0.022 to 0.030). Conversely, the control group did not exhibit significant within-group effects across these domains. When comparing caregiver burden scores between the control and intervention groups, although there were no statistically significant differences observed in the Total Burden, General Strain, and Disappointment domains, the Intervention Group displayed slight improvements in Isolation, Emotional, and Environment domains compared to the Control Group, despite these differences not reaching statistical significance. These findings indicate the multifaceted impact of the caregiver-mediated, home-based intervention on both post-stroke patients' functional outcomes and caregiver burden. Conclusion: Caregivers are essential in post-stroke care, and supporting them is vital for holistic patient support. The 12-week caregiver-mediated rehabilitation program demonstrated effectiveness in improving physical functional recovery, underscoring its practical value for chronic stroke patients.

Although present since historic times, cell blocks have still been on a back seat when it comes to diagnostics, despite having immense potential. Cell block preparations made from sedimented cells can be a useful adjunct to routine cytological methods. We, thus, present a case of a 76-year-old female who would have not been treated on time, if a cell block hadn’t been attempted.

Phalsa (Grewia asiatica L.), a member of the Tiliaceae family, is a remarkable fruit-bearing shrub with significant medicinal and nutritional value. Originating in South Asia, it has gained popularity worldwide, particularly in subtropical and tropical regions. This review comprehensively examines the botanical characteristics, medicinal properties, nutritional composition, cultivation practices, and challenges faced by Phalsa growers, with a focus on its potential for crop improvement through mutagenesis and polyploidization techniques. With around 150 species, Grewia is the sole genus in the Tiliaceae family that produces edible fruit. Phalsa bushes, known for their rapid growth, yield orbicular fruits with moderately acidic yet nutritious pulp. The fruit is esteemed for its medicinal benefits, ranging from anti-inflammatory and anti-diabetic properties to its use in treating various respiratory and cardiovascular ailments. Despite its nutritional and medicinal significance, Phalsa cultivation faces challenges such as poor post-harvest management, limited germplasm diversity, and abiotic stress susceptibility. To address these challenges and enhance Phalsa's agricultural potential, mutagenesis and polyploidization techniques have been explored. Induced mutagenesis offers a promising avenue for creating genetic diversity and improving traits such as stress tolerance and disease resistance. However, culture contamination remains a significant obstacle in achieving optimal shoot initiation and propagation efficiency. Overall, this review underscores the importance of Phalsa as a valuable crop with immense medicinal and nutritional benefits. By leveraging mutagenesis, polyploidization, and tissue culture techniques, Phalsa growers can overcome existing challenges and unlock its full agricultural potential, contributing to food security and public health.

Syzygium cumini L., known commonly as jamun, is a fruit tree with significant adaptability to diverse environmental conditions, particularly saline soils. This review comprehensively explores the adaptation mechanisms of jamun to saline environments and its agricultural significance on a global scale. Given the increasing soil salinization worldwide, understanding the resilience of crops like jamun is crucial for sustainable agricultural practices in salt-affected regions. Jamun is native to the Indian subcontinent but has been cultivated in tropical and subtropical regions worldwide. Its ability to withstand various abiotic stresses, especially soil salinity, makes it an ideal candidate for cultivation in areas prone to such conditions. This review highlights the physiological and biochemical responses of jamun to high salinity, including ion regulation, osmotic adjustment, and antioxidant activity. These mechanisms help the plant maintain growth and productivity in environments where many other crops fail. Additionally, the review discusses the importance of jamun in traditional medicine and its nutritional benefits, emphasizing its potential for enhancing food security in saline-affected areas. The fruit's rich composition of vitamins, antioxidants, and minerals underscores its nutritional value, making it a beneficial addition to the diet in regions with limited crop diversity due to salinity. Furthermore, the paper addresses the agricultural practices conducive to maximizing jamun's yield in saline environments, including suitable propagation techniques and water management strategies. It also explores the genetic diversity within Syzygium cumini species, which could be leveraged to breed varieties with enhanced salt tolerance and better fruit quality. In conclusion, the global cultivation of jamun not only contributes to biodiversity but also offers a viable solution for agricultural productivity in salt-impacted soils. Continued research and development efforts are essential to optimize cultivation practices and expand the use of jamun in saline agriculture.