Though national surveys and cross-country data in India are unavailable, there are indirect indications from several smaller reports that Nonmelanoma skin cancer may be on the rise in India. The aim of this study was to analyze the Quality of Life of skin cancer patients. Retrospective cohort of patients operated for non-melanoma skin cancer in last 1 year and paid postoperative 4-month visit formed the study population. Inclusion criteria consisted of subjects operated for non-melanoma skin cancer and paid follow up visits having sufficient physical and mental capacity. 26 subjects fulfilled the selection criteria laid down thus included in this study. Study tools were records of patients, which were obtained from Medical Records Section. If any more information was required, study subjects were contacted. Out of total 26 study subjects, Basal cell carcinomas were found in 96.15% (n=25); squamous cell carcinoma was detected in 3.85% (n=1). Single location wise more lesions were located on the nose 12.77% (n=6) and forehead 8.51% (n=4). For most patients (69.23%), the lesion had not been previously treated. 57.69% subjects did not had any other associated co-morbid condition. Paired sample t-tests revealed a significant effect on DLQI item 1 (p=0.007), item 2 (p=0.042), and item 4 (p=0.002), with scores decreasing (improving QOL) after treatment. The change in total DLQI score demonstrated a trend toward significance, with overall QOL improving after treatment (p=0.038). Formerly commonly used dermatological Quality of life tools revealed minimal handicap at initial diagnosis and slight change after treatment of nonmelanoma skin cancer. Although the associations were uncertain, improvement in some aspects of well-being after treatment of nonmelanoma skin cancer was demonstrated

The Effect of Carbamazepine on EEG tracings of some people with Seizure Disorders was studied on human subjects. This study conducted within 12-24 weeks was a prospective descriptive study involving 30 people with age range of 18-81years coming to University of Calabar Teaching Hospital (UCTH) on account of seizure disorders. The electrical activity of the brain was scanned with the placement of EEG Electro cap (with electrodes connected to the EEG equipment) on each person’s head while in sitting position and subjects were asked (at regular intervals) to close/open their eyes, hyperventilate and under photic stimulation. The results obtained from the voltage/amplitude showed no significant difference in the varying states of eye open and photic stimulation (734.23 ± 0.034) in all the regions of the head at p≤ 0.05. The background frequency showed a significant difference after carbamazepine treatment regimen (479.88 ± 0.86) in all regions of the head at p≤ 0.01 different from before treatment. From the total analysis obtained, carbamazepine decreases the voltage/amplitude, increases the background activity and reduces epileptiform activity observed during recording. From the results on voltage/amplitude of scalp EEG tracings of people, the treatment with the anti-epileptic drug has a dampening effect and suppresses the abnormal electrical impulse of the nerve cells in the human brain, thereby improving the transmission of electrical signals inside the brain. These results showed that carbamazepine reduces epileptiform activity which are indicated by spikes, sharp waves, electrographic seizures, and some other stereotyped phenomena which are strongly associated with seizures

A few studies concluded that EASI with oxytocin is a better method of induction than prostaglandin E2 gel whereas a few others observed that EASI efficiency similar to that of prostaglandin compounds. We planned a comparative study of oxytocin and prostaglandin E2 gel in induction of labour in high risk pregnant women from Tamil Nadu from a tertiary care health centre. This study was a prospective study carried out for high risk pregnant women admitted for a medically indicated induction of labor at Rajah Muthiah Medical College and Hospital, Annamalai University. A total of 100 cases were randomly distributed in two groups- 50 cases on cerviprime gel (study group) and 50 cases on oxytocin (control group). Changes in the Bishop scores, labor progress, various labor end points and outcomes of labor were assessed. In Cerviprime (Study group), improved Bishops Score was observed in 2 (4%) study subjects in whom initial Bishops Score was 0 whereas in Oxytocin (Control group), improved Bishops Score was observed in 1 (2%) study subject in whom initial Bishops Score was 0. Cesarean delivery was the outcome of intervention in 8 (16%) study subjects in Cerviprime (Study group) and 20 (40%) participants in Oxytocin (Control group). In both the groups i.e. Cerviprime (Study group) and Oxytocin (Control group), Hyper stimulation and Uterine Inertia were commonly noted Intra-partum complication whereas PPH was most common post-partum complication. Cerviprime can be used as a good tool for induction of labour and as a cervical ripening agent because of its safety to the mother and the foetus. Maternal outcome variables, i.e., induction-labour interval and induction-delivery interval are less in cerviprime as compared to Oxytocin.

The author’s earlier publications have shown the presence of nanoparticles (NPs) of the original drug material in all the higher dilutions of homeopathic drugs; viz, Lycopodium and Ferrummetallicum. The present study is to compare the two different scales of potencies discovered by Samuel Hahnemann; with the help of HRTEM and EDS. It is found that:- i) all the high dilutions (HDs) of Natrummuriaticum (Nat mur) contain NPs; ii) the size of NPs is within quantum dots (QD) size range, except for 6C, where larger particles are found (14nm); iii) NPs contain Sodium (Na) and Chlorine (Cl)in various weight percentages; iv) The smallest NPs in higher concentration are present in 50 millesimal (LM) scale; v) The weight percentage of Na and Cl is very high (more than 99%) in all the potencies of LM scale except in LM6.The combined weight percentage of Na and Cl is less than 1% in all centesimal scale of potencies except in CM, where it is 1.09%; vi) The presence of elements other than Na and Cl is many in centesimal scale. The presence of other elements has been negligible in LM scale and vii) The comparative analysis shows that LM scale HDs are rich in the NPs than in centesimal scale HDs.

Percutaneous tracheostomy (PCT) has rapidly emerged in recent years; it is proven to be safe and less time-consuming when compared to surgical technique. In critical care settings, the use of PCT has been widely accepted and some authors consider it the gold standard method. Although PCT is relatively a safe procedure, it still can be associated with some serious complications. Massive percutaneous emphysema is a rare complication of PCT, which might be life-threatening. We report a patient with Guillian-Barre syndrome (GBS), who was admitted to an intensive care unit and required prolonged ventilation. Bedside PCT was performed and ended with the development of an immediate diffuse massive surgical emphysema and desaturation, followed by cardiac arrest regardless of the treatment measures

Search and creation new biologically active compounds which exhibit diuretic action is an current task of the modern Medical Chemistry. In order to identify diuretic activity a series of 5-substituted of 1,3,4-thiadiazole have been investigated. As index of urinary intensity the amount of urine was considered allocated by animals for 2 hours in terms of 100 g of body weight. In determining the diuretic action, a hydrochlorothiazide was selected as a comparative preparation. Screening research which have been conducted together with the study of the effect on the excretory renal function showed that the synthesized compounds exhibit diuretic activity, competing with the comparison standard. The comparative analysis of the biological action of 5-substituted of 1,3,4-thiadiazole and the preparation "Hydrochlorothiazide" showed that the most active among these compounds are derivatives with code 1.1 and 2.2, which significantly exceed the diuretic effect of the reference medicine. The prospectivity and feasibility of further targeted synthesis of this class of substances has shown to create more effective and safe medicines with diuretic action