Abstract: Preconception care is any intervention provided to women and couples of childbearing age, regardless of pregnancy status or desire, before pregnancy, to improve health outcomes for women, newborns and children. Preconception care mainly focuses on health promotion, screening and interventions for women of reproductive age to reduce risk factors that might affect future pregnancies. A descriptive research design was used for this study. Non- probability purposive sampling technique was used to select the respondents. Two hundred twenty-seven reproductive age women were interviewed face to face using structured questionnaires. Most of the respondents 99 (43.61%) were in between the age group of 21-25 years. Majority of respondents 218(96.03%) belonged to Hindu religion. Most of the respondents 152(66.96%) belonged to nuclear family. Only 65(28.63%) had information regarding preconception care. Majority of respondents 192(84.58%) had average level of knowledge. Highest knowledge score was in the area of reproductive health risk factors, and lowest in the area of health promotion. The overall mean percentage was 57.39. There was significant association of Reproductive age women had average level of knowledge on preconception care. Highest knowledge was in the area of reproductive health risk factors where lowest was in the area of health promotion. Awareness program is required to improve the different aspects of knowledge regarding preconception care.

Abstract: Statins are the treatment of choice for controlling hypercholesterolemia in patients with cardiovascular risk. Although all statins are HMG-CoA reductase inhibitors, they possess different chemical structure, pharmacokinetic profile and lipid modifying efficacy. From the published literature, it is known that Rosuvastatin calcium is more effective in lowering bad cholesterol and raising good cholesterol compared to rest of statins. Extensive analytical methods for the determination of Rosuvastatin are more complex, expensive and time-consuming. So the present study is focused on development and validation of a reliable, simple and economic method for the estimation of Rosuvastatin Calcium in bulk and formulation. Analytical method development being a vital part of pre-formulation and formulation, research and development obviates the need to develop reliable and economical methods for the estimation of drugs in bulk and formulation. UV Spectroscopy is one of the earliest and widely used methods in drug analysis despite the availability of chromatographic and hyphenated techniques. A simple, precise, sensitive, accurate and economical method has been developed for the estimation of Rosuvastatin Calcium in bulk and formulation. The drug exhibits an absorption maximum at a wavelength of 240nm with 0.1N sodium hydroxide as solvent. Beer’s law is obeyed in the concentration range of 1-6µg/ml and percentage purity is found to be 98.90%. LOD and LOQ values are found to be 0.603 and 0.830µg/ml. The developed method is validated statistically as per ICH guidelines and the results obtained are within acceptance criteria related to linearity, accuracy and precision.

Abstract: We present the case of 30 year old male patient of Apert Syndrome with cryptorchidism and recurrent life threatening hemoptysis. Subsequent investigations revealed bronchiectasis. We would like to highlight the fact that complications secondary to congenital anomalies, if not addressed early, lead to medical, financial and social burdens that are otherwise avoidable.

Abstract: We present the case of 30 year old male patient of Apert Syndrome with cryptorchidism and recurrent life threatening hemoptysis. Subsequent investigations revealed bronchiectasis. We would like to highlight the fact that complications secondary to congenital anomalies, if not addressed early, lead to medical, financial and social burdens that are otherwise avoidable.

Abstract: Opsoclonus-myoclonus syndrome is a rare neurological disorder, usually found in children and associated with neuroblastoma. In adults it is rare and associated with malignancies, toxic medications, metabolic disorders, brain anoxia or autoimmune causes. Here we present a case of post infectious opsoclonus-myoclonus-ataxia syndrome who recovered completely after immunotherapy.

Abstract: Polycythemia Vera a myeloproliferative disorder sometimes associated with vascular complications like stroke. The clinical course may be complicated by deep vein thrombosis at multiple sites if the underlying hematological disorder is not corrected. We present 3 cases of cerebrovascular disease complicated by polycythemia and the problems that came up during their management. All three cases could be managed successfully and are on follow up as outpatients.