Abstract: A novel stability indicating RP-HPLC method having a very short run time was developed and validated for determination of assay of Voriconazole in bulk solution, lyophilized injectable dosage form and in physiological compatible solutions. The method is novel, rapid, precise, accurate and capable of separating known impurities and degradants from Voriconazole peak proving the stability-indicating nature of the method. The analytical method consists of isocratic elution at a flow rate of 0.8 mL/min on a Devolosil C18 column (100 x 4.6 mm, 3μm) at temperature of 45°C and UV detection wavelength of 254 nm. 10µL of the voriconazole sample was injected and peak was eluted at about 2.5 min. with total run time of 10 minutes. The % recovery was well within the range between 98% and 102%. The RSD for precision and accuracy of the method was found to be less than 2%. The method was validated as per the International Conference on Harmonization (ICH) guidelines and can be successfully applied for routine analysis of Voriconazole in bulk samples and its formulations.

Abstract: Metal clusters at zero oxidation sate are found to have very good applications in medical and bio-medical field of research including drug designing. Very recently organometallic carbonyl clusters of group 8 elements are tested as very good contrast agent for photoacoustic spectroscopy based live cell imaging. Quantum computation based investigation is initiated by Bag and Ghorai to improve contrast behavior of this class of compounds. In this article I have presented the efficiency of glucose modified bicyclophosphite derivative of tri-ruthenium carbonyl clusters as photoacoustic contrast agent. I have studied the effect of number of substitutions. In my calculation solvent effect is also included.

Abstract: The purpose of this study was to investigate the chemical composition of the essential oil from salvia officinalis collected from north east of Algeria. The oil was isolated by hydrodistillation in a Clevenger-type apparatus and analyzed by GC/MS. The yield of the essential oil was 1.48% (v/w) and thirty seven constituents were identified according to their chromatographic retention times and mass spectra, corresponding to 100% of the compounds present. The major constituents of the oil were caryophyllene (25.87%), 1-alpha- Terpineol (16.85%), (+)-Ledene (10.05%) and Allo-aromadendrene (6.99%). The essential oil studied was not similar to those found in the literature; however, the main compounds of this oil present several interesting biological activities.