Objectives: The purpose of this systematic review is to investigate the risk factors and association of the incidence of diabetic kidney disease in adolescents with type 1 diabetes (T1D) patients. Methods: We conducted a thorough search of PubMed, SCOPUS, Web of Science, Google Scholar, and Science Direct to find pertinent literature. Rayyan QRCI was utilized during the entire process. Results: We included eight studies with a total of 11,468 T2D patients and 4966 (43.3%) were females. The available literature on the association between T1D and CKD among adolescents lacks epidemiological data on the prevalence and sex differences. Higher eGFR, diabetes duration, low C-peptide levels, glycemic control, age at a clinic visit, advanced glycation end products, and BMI were reported as significant risk factors for developing renal impairment in adolescents with T1D. Conclusion: The results of this research point to the necessity of a standardized screening procedure for the early identification and appropriate treatment of DKD. In order to provide an accurate assessment of this illness, methodological approaches should be taken into account. Furthermore, it's imperative to educate teenagers with T1D about the possibility of DKD, which can result in renal failure and even death. Future improvements in the quality of life for teenagers with T1D are anticipated as a result of this awareness.

Objectives: To investigate the prevalence and mechanisms of atrial fibrillation (AF) among type 2 diabetes (T2D) patients. Methods: We conducted a thorough search of PubMed, SCOPUS, Web of Science, Google Scholar, and Science Direct to find pertinent literature. Rayyan QRCI was utilized during the entire process. Results: We included twelve studies with a total of 587,822 T2D patients and 299,957 (51%) were females. The prevalence of AF among T2D patients ranged from 0.2% to 41.63% with a total prevalence of 44936 (7.6%). The reported risk factors for developing AF among T2D patients were impaired glucose tolerance (IGT), men, obesity, elderly patients, those with lower socioeconomic backgrounds, those who currently smoked, people with reduced renal function, long-term BP fluctuation, and microvascular illness. Conclusion: Although the exact relationship between T2D and AF is still unclear, there is a significant correlation. Certain glycemic control studies indicate that therapeutic HbA1c levels in conjunction with well-controlled T2D do not significantly reduce the risk of new-onset AF in T2D patients. Further investigation is needed to fully comprehend the connection between T2D and AF. In the interim, healthcare professionals can treat people with T2D, AF, or possibly both illnesses at the same time according to accepted guidelines.

Background: Gallbladder diverticula have the appearance of hernia-like protrusions of the gallbladder wall. This disorder may not be diagnosed until surgically resected because it has no clinical significance unless there are associated diseases. Gallbladder pseudodiverticula have an acquired cause, multiple fundal lesions, an association with gallstones, internal saccular lesions without external hernia-like protrusions, and little to no smooth muscle in the gallbladder wall. Case Presentation: A 15-year-old boy in Saudi Arabia presented with right hypochondrial pain and dyspepsia. Imaging revealed innumerable gallstones in a distended gallbladder, indicative of chronic calculous cholecystitis. Elevated liver enzymes and coagulation abnormalities initially postponed surgery, but subsequent improvement allowed for laparoscopic cholecystectomy. Histopathological examination confirmed chronic calcular cholecystitis without malignancy. Conclusion: This case underscores the importance of recognizing and managing chronic calculous cholecystitis in adolescents promptly especially if associated with complication as pseudodiverticula. Successful treatment with laparoscopic cholecystectomy resulted in a positive outcome for the patient. Further research and case studies in this age group can enhance our understanding of the disease and optimize management strategies.

Chronic hepatopathies are cosmopolitan disorders, the most common of which are chronic hepatitis and cirrhosis. Cirrhosis is a pathology of diverse etiologies characterized by diffuse disorganization of the normal hepatic structure due to hepatocyte destruction, with the appearance of regenerative nodules surrounded by fibrosis compressing the hepatic vascularization and causing portal hypertension. We report the case of a patient hospitalized in intensive care for decompensation of chronic hepathopathy during her 4th pregnancy, and we will describe the various consequences of pregnancy on this type of hepathopathy and vice versa via a detailed review of the literature.

Introduction: Blood donation is a remarkably safe medical procedure; however, it is affected by attitudes, beliefs, and knowledge level. Nevertheless, blood is a veritable tool in many life-saving situations. Despite the increased demand for blood, the supply of safe blood has been inadequate. Although blood is the essence of life, and is one of the most precious donations; blood transfusion services are facing shortage of blood all over the world. A significant percentage of people have false beliefs about blood donation. Increase in the level of knowledge and correction of false beliefs should be the top most priority. Therefore, studying factors contributing to their knowledge, attitude and practice of blood donation is essential. There are studies that investigated the effectiveness of interventions or procedure changes in blood donation settings on outcomes including donor deferral, disclosure of risk factors, and rates of errors and omissions. Researchers also identified several interventions to improve donor compliance that have been tested in blood donation settings and provided evidence for the effectiveness of computerized interviews in improving detection of risk factors. Interventions can utilize the processes of change (POC) measure to guide stage matched interventions to encourage use of relevant experiential and behavioral strategies to increase blood donation. Interventions to recruit and retain blood donors in the general population have been classified into six approaches: motivation, reminders and commitments, altruism, measurement of cognitions, incentives, cognition based. Effective recruitment and retention are two different processes and may require different approaches. For example, retention may be influenced more by interventions that focus on actions during or after donation rather than interventions prior to the blood donation appointment. Educational intervention was effective in improving the knowledge and attitude towards voluntary blood donation among medical students. Continuous enlightenment will influence potential blood donors to have better knowledge and positive attitude toward voluntary blood donation.

Diabetes mellitus (DM) is a global health issue due to its prevalence and catastrophic health effects. Synthetic hypoglycemic agents can treat diabetes, but they have side effects. Therefore, natural remedies for diabetes are now gaining popularity. Marine benthic algae are rich in phytochemicals and other bioactive compounds. Inhibition of carbohydrate hydrolyzing enzymes in-vitro and lower blood glucose levels in-vivo during fasting and postprandial testing imply seaweed extracts and their bioactive ingredients may treat diabetes. This study investigated the phytochemical properties of Asparagopsis taxiformis from the southern part of St. Martin Island in Bangladesh and examined the anti-diabetic activity of its 50% ethanolic extracts in-vitro and in-vivo. After establishing traditional phytochemical presence, total phenolic and flavonoid content was estimated, and an in-vitro alpha-amylase inhibitory activity test was performed. In-vitro anti-diabetic investigation shows that 50% ethanolic extract of Asparagopsis taxiformis reduces diabetes less than acarbose. In-vivo anti-diabetic tests also showed similar results compared to the control group when their blood glucose level was measured. After 14 days of treatment with the 50% ethanolic extract of Asparagopsis taxiformis, the treated group of mice didn’t show any considerable lowering activity when their body weight, lipid profile, kidney function, and liver function (SGPT, SGOT) were compared to the control group. Though Asparagopsis taxiformis has manifold benefits, 50% ethanolic extract of this alga didn’t show any antidiabetic properties suggesting more studies in different solvents are required to evaluate the antidiabetic properties.

Introduction: Spinal epidermoid accounts for < 1% of all primary cord tumor. This rare benign lesion may be congenital or acquired. Invagination of epidermal elements into the neural tube during embryonic period leads to the development of epidermoid cyst. Case Presentation: A 2 year old girl presented with a spontaneous intergluteal swelling with dermal sinus and lower limbs weakness. The lumber MR demonstrated an intradural lesion from L3 to L5 levels that compressed cauda equine or nerve roots. MR findings were compatible with an epidermoid cyst with dermal sinus without any coexistent spinal dysraphism. The patient underwent microsurgical laminectomy from L3 to L5, tumor was resected and sent for histopathological examination. A pearly white tumor was found and histopathology revealed an epidermoid tumor. Post-operative Magnetic Resonance Imaging (MRI) finding was total removal. Conclusion: Diagnosis of spinal epidermoid cyst is often delayed due to its obscure presentation. Here, we presented spinal lumber intradural epidermoid cyst with dermal sinus which was treated successfully with microsurgical total resection with preservation of spinal stability and neurological function. Post-operative follow up with MRI is helpful.

Background: Lower back pain (LBP) is the most frequent medical condition requiring rehabilitation in most countries, and it is also the most common medical issue among individuals with disabilities. Numerous illnesses, such as nephrolithiasis, endometriosis, tumors, fibromyalgia, and psychological disorders, can induce back pain that is not related to the spine. Objective: To determine the disability prevalence among patients with chronic non-specific low back pain Materials and Methods: The cross sectional observational study was conducted in the Department of Physical Medicine and Rehabilitation, Dhaka Medical College & Hospital, Dhaka. Total 103 cases diagnosed individuals with chronic non-specific low back pain after fulfilling enrollment criteria was enrolled in this study. Question about sex life (ODI-8) was asked at the end of the interview. Disability refers to impairment, activity limitation and participation restrictions that may occur with a health condition. Low back pain was defined as pain and discomfort, localized below the costal margin and above the inferior gluteal folds with or without referred leg pain. Statistical analyses were carried out by using the Statistical Package for Social Sciences version 23.0 for Windows (SPSS Inc., Chicago, Illinois, USA). Results: Prevalence of the disability more than half (52.4%) of the patients had severe disability, 27(26.2%) had moderate, 14(13.6%) had crippled and 8(7.8%) had minimal disability. Conclusion: The prevalence of severe disability in Chronic Non-Specific Low Back Pain was 52.4%. The duration and severity of pain are significantly correlated with impairment.

Background: Generalized anxiety disorder (GAD) is a psychological illness characterized by excessive worry and physical symptoms such as sweating and fast heartbeat. Understanding the prevalence of GAD among university students is crucial for addressing mental health challenges in this population. Objective: This study aimed to determine the prevalence of generalized anxiety disorder among university students in Saudi Arabia and also to assess levels of depression and stress among them. Methods: A systematic review following PRISMA guidelines was conducted. A comprehensive search was performed in major databases using specific keywords related to anxiety, students, and Saudi Arabia. Studies conducted between 2020-2024, in English, and with free accessible articles were included. Data extraction and synthesis were carried out to analyze relevant findings. Results: The systematic search yielded 41 study papers, with 8 meeting eligibility criteria. Various studies reported high levels of anxiety, depression, and stress among university students in Saudi Arabia, with female students showing higher prevalence rates. Factors such as age, gender, and academic performance were associated with increased anxiety and depressive symptoms. Conclusion: The study revealed a high prevalence of generalized anxiety disorder, depression, and stress among university students in Saudi Arabia, emphasizing the need for interventions and support systems. Early detection and management of anxiety disorders are essential for mitigating the economic and social burden associated with these conditions, especially in the context of the COVID-19 pandemic. Addressing mental health challenges among university students is crucial for promoting overall well-being and academic success.

Expired and unused medicines are potentially toxic substances that should be managed effectively to avoid accumulation of potentially toxic pharmaceuticals in the hospital and environment. This study aimed to identify and assess the disposal practices of pharmaceutical waste at tertiary care teaching hospital. A cross-sectional prospective questionnaire study was conducted for a period of six months at tertiary care teaching hospital with a sample size of 120. Healthcare professionals above the age of 18 years were included in the study. Data from the questionnaire was analyzed using appropriate statistical tools and Chi-square test. A pre and post educational intervention study was conducted among 120 participants. The study found that 90.83% (109) participants were under the age group of 18-25 years. Among them 77.5% (93) were female and 22.5% (27) were male. Before intervention only 80.8% (97) participants were aware of different types of bags used to dispose pharmaceutical waste, whereas after educational intervention 97.5% (117) are aware of bags used to dispose pharmaceutical waste (x2=0.000<0.001). Before intervention 55.83% (67) of participants were known of drug takeback system, after intervention 99.16% (119) known of drug takeback system (x2=0.000<0.001). Majority of the study participants agreed that safe pharmaceutical disposal practice is an important concern in both pre and post study. Hence awareness and concern regarding the problem is high. It was observed that the knowledge of healthcare staff about pharmaceutical waste management was good. We found that educational programs can improve staff awareness level on pharmaceutical waste management.