Primary rectal lymphoma (PRL) is a rare form of gastrointestinal lymphoma, representing less than 0.5% of all colorectal neoplasms; Clinical symptoms are similar to those of rectal cancer. This article presents a rare case of primary rectal lymphoma discussed by a thorough review of the literature.

The word "glomerulonephritis" refers to a group of kidney illnesses marked by immune-mediated destruction to the basement membrane, mesangium, or capillary endothelium, resulting in hematuria, proteinuria, and azotemia. Acute Kidney Injury episodes in glomerular disease are typically caused by rapidly progressive glomerulonephritis (RPGN). acute glomerulonephritis is caused by immunologically mediated damage caused by numerous infectious agents such as viruses, bacteria, or protozoa, as well as non-infectious causes such as Henoch–Schonlein purpura (HSP). The most prevalent infectious cause is post-streptococcal glomerulonephritis (PSGN). The emergency physician must conduct a thorough physical examination and obtain a complete medical history, including herbal agents, sports supplements, non-steroidal anti-inflammatory drugs (NSAIDs), angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), and calcineurin inhibitors, among other medications. In addition, the patient's blood pressure, weight, hydration status, edoema, skin manifestations, pulmonary and cardiac examinations must all be correctly monitored. Because there is no particular medication for renal illness, the treatment for acute poststreptococcal glomerulonephritis (PSGN) is mostly supportive. The underlying infections must be addressed when acute glomerulonephritis (GN) is accompanied with chronic infections. The critical care unit's expertise may be required for the treatment of individuals with hypertensive encephalopathy or pulmonary edoema. A nephrologist's consultation may be necessary. Renal function, blood pressure, edoema, serum albumin, and urine protein excretion rate should all be evaluated on an outpatient basis. In this article, we will be reviewing Acute glomerulonephritis, its evaluation as well as management.

Objective: The objective of this work is to list the surgeries using the fascia lata. Background: The fascia lata finds a place in decayed tissues. The indications are getting wider and wider. Method: We used the PubMed database with the following words: fascia lata, ilio-tibial band, fascia lata and surgery, ilio-tibial band and surgery, fascia lata and reconstruction, ilio-tibial band and reconstruction. Results: Fascia lata is used in the reconstruction of anatomical defects. Specifically, it is used in: Hip to supplement abduction- Shoulder in glenohumeral instability, repair of the cap- Hand and fingers to reconstruct tendons- Eyes: for palpebral ptosis and scleritis - Base of the skull to reconstruct defects- Central nervous system: cerebral dura mater and Cerebrospinal Fluid leak- Otorhinolaryngology: thyroplasty, parotid surgery, rhinoplasty, tympanoplasty- Digestive tract- Tendons: Achilles, patellar, fibular, patellar, patellar, bicipital brachial and crural tendons - Ligaments: anterior cruciate ligament reconstruction, inguinal and retinaculum patellar - Perineum and penis reconstruction - Urology: Genital prolapse, fistulas and penile reconstruction - Abdominal incisional hernias - Breast reconstruction - Eschar - Thorax - Encology. Finally, in experimentation, the fascia lata is tested on cadavers, animals and in vitro. Conclusion: Because of the particular properties of fascia lata in reconstruction, it renders an enormous service to surgery. The development of techniques in surgery would allow its use in other indications.

This article examines the use of oral antidiabetic agents in the treatment of heart failure. Heart failure is a serious condition that is often associated with diabetes mellitus, which worsens the prognosis for patients. Oral antidiabetic agents, such as SGLT2 inhibitors and GLP-1 receptor agonists, have recently gained increasing interest due to their potential beneficial effects on cardiac function. Clinical studies have shown that these medications reduce cardiovascular morbidity and mortality, decrease hospitalizations for heart failure, and improve cardiac function in patients with heart failure, whether they are diabetic or not. The mechanisms of action of these medications include blood pressure reduction, improvement in endothelial function, modulation of cardiac energy metabolism, and reduction of oxidative stress and inflammation. While these findings are promising, further research is needed to better understand the long-term effectiveness and optimization of the use of these medications in the context of heart failure.

Aims: The World Health Organisation defines self-medication as the act of selection and use of medicine by individuals to treat self-recognized illnesses and symptoms or by health professionals to use drugs not prescribed by the treating physician. WHO has reported a prevalence of self-medication of 32.5% to 81.5% worldwide. In Cameroon a prevalence of 67,8%, and 41,9% has been reported in some studies. This study sought to assess the socio-demographic characteristics, prevalence, associated risk factors and the common medications of self-medication at the Bonassama and Cite des Palmiers Health Districts of Douala, Cameroon. Place and duration of the study: the study was conducted from December 2022 to May 2023 in two health districts in Douala, Bonassama and Cite des Palmiers. Methodology: It was a descriptive and analytic cross-sectional study. Sociodemographic, reasons for self-medication, class of medications commonly self-medicated data was collected. Descriptive statistics, univariate and multivariate analyses will be made by Chi square and Fisher’s exact test and reported as odd ratios, adjusted odd ratios and 95% confidence intervals. Statistical significance was set at p<0.05. Results: 83% of participants carried out the practice of self-medication. One of the major reasons for self-medicate was the fact that they thought that the illness was not serious with a prevalence of 46,6%, followed by cost saving (33,2%). The most common disease treated by self-medication was headache (81,5%), and the most represented class of drug were analgesics (84,7%); drugs were bought in community pharmacies (64,7%) and illicit market (44,9%). The statistically significant reasons for self-medication were cost saving, convenience, not serious illness, prior experience, long wait times in hospitals and accessibility of pharmacies. Conclusion: Self-medication is a widespread practice throughout the world, particularly in developing countries. This study has illuminated the prevalence and causes of self-medication in our environment. The prevalence of self-medication is high due to several factors and arguments, including cost saving, convenience, illness was not serious, prior experience, long wait times at hospitals, and availability of pharmacies.

Background: Idiopathic Orbital Inflammatory Syndrome (OIS) ranks as the third most prevalent orbital disease, following thyroid eye disease and orbital lymphoma. In cases of localized inflammation, various structures within the orbit can be affected. This includes the Extraocular Muscles (orbital myositis), lacrimal gland (dacryoadenitis), sclera (scleritis), uvea (uveitis), as well as the superior orbital fissure and cavernous sinus (Tolosa-Hunt syndrome). Case Presentation: In this report, we discuss the case of a 35-year-old man who went to the Emergency Department due to intense, throbbing pain in his eye orbit and half of his head on the right side. He had been experiencing this pain for two days. The pain was aggravated by eye movement and accompanied by ipsilateral redness, mild photophobia, and blurred vision. The patient had no significant medical history prior to this episode. Upon eye evaluation, findings included mild swelling of the right eyelids, painful eye movements, inferior corneal erosions, and conjunctival chemosis with superficial and deep vessel congestion. Visual acuity was reduced due to myopic refractive error. Magnetic Resonance Imaging (MRI) revealed a soft tissue lesion in the right orbital apex extending into the right cavernous sinus, suggesting an inflammatory etiology such as Tolosa-Hunt syndrome. To investigate further, the patient underwent various diagnostic tests, including laboratory investigations, chest X-rays, and serological tests. These tests revealed unremarkable findings, ruling out systemic pathology. The patient received intravenous Solumedrol (Methylprednisolone) followed by oral Prednisolone, resulting in a dramatic improvement in symptoms. Conclusion: This case highlights the importance of a comprehensive diagnostic approach in evaluating severe orbital and hemi cranial pain. Prompt initiation of corticosteroid therapy can lead to rapid symptom resolution and favorable outcomes in patients with Tolosa-Hunt syndrome.

Biomedical Waste (BMW) is defined as any waste, which is generated during the diagnosis, treatment or immunization of human beings or animals, or in research activities pertaining thereto, or in the production or testing of biological substances. The management of Bio-medical waste is still infant all across the world. Improper management of waste generated in Health Care Facilities (HCFs) causes a direct negative impact on the community, health care workers and on the environment. The waste generated in these facilities essentially consists of solids and liquid, which may be infectious / biological (10% to 15%) and non-infectious / non-biological (85% to 90%). Effective management of BMW is not only a legal necessity but also a social responsibility. It is imperative upon all the health facilities, irrespective of their size and number of patients catered, to ensure appropriate BMW management at all levels starting from its generation to its final disposal. This study provides a comprehensive overview of India’s current BMW scenario, impact on society, legal management and various other management methods.

Malaria is one of the most serious infectious diseases found in the tropics and subtropics. P. falcifarum resistance to almost all anti-malarial drugs has necessitated the search for anti-malarial compounds. The aim of this study is to investigate the antiplasmodial effects of crude leaf and stem bark extracts of T. avicennioides, a plant utilized by traditional healers in Northern Nigeria to treat malaria and other ailments. Brine shrimp lethality (cytotoxicity) assay and acute toxicity were also evaluated, which are considered a useful tool for preliminary assessment of toxicity in plant extracts. The median lethal dosage (LD50) was calculated by administering different doses of the extract (100–4000 mg/kg) intraperitoneally to three groups of three mice each for 24 hours and observing the animals for physical sign of toxicity. Three models were employed to assess the extracts antiplasmodial effectiveness in vivo against the rodent malaria parasite Plasmodium berghei: suppressive, curative, and repository. The leaf and stem bark extracts were found to show significant toxicity to brine shrimp larvae of Artemia salina in the brine shrimp lethality test with LC50 values of >1000 and 29.6 respectively. Excitation, paw licking, and death were symptoms of acute toxicity of the extracts based on physical and behavioral observations. Death was recorded at 1000 mg/Kg of the stem bark extract and the LD50 is ≤100 mg/Kg body weight while for the leaf extract it was estimated to be ≤600 mg/Kg with no death record. In vivo evaluation revealed that the extracts significantly (P <0.05) reduced parasite count in all models (suppressive, curative and prophylactic), with high average percentage inhibition of parasitaemia (54.68, 58.67 and 65.61%) seen in both T. avicennioides leaf and stem bark extracts, which was comparable to that produced by chloroquine and artesunate, respectively (64.31&93.1; 70.08&80.67; 63.40&75.20%). Both extracts had moderate antiplasmodial activity and were non-toxic to mice and brine shrimps. This finding validates the plant's traditional use in malaria treatment.

Introduction: Many new inflammatory markers are being extensively used recently for assessing the severity and prognosis of chronic conditions. Neutrophil-Lymphocyte ratio (NLR) because of its simplicity and affordability stands out. Its applicability to psychiatric disorders specifically Depression is an eye-opener. Hamilton Rating Scale for Depression (HAM-D), a clinician-based scoring system is better among other self-scoring systems where the study population is semi-illiterate. Materials and Method: Total of 80 patients over a period of 1 year presenting to psychiatric OPD with depressive symptoms were evaluated for the severity of Major Depressive Disorder (MDD) using HAM-D scale. A score of 7-17, 18-24 and >25 was categorised under mild, moderate, and severe degrees respectively. NLR was calculated and was correlated with their severity. Statistical analysis was done using PSPP software and p value of <0.05 was considered significant. Results: Out of the 80 patients 45 were females and 35 were males. The average age was 35.41 years ± 10.13 SD. 23 patients categorised under mild depression had mean NLR of 1.56 ± 0.46 SD, 40 patients with moderate depression and 17 patients with severe depression had mean NLR of 2.70 ± 1.08 SD and 4.62 ± 1.31 SD respectively. The mean value of NLR for patients of severe depression lied in the Mild-Moderate Inflammation zone (3-7). P-value was <0.05 and was considered significant. Discussion: A novel and easy biomarker like NLR can be as useful as assessing Inflammatory Cytokines like IL-6, IL-1 and TNF-α for assessing the severity of MDD. Rise of cortisol in persistent stress favours an increase in neutrophils and a reduction in lymphocytes, and thus, increased NLR. Thus, a rise of NLR with increasing severity of Depression could become a robust tool in future for predicting mortality and severity in patients suffering from MDD.

Mature teratomas, or teratoid tumors, or benign teratomas, of the nasal cavity and sinuses are exceptional the diagnosis is histopathological and shows within the lesion different types of tissue: fat, glial, muscular, cartilaginous, bone and respiratory. Teratomas are rare congenital neoplasms that originate from pluripotent cells. In this article, we report the first case of a nasal teratoma. We also discuss methods for diagnosing and treating upper respiratory teratomas, and include a brief literature review.

The desert plant C. retrospiciens (Ehrenb.) is an inhabitant of the southern region of Kingdom of Saudi Arabia (KSA). The stem of C. retrospiciens produces a gel which is often applied by local people to cure wounds. This study was aimed at determination of the antifungal effect of the exudate gel (EG) against Candida albicans (C. albicans). The antifungal activity of EG was measured using agar well diffusion method. Results showed excellent antifungal activity of the exudate gel. The spectrum of antifungal activity of EG against C. albicans was almost equivalent to that of standard amphotericin B, with statistical insignificance (p < 0.05).

Background: Rape is a common social problem having great implication on the Victim, family, Judiciary and state. However it is very difficult to prove the actual rape because it is difficult to establish whether it is a consented sex or actual rape. Objective: To assess the pattern of alleged rape case in Dhaka city. Method: 176 cases of alleged rape were studied during the period of 2019-2022 at the Tertiary hospital, Dhaka. Results: Of these, 130 cases had consented sexual intercourse. 46 victims were subjected to rape. Cases include different age groups, their occupations, living areas, time of arrival for medicolegal examination have been studied. Most of the cases were students. An alarming number of victims were subjected to gang rape. Examination and reporting of the cases with have been discussed. Conclusion: This study shows that only one fourth of the alleged rape victims are the real rape cases. The victims of other cases had consent to sexual intercourse. There were several victims below the age of consent who cannot give valid consent to sexual intercourse as per law.

Background: The safety and feasibility of utilizing SAB as the sole anesthetic technique in otherwise healthy individuals undergoing laparoscopic cholecystectomy have been increasingly recognized. SAB offers potential advantages in terms of reduced complications, improved pain control, and avoidance of general anesthesia-related risks. Objective: To assess safety and feasibility of SAB in otherwise healthy individuals undergoing laparoscopic cholecystectomy. Method: The study included a cohort of 40 patients who underwent elective laparoscopic cholecystectomy and met specific inclusion criteria. All patients received a subarachnoid block (SAB) with 3 ml of 0.5% bupivacaine and 25 micrograms of fentanyl at the L2-L3 level. The laparoscopic cholecystectomy procedure was performed using a standard 4-port technique, while maintaining a low intra-abdominal pressure of 9-10 mm Hg through CO2 pneumoperitoneum. The patients were followed up at various time points, including 30 minutes, 4 hours, the time of discharge, and on the 7th day after the operation. Any voluntary or involuntary movements or exaggerated diaphragmatic excursions during the operation were carefully monitored. The study recorded parameters such as operation time, duration of operating room occupancy, length of hospital stay, post-operative pain levels, analgesic requirements, occurrences of nausea, vomiting, headache, right shoulder pain, wound-related complications, and patient satisfaction. Results: SAB demonstrated efficacy in all 40 patients undergoing surgery. Conversion to general anesthesia was required in two cases due to persisting low oxygen saturation. Hypotension occurred in 23.7% of patients, while 10.5% experienced right shoulder pain. The average operating time was 37.3 minutes, ranging from 21 to 77 minutes. Awkward movements and exaggerated respiratory excursions were observed in 23.7% and 18.4% of cases, respectively. Only two cases required conversion to general anesthesia. The mean hospital stay duration was 29.3 hours. No major complications were reported during the study. Conclusion: These findings suggest that SAB can be successfully and effectively used for laparoscopic cholecystectomy in healthy patients, providing a safe alternative to general anesthesia.

Background: Caudal analgesia has become popular in the management of intraoperative and postoperative pain management, further with the use of adjuvants to prolong its duration each with varying results. Caudal block is the most preferred postoperative analgesia in pediatrics, despite its limited duration of action. Many additives are used to improve the effectiveness of caudal blocks, such as opioids or a2 agonists. Recently, the use of caudal dexamethasone as an analgesic after surgery has increased. Objectives: The aim of this study is to evaluate the safety and analgesic efficacy of general versus caudal block in pediatric infra umbilical surgery. Methods: This is an observational study. This study was carried out on 50 patients the find out about the population including children in the Department of Anaesthesia, Uttara Adhunik Medical College Hospital, Dhaka, Bangladesh. The duration of the period from January 2022 to December 2022. Statistical evaluation of the results used to be got via the use of a window-based computer software program devised with Statistical Packages for Social Sciences (SPSS-24). Results: The mean duration of postoperative analgesia was 3 times longer in Bupivacaine with preservative free Clonidine Group. Bupivacaine solution Group received significantly more doses of rescue analgesic than Bupivacaine with preservative free Clonidine Group (p-value of 0.004). There was no significant bradycardia, hypotension, sedation or urinary retention in either of the groups. There was no residual motor blockade at 6 hours. Incidence of vomiting was similar in both the groups. Conclusion: Dexamethasone in combination with bupivacaine reduces postoperative pain intensity and total analgesic consumption and prolongs analgesia.

Endoscopic ultrasound (EUS) is is a technique used for the exploration of the digestive system, enabling the diagnosis and classification of gastric tumors. The aim of our study was to describe the contribution of EUS and fine needle aspiration in the diagnosis and determination of the histological type of gastric tumors. Our study consists of a retrospective descriptive study involving 36 patients. The mean age was 54 ± 14.4 years, with a female-to-male sex ratio of 2. EUS revealed an ulcerated and polypoid appearance with prominent folds in half of the cases. Fine needle aspiration biopsy was performed in 80.5% of cases. The histopathological findings were predominantly gastrointestinal stromal tumors and adenocarcinomas.

The Lefort II fracture (pyramidal fracture) or high transfacial is a solution of bone continuity of the middle stage of the face whose fracture line concerns the glabella, the ethmoid massif, the two maxillary sinuses and the pterygoids causing more or less important the mobility of the middle stage of the face. Objectives: of this study were to study the frequency of Lefort II fractures at Nianankoro FOMBA Hospital in Segou; to study the target population of Lefort II fractures at the Nianankoro FOMBA hospital in Segou; evaluate the treatment option for this pathology; to study the fate of treated patients. This was a prospective study, carried out in the stomatology and maxillofacial surgery department of Nianankoro FOMBA Hospital in Ségou over a period of 3 years, i.e. 36 months from October 1, 2016 to October 1, 2019. It covered all cases of Lefort II fractures admitted to this department for their care. During our study we recorded 225 cases of maxillofacial trauma including 17 cases of Lefort II fractures or 7.55% of all traumatic injuries admitted to the service. Lefort II fractures are a social and public health problem affecting mainly young male subjects in the 20 to 29 age group most often following accidents on public roads. Their diagnosis is made by clinical examination associated with paraclinical examination (computed tomography) which makes it possible to locate the fracture foci.

Gastrointestinal stromal tumor (GIST) is a rare sarcoma, typically starts in the cells that line the gastrointestinal tract’s (GIT) wall. While certain GISTs may develop slowly over time, others might spread drastically. However, it will indicate recurrence for certain people. Patients with locally resectable gastro intestinal stromal tumours continue to be treated primarily with radical surgery, which, in more than 50% of instances, results in a long-term remission of this disease. The first targeted medication for the GISTs treatment was the tyrosine kinase inhibitor imatinib, and is now the preferred option for treating advanced gastro intestinal stromal tumours. This case highlights recurrence of GIST for two times even after laparotomy which provides an information, that the hazards associated with this type of tumour must be reduced by receiving appropriate therapy because it can recur.