ORIGINAL RESEARCH ARTICLE | Feb. 28, 2018
Application of Myristica fragrans feed in Poecilia latipinna as an effective antibacterial agent and colour enhancer
Divya MS, Dr. Sreeja J
Page no 176-179 |
10.21276/haya.2018.3.2.12
Myristica fragrans seed (Nutmeg) famed as the prominent fatty seed of
medicinal and therapeutic quality came from the Spice island of Indonesia. It is
endowed with phytochemicals, minerals and vitamins impart medicinal values. In
captive conditions the ornamental fishes with deprived nutritional feed subjected to
diseases and faded colour produces economic loss in their trade operations can be
tackled by effective administration of plant products. In this perspective, a
comparative study made in Poecilia latipinna (yellow molly)by providing
(commercial feed) CF and TD1 (Myristica fragrans) for a duration of 60 days. The in
vivo antibacterial efficacy of feed in tissues(gut & gill) of the specimen along with
water samples from aquaria revealed positive result for TD1.The colour enhancing
ability in yellow molly yielded best result higher for TD1 considered to CF. The total
bacterial load in the water, gut as well as the gill of CF fed group was 75x104
CFU/ml, 45x104 CFU/ml& 23x104 CFU/ml while for TD1 it was 14x104 CFU/ml,
9x104 CFU/ml, 7x104CFU/ml. The quantitative estimation of carotenoids estimated
was 6.32µµg/g wet weight in control and 12.12µg/g wet weight for TD1.From the
present investigation arrived at the conclusion that TD1 provided better anti-bacterial
activity than CF (commercial feed) not only prevent disease outbreak but also
produce vibrant skin colour.
ORIGINAL RESEARCH ARTICLE | Feb. 28, 2018
An Autopsy Study of Socio-Etiological Aspects in Dowry Death Cases
G. Panneer Selvam, K.Gokula Ramanan
Page no 46-48 |
10.36348/sjm.2018.v03i02.003
Violence affects lives of millions of woman worldwide, in all societies, one of the most heinous and shocking forms among them is DOWRY DEATH, is one among the various reasons for suicidal (i.e. abetted suicide) and homicidal deaths of women in India, other being marital infidelity, sexual jealousy etc. This study done at Government Mohan kumaramangalam Medical College, Salem , was conducted during the period January 2014 – December -2015. Aims and objectives were to know the magnitude, socio etiologic profile and methods used for committing suicide/homicide, and various other factors affecting the alarming rise in incidence of dowry death and also to lend valuable suggestion to concerned authorities to prevent this heinous social evil of our society. Most of the victims were aged between 20 to 24 years of age, maximum of the victims died within three years of married life, most commonly between 1 to 2 years of married life. Burns is the most common method used for dowry deaths.
ORIGINAL RESEARCH ARTICLE | Feb. 28, 2018
Endocrine Changes Associated with Ovarian Activity in Montbéliarde Cows Raised Under Semi-arid Condition in Eastern of Algeria
Nabila Kara, Mustapha Bounechada, Houssam Chebal, Khaled Maouche, El-eulmi Lounis, Aid Meratla, Badredine Bouchama, Belkacem Chawki Chaib
Page no 180-187 |
10.21276/haya.2018.3.2.13
The objective of the current study was to investigate changing profile of
reproduction hormone (Progesterone and Estradiol) BCS and parity in relation to the
resumption of ovarian cyclicity postpartum in cows of European origin under semiarid conditions of Algeria. To measure plasma progesterone (P4) and estradiol 17-β
(E2), blood samples were collected from 21 Montbéliarde dairy cows at 30, 40 and 50
d postpartum (dPP) respectively. Body condition score (BCS) was taken before and
after calving. Cows were grouped based on progesterone concentration (resumption
of ovarian cyclicity, ≥1 ng/mL) at 30, 40, and 50 dPP into a non ovarian activity
(NOA) group (n = 6) and ovarian activity (OA) group (n = 15). P4 concentration was
higher in the OA group than in the NOA group and statistically differed at 50 dPP (p
= 0.04). E2 was higher in the OA group than a NOA group at d 30 (p = 0, 01) and d
40 (p = 0, 03). Despite superiority of BCS peri and postpartum but no significant
differences were detected between the two groups. There was no significant
difference between parity and ovarian resumption groups. Two groups were formed
based on differences in onset of postpartum resumption of ovarian activity. OA (n
=15/21 or 71.42 %) showed first ovulation between 30 d and 50 d after parturition.
NOA (n = 6/21 or 28.57 %) manifested a first ovulation > 50 d in milk.
ORIGINAL RESEARCH ARTICLE | Feb. 28, 2018
Application of QbD Approach to Development and Validation of a Novel UV- Spectrophotometric Method for Quantitative Estimation of Quetiapine Fumarate in Bulk and Pharmaceutical Formulation (Tablets)
Navjeet Kaur, Inderpreet Singh, Amit Sharma, Manoj Kumar Katual, Charanjit Kaur, Rajesh Kumar
Page no 249-256 |
10.36348/sjmps.2018.v04i02.012
Stability Indicating UV-spectrophotometric analytical method validation for the estimation of Quetiapine fumarate have already been reported, but no studies reported so far include the application of Analytical Quality by Design (AQbD) concept to the development of a comprehensive analytical UV-method for the analysis of model drug (Quetiapine fumatrate). In the present work, a simple, economic and sensitive UV spectrophotometric method has been developed using AQbD approach for the quantitative estimation of Quetiapine fumarate in bulk and pharmaceutical dosage forms i.e. tablets. The estimation of drug was done at 242 nm in simulated nasal fluid (SNF) using UV-Visible double beam spectrophotometer. In the developed method, linearity over the concentration range of 4-24μg/ml of QP was observed and was found in agreement of Beer’s law. The linear regression was found to be 0.999. The results of analysis have been validated statistically and recovery studies confirmed the accuracy of the proposed method. The precision (intra-day & inter-day) of method was found within limits (RSD < 2%). The sensitivity of the method was assessed by determining limit of detection and limit of quantification. The method was found to be repeatable as well as robust. The percentage of QP in the marketed formulation (Qutipin-100) was observed to be 99.46%. It could be concluded from the results obtained in the present investigation that the method for estimation of Quetiapine fumarate in pure form and in pharmaceutical dosage form is simple, rapid, accurate, precise and economical and can be used, successfully, in the quality control of pharmaceutical formulations and other routine laboratory analysis
ORIGINAL RESEARCH ARTICLE | Feb. 28, 2018
Diversity of Genus Ganoderma in Nagaon District, Assam
Ratul Kumar Nath, T. C. Sarma
Page no 188-195 |
10.21276/haya.2018.3.2.14
Nagaon district of Assam is located in the flood plains of the river
Brahmaputra. The physiographic features of Nagaon District makes it ideal home for
the growth of different types of economic plants. But these plants are found to be
decayed by the association of some macro fungi. Among these macro fungi, different
Ganoderma species were found to be associated with the different timber yielding
plants and palm species. Ganoderma with great diversity produce large fruitification
of different size, shape and colour. During the investigation 7 seven Ganoderma
species were collected from 10 different Revenue Circles of Nagaon district. This
work revealed that there are great diversity of Ganoderma species in Nagaon district,
Assam. Some Ganoderma species have medicinal properties.
ORIGINAL RESEARCH ARTICLE | Feb. 28, 2018
Development and Validation of Stability Indicating Method for the Simultaneous Estimation of Batcaver Sulfate, Lamivudine and Dolutegravir Sodium in Pharmaceutical Dosage forms by RP-HPLC
Gorja Ashok, Sumanta Mondal
Page no 289-296 |
10.36348/sjmps.2018.v04i02.018
A simple, rapid, specific, stability indicating method was developed and validated for the simultaneous estimation of Abacavir sulfate, Lamivudine and Dolutegravir sodium in pharmaceutical dosage form using RP-HPLC. The chromatographic separation was done using BDS column of dimensions 250mm x 4.6mm, 5m particle size with mobile phase consisting of potassium dihydrogen phosphate buffer and acetonitrile in the ratio 45:55%v/v run on an isocratic mode of flow rate 1.0ml/min. The column oven temperature was maintained at 30ºC. The detection was done at a wavelength of 240nm. The developed method was validated in accordance with ICH guidelines, evaluating accuracy, precision, ruggedness, robustness, LOD, LOQ, stability parameters and found to be within the limits. The method obeys Beer’s law in the concentration range of 150mg/ml – 900mg/ml for Abacavir, 75mg/ml – 450mg/ml for Lamivudine and 12.5mg/ml – 75mg/ml for Dolutegravir with correlation coefficients of 0.9999, 0.9996 and 0.9999 for the three drugs respectively. Forced degradation studies were conducted by exposing the standard drug solution to the various stressed conditions such as acidic, basic, oxidative, thermal, neutral and photolytic conditions. The net degradation for the drugs was found to be within the limits
ORIGINAL RESEARCH ARTICLE | Feb. 28, 2018
Deal or no Deal: Reflections on the Paris Agreement on Climate Change
Dr. Shadi A. Alshdaifat
Page no 196-208 |
10.21276/haya.2018.3.2.15
In December of 2015, the 21st Conference of the Parties to the United
Nations Framework Convention on Climate Change (UNFCC COP21) took place in
Paris. UNFCC is an international environmental agreement on climate change, of
which there are 195 States Parties. The U.N. Intergovernmental Panel on Climate
Change (IPCC) has warned of the consequences of failing to limit global temperature
rises to at least 2 degrees Celsius (above pre-industrial times), highlighting that the
impacts would pose a threat to humanity and could lead to irreversible climate
change. The meeting in Paris was hailed as a make-or-break opportunity to secure an
international agreement on approaches to tacking climate change, a commitment to a
longer-term goal of near zero net emissions in the second half of the 21st century, and
supporting a transition to a clean economy and low carbon society. This paper
discusses the issues and solutions of climate change, development and critical views,
the UAE environmental regulation, company's environmental responsibility, and the
future of the Paris Convention on Climate Change.
ORIGINAL RESEARCH ARTICLE | Feb. 28, 2018
Formulation and Evaluation of Gastroretentive Floating Matrix Tablets of Metronidazole using a Novel Non-effervescent Technique
Airemwen CO, Uhumwangho MU
Page no 257-264 |
10.36348/sjmps.2018.v04i02.013
The aim of this study was to formulate a novel non-effervescent gastro-floating drug delivery system of metronidazole using non-effervescent (sublimation and sintering) technique. Granules were prepared by wet granulation technique using varying concentration of Grewia mollis gum; 2,4,6,8% w/w admixed with 1%w/w acrylate methacrylate copolymer (Eudragit® RL100) and extra 2%w/w batch without the addition of Eudragit® RL100. Ammonium bicarbonate (30%w/w) was used as the sublimating agent. The granules were characterized for micromeritic properties. Thereafter, the granules were compressed at 30 units on the arbitrary scale load of a single punch tableting machine and the physicotechnical properties were determined. The metronidazole tablet was then sintered at 70oC for 12 h. Drug-excipient compatibility study was done using Fourier Transform Infra-red Spectroscopy (FTIR). All granules were free flowing and compressible. The metronidazole tablets had no floating lag time showing that tablets floated instantaneously. The in vitro buoyancy test of metronidazole tablet formulated using varying concentrations of Grewia mollis gum and Eudragit® RL100 was > 12 hr. The % maximum release (m∞) and time to achieve it i.e. (t∞) for metronidazole tablets were ≥88% and≥10 h respectively. FTIR studies showed that the excipients and the Active Pharmaceutical Ingredient (API) i.e. metronidazole were compatible. Grewia mollis gum has been investigated in the formulation of gastroretentive floating matrix tablet of metronidazole using sublimation and sintering technique (Non-effervescent method) which may find useful application in sustained release drug delivery particularly for drugs with short biological half-life that require frequent administration.
ORIGINAL RESEARCH ARTICLE | Feb. 28, 2018
Effects of Watering Regimes on Germination and Early Seedling Growth of Tetrapleura tetraptera (Schum and Thonn) Taub
Comfort Ajeigbe Dada, Joshua Kayode, Sunday Arowosegbe
Page no 9-13 |
10.21276/sjbr.2018.3.1.2
This study examined the watering regime that will enhance best
germination and early seedling growth of Tetrapleura tetraptera. Seeds and
seedlings of the plant were subjected to five different watering regimes viz:
watering once weekly with 50ml, watering twice weekly with 50ml, watering once
weekly with 100ml, watering twice weekly with 100ml and watering with 100ml
only on the day of planting (as control for the seeds experiment), no watering (as
control for the seedling experiments). The results of the experiment showed that
watering once weekly with 100ml was the most effective watering regime for
enhancing seed germination. This resulted in 85% germination, followed by the
seeds watered twice weekly with 50ml (65%) and watering twice weekly with
100ml (50%). Other watering regimes were less or not effective. While watering
twice weekly with 100ml was the most effective watering regime for enhancing
seedling growth in this plant. This resulted in significantly highest plant height,
number of leaves and broadest leaf area (22.00 cm, 15.00 and 27.51cm2
respectively) at the third month of planting. It also resulted in highest seedling stem
girth (3.50 cm) though this was not significantly different from seedling treated with
other watering regimes except for seedling treated with no watering which gave 0.20
cm. The results of these studies demonstrated that water supply may be a limitation
for raising Tetrapleura tetraptera in the nursery as the soil moisture influenced
germinability and early growth of this plant.
REVIEW ARTICLE | Feb. 28, 2018
Enforcement, Infringement and Protection of Intellectual Property Rights in India
Suvrashis Sarkar
Page no 197-204 |
10.21276/sjbms.2018.3.2.13
India has a strong judicial framework to safeguard people‟s rights, however
it is still has a lot of problems of infringement and enforcement of Intellectual Property
Rights (IPR). IPR exists in every innovation, but if it gets infringed, can result into
infinite business loss for the original creator considering the loss of revenue and
human intellect. Hence, it is important for businesses to know and understand the
value of IPR, manage them appropriately, protect them adequately to safeguard their
investments and efforts and reap the deserved benefits for their own work. Though
concern has always been expressed about losses and unfair practices, the recent years
have witnessed the lax in protection of IPR. It is advised that by adopting right policies
and strategies, IPR can be effectively protected with the help of law enforcement. Be it
an individual organization, an industry or even as a nation, IPR as a strategic
marketing tool has the potential to create the future where brand, technology, service,
people everything can together and become a force for development and market
leadership. The scope of IPR is expanding very fast and attempts are being made by
original creators to seek protection for their intellectual work. It is also important to
understand the enforcement measures available for protecting one‟s business or
individual creations. This paper discusses the mode of acquisition, nature of rights,
commercial exploitation, enforcement of those rights and protection available against
infringement of IPR in India with relevant suggestions for organizations to implement
and practice.
ORIGINAL RESEARCH ARTICLE | Feb. 28, 2018
Phenotypic, Allelic and Genotypic Frequencies of ABO and Rhesus Blood Groups, Secretor Status, Phenylthiocarbamide Taste Perception and Haemoglobin Variants in Ore Community, Southwestern Nigeria
C. Igbeneghu, S. A. Adedokun, A. A. Akindele, M. J. Olisekodiaka, O. Ojurongbe
Page no 14-22 |
10.21276/sjbr.2018.3.1.3
There is dearth of information on the gene frequencies of ABO and
Rhesus blood groups, secretor status, PTC taste perception and haemoglobin
variants in Osun State, Nigeria and previous studies have been based on
heterogeneous population. We wanted to have information on the frequency
distributions of these traits in Osun State and among a homogeneous population. A
total of 555 individuals comprising 308 male and 247 female indigenes of Ore
community participated in this study. Participants’ blood samples were typed for
ABO, Rhesus blood groups and haemoglobin genotype, saliva samples were
analysed for ABH secretory status and PTC taste perception was determined using
PTC strips. The frequencies of O, A, B and AB individuals were 41.6%, 30.8%,
21.6% and 6.0% respectively, those of Rh positive and Rh negative were 89.9% and
10.1%, those of secretors and non-secretors were 69.2% and 30.8% respectively
while those of tasters and non-tasters were 56.6% and 43.4% respectively. The
observed ABO blood group, Rhesus factor, secretor status, PTC taste perception
distributions did not differ significantly (p = 0.986, p = 0.943, p = 0.926, p = 0.864
respectively) from those expected under the Hardy-Weinberg equilibrium. The
allelic frequencies for ABO were p(A) 0.205, p(B) 0.149 p(r) 0.645, those for
Rhesus factor were D(0.682) and d(0.318), those for secretion and non-secretion
were Se (0.445) and se(0.555) respectively while those of tasting and non-tasting
were T(0.341) and t(0.659) respectively. Four haemoglobin genotypes in the order
AA (68.6%) > AS (26.7%) > AC (3.8%) > SS (0.9%) were observed with allelic
frequencies A(0.839), S(0.142) and C(0.019). This study has provided information
on the frequency distributions of the studied genetic indices in Osun State. The
information provided herein can be used to give medical and genetic counsel to the
people of the State.
ORIGINAL RESEARCH ARTICLE | Feb. 28, 2018
The Effect of Transformational Leadership and Work Environment to Employee’s Performance
Didin Hikmah Perkasa, Neneng Saidah, Hapzi Ali
Page no 158-164 |
10.21276/sjbms.2018.3.2.7
This study aims to determine the effect of transformational leadership and
work environment on Employee’s performance. The object of this study was
employees of PT Pegadaian branches Meruya West Jakarta. The population in this
study was 40 employees. The results of this research used saturated sampling
technique. Data collecting used questionnaires and subsequent, then data analyzed
using multiple linear regressions. Data processing for statistical tests performed with
SPSS 21. The results showed that both independent variables of transformational
leadership and significant positive effect on Employee’s performance, while for the
working environment variable was not significant or positive effect on Employee’s
performance.
REVIEW ARTICLE | Feb. 28, 2018
A Critical Review of Food Crisis in Pakistan
Hani Fatima, Muhammad Faizan Khalil , Aleen Fatima
Page no 284-286 |
10.21276/sjhss.2018.3.2.17
Pakistan is a low income country and the development of agriculture is
its most important sector, due to its major commitments Provide healthy food for
people. In the past 60 years, the aquaculture area in Pakistan has increased.40%,
the rise of the more than 4 period of the masses and the seven times that of the
urban development arousing the growing pressure on the cultivated land. Although
the yield of wheat has increased by five times, the country is but it's marginal
importer. Because of the public's development, the gap between food demands has
narrowed to an unbelievable level. Domestic grain production. To deal with food
protection in Pakistan needs to know about agriculture (Malik, 2015).
ORIGINAL RESEARCH ARTICLE | Feb. 28, 2018
The Influence of Career Path and Organizational Culture on Employee Performance (Case Study at PT Tri Daya Selaras)
Hasan Nuryadi, Muhammad Rizal, Hapzi Ali
Page no 151-157 |
10.21276/sjbms.2018.3.2.6
This study to determine the effect of career path and organizational culture
on employee performance. The object of this research is employees of PT.Tri Daya
Selaras This research was conducted on 58 respondents by using descriptive approach
quantitative. Therefore, the data analysis used is the analysis in the form of multiple
linear regression tests. The results of this study indicate that partially and
simultaneously, career path variables and organizational culture affect the performance
of employees of PT Tri Daya Selaras. This is evidenced from the results of partial test
(t test) and the accuracy of the model also shows the significant value of two
independent variables that support the hypothesis.
REVIEW ARTICLE | Feb. 28, 2018
Do We Have To Play With Our Children? Is It Needed?
Rinju Joy, Anuradha Sathiyaseelan
Page no 274-278 |
10.21276/sjhss.2018.3.2.15
No parent is born a parent rather parenting is a process wherein a parent
grows from an individual state to being a parent. Parents shape a child’s whole
childhood and in the process of shaping ‘play’ occupies a major role and it fosters
the parent child relationship. Play in childhood doesn’t just reflect the current level
of development in the child but rather it seems to take forward its effect throughout
the life of the child and helps parents understand the child’s perspective easily. For
a child, play is not just a play but it is a way of self expression. Playing with the
child gives child a sense of being important to the parent this later facilitates a
sense of optimism in the child. Being a parent is never an easy role to go about, it
calls for a lot of effort often parents are torn between the parenting roles and
professional role. Especially in the Indian scenario parents playing with their kids
are often valued less and it is not considered as an important element in child
development. The advent of technology too has a very important role to contribute
to the devaluing of play in today’s world.