The present study examined the anticonvulsant activity of the methanol stem bark extract of PK in mice and day old chicks against maximal electroshock (MES), pentylenetetrazole (PTZ), picrotoxin (PIC), and strychnine (STR) induced seizures. The CNS depressant ability of the extract was also investigated using diazepam-induced sleep test, and it was observed to significantly and dose dependently increase the sleep duration in the diazepam sleep test. The extract and fractions significantly and dose dependently increase the latency to onset of seizure in the PTZ and picrotoxin tests. In the strychnine test, the extract significantly increased the latency to seizure onset at the highest dose of 200 mg/kg, though none of the mice was protected from seizure as was the case with PTZ and PIC induced seizures. Considering the overall effect of PK, it may be concluded that the extract contains bioactive principles acting via enhancement of GABA inhibitory activity, and a second possibility via antagonism of the glutamate-NMDA receptors

Over the course of the last three decades agile project management has by far become the preferred approach to project management being employed by today’s organisations. The online and fast paced nature of today's market place has meant that organisations need to be able to deliver their projects much quicker and in shorter time frames then in previous times. A new way of working has meant that existing areas of project management have needed to evolve to align with this new way of working. One such area is that of risk management. Risk management plays an integral role in the success both of a project and the organisation itself. This manuscript aims to review how risk management can be performed within an agile project management framework.

In the present investigation the chemical effect on colour fastness of Phyllanthus muellerianus dyed wool was studied. Samples were assessed in terms of the colour fading to spotting with dilute hydrochloric acid, with 56% acetic acid, steeping for two minutes at room temperature in 28% ammonium hydroxide without rinsing, exposed to concentrated ammonia fume for 24 hours and spotting with 10% sodium carbonate and calcium hydroxide respectively. Contact with dilute hydrochloric acid brings about significant changes in the color and fastness properties of natural dyed wool yarn. The colours however, remain stable after exposure or contact with alkalis and 56% acetic acid. It can be concluded that Phyllanthus muellerianus dyed wool fabric have good colour fastness to perspiration and except with mineral acids.

The study is an ecotoxicological evaluation of commercial fish farm in Ogbogoro (OGB), Rivers State Nigeria using anatomical/macro morphological assessment of Clarias gariepenus, and African Aquaculture Centre (ARAC) as a the reference site. The sampling involved harvesting of table-sized fish: twenty fishes from OGB and ten fishes from ARAC. The gross anatomy (fish necropsy) involved the determination of Fish Biometry (Condition factor, CF and Organosomatic Indices, OSI) and Health assessment index (HAI). Showed that: fishes from OGB were less healthy based on the CF; OGB were less Healthier based on OSI; OGB fishes were less Healthier based on HAI when compared to fishes from ARAC. It was concluded from the study that the fishes from Ogbogoro fish farm had certain level of pollution though considered to be moderate at the time of the study.

Fistula in Ano is a simple anorectal condition, however, has the potential to cause high morbidity. The usual line of surgical treatment for simple fistula in ano includes fistulotomy with marsupialization and fistulectomy. The present study was aimed to determine the overall outcomes after treatment of patients with fistulotomy with marsupialization and fistulectomy and compare the results in terms of post-operative complications and recurrences. Methods: The study involved 70 patients diagnosed with simple fistula in ano. Patients with morbid medical conditions and those diagnosed with complex fistulas were excluded from the study. The Clinical examination included perineal inspection, palpation, digital rectal examination and proctoscopic evaluation. The patients were then randomly divided into two groups. The group I patients underwent fistulectomy and the group II underwent fistulotomy with marsupialization. The patients were operated under general or regional anesthesia. The anorectal examination was done to verify the findings of the clinical examination. The patency of the tract was checked using the probe to the external opening. Seventy patients diagnosed with simple anal fistula were involved in the study. The mean distance of external fistula opening in group I was 2.6 ± 0.54 cms and the mean distance in group II was 2.5 ± 1.05. The duration of symptoms in group I and group II was 7.60 ± 2.9 and 8.85 ± 3.2 weeks respectively. The mean duration of surgery in group I was 12.5 ± 2.2, was 9.95 ± 1.25 in group II. Post-operative healing of the wounds was earlier in group II 4.06 ± 0.95 as compared to group I 5.15 ± 2.5. The mean VAS score was calculated on the 3rd postoperative day in both the group of patients. In group I the mean VAS score was 2.25 and the mean VAS score in Group II was 2.25. No patient in the study developed the wound infection and none had other complications. Conclusions: Within the limitations of the present study it can be concluded that fistulotomy with marsupialization and fistulectomy are equally effective in terms of the outcomes of treatment of simple fistula in ano. Although fistulectomy requires longer post-operative healing and the mean VAS scores were higher in the fistulectomy group then compared to fistulotomy group. No recurrence and occurrences of complications were noted in both the groups.

All this time many parties including parents do not care about the distribution of healthy information on sexual content to their adolescents so that many of them look for the information through social media. Right now the spread of websites with pornographic content occurs in social media including YouTube. This research aims at knowing the perception of adolescents on pornographic content in social media in relation to the influence of media information or the attitude of parents. It is the quantitative research with survey methods and data analysis using path analysis. The research results indicate that the attitude of parents on pornographic content in social media, YouTube gets influence from media information, and the perception of adolescents on pornographic content in social media YouTube gets influence from the attitude of their parents as well as media information gets influence the perception of adolescents on pornographic content in social media, YouTube. To avoid the negative impact of pornographic content in social media, parents should be more care about their adolescents particularly the planting of strong foundation on morality and religious teaching concepts to them.

Abstract:Thyroid hormones have many important biological functions in our body. One of the major functions is control of the basal metabolic rate and calorigenesis. Thyroid dysfunction causes remarkable changes in glomerular and tubular functions. In recent studies, it was found that hypo and hyperthyroidism associated with renal derangement resulting in abnormal serum creatinine and uric acid levels. Thus, this study was conducted for estimation and observation of changes in urea and creatinine in subclinical hypo and hyperthyroidism.Total 90 subjects were included in the study. Out of which 30 cases were clinically diagnosed subclinical hypothyroid patients and 30 were subclinical hyperthyroid, remaining 30 were controls. Triiodothyronine (T3),Thyroxine(T4), and TSH were estimated by fully automated Beckman coulter Access-2 analyser. Urea, uric acid and creatinine parameters were measured using automated clinical chemistry analyser. Statistical data analysis was performed by using SPSS 18.2 software. Patients with subclinical hypothyroidism showed significant increase in serum uric acid and creatinine levels (p<0.0001) and patients with subclinical hyperthyroidism showed significant decrease in serum creatinine levels (p<0.0001). When correlated with TSH, serum creatinine showed positive correlation where it has negative for serum uric acid in case of SC hypothyroidism cases. For SC hyperthyroid cases, correlation was negative for serum creatinine and uric acid levels.The overall result of our study indicate that the urea, creatinine, uric acid levels were significantly impaired in subclinical hypo and hyperthyroidism. Therefore, we would emphasize the importance of the routine evaluation of these biochemical parameters in thyroid disorders.

Background: Like in other developing countries, cancer of cervix is one of the leading malignancies in women in Nepal. In Nepal cervical pap-smear screening is not done my most of woman due to lack of awareness. The objective of this study is to find the prevalence of abnormal cervical epithelial lesions. This was a retrospective study of 396 conventional cervical Pap smears reported from the Department of Pathology, Birat Medical College in Biratnagar, Nepal. The time period was from March 2016 to March 2018. We used Bethesda system to report our all our slides. We used the pap stain to use the slide. All the case was reviewed by consultant pathologist of Birat medical college. Total cases were 396 in two year period in which 396 cases were satisfactory for evaluation and 20 cases were unsatisfactory for evaluation which is due to thick neutrophilic exudates, mucous, degenerative cells and hemorrhage. Out 0f 396 cases 7 cases is ASCUS that is 1.76%,4 cases is LSIL that is 1.01%,3 cases is HSIL that is 0.75%,1 cases is SCC that is 0.25%.Negative for intraepithelial lesion and malignancy is 381 that is 98.21%

In the past 15 years, awareness concerning natural changes was evidently expanding among population and industries. International agencies and national governments have expanded their endeavors concerning natural resources depletion, ozone depletion, gas emissions and waste reduction. Therefore, the main purpose of this paper is to examine the existing literature on the relationship between just-in-time (JIT), total productive maintenance (TPM), total quality management (TQM) and organisational performance. In total, 20 articles were empirically reviewed, all published in peer-reviewed journals between 2014 and 2018. The articles are analysed in terms of several general variables such as type of research and theoretical viewpoint, and the perspective taken on organisational criteria. The empirical reviewed indicated that JIT, TPM and TQM, maintained by human resource practices, have a significant prospective to develop the organisational performance. However, a simultaneous implementation of JIT, TPM and TQM does not certainly lead to greater performance. As prospective purpose for this, human resources are viewed as restrictive factor both improvement programs draw on. Therefore, this limited resource is acknowledged as vital element with respect to organisational performance when implementing JIT, TPM and TQM concurrently.

This review assesses the impact of waterlogging and submergence on crop physiology and growth of important crops in Bangladesh along with its remedial measures. Waterlogging can take place because of heavy rainfall, inadequate drainage systems, natural flooding etc. Oxygen levels diminish very rapidly in waterlogged root environment. So, damage of crops depends on duration and severity of flooding. The oxygen deficient conditions hamper plant growth, development and survival based on their tolerance to excess water. Under such environment plants exhibit metabolic switch from aerobic respiration to anaerobic fermentation, resulting in reduced rate of energy production by 65-97%. Anaerobic roots may also die from self-poisoning byproducts of anaerobic metabolism. The flooding also impedes the diffusive escape and/or oxidative breakdown of gases such as ethylene or carbon dioxide resulting in its accumulations. The accumulated ethylene may slow root extension, while carbon dioxide can severely damage roots of certain species. Moreover, waterlogged plants often face the oxidative damage induced by the generation of reactive oxygen species. However, all the plants have the ability to detoxify the adverse effects of reactive oxygen species (ROS) by producing different types of antioxidants such as ascorbate peroxidase (APX), superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), glutathione reductase (GR), ascorbic acid, glutathione, tocopherols and carotenoids. Prolonged exposure of plants to flooding conditions could result in root injuries which in turn restrict photosynthetic capacity by inducing certain alterations in biochemical reactions of photosynthesis. Waterlogging is also known to induce adverse effects on several physiological and biochemical processes of plants by creating deficiency of essential nutrients like nitrogen, magnesium, potassium, calcium. Species with inherently surface-inhabiting root systems are notably tolerant of prolonged waterlogging. There are several options for mitigation of submergence and waterlogging problems like breeding of waterlogging tolerant varieties, improvement of drainage systems and changing in crop husbandry. Providing adequate drainage, foliar spraying of fertilizers and hormones can alleviate waterlogging problems. Bed planting in waterlogged prone areas and floating beds in flooded areas are good options for high value crops.

This work is aimed at examining the effect of heavy metal concentration on surface water quality. This study was concentrated on the lower Niger River from Illah through Asaba/Onitsha to Okpai (Lat 6o 25' to Lat 5o 40' N and longitude 6o 37' to 6o 47' E). The data collected from water and were analyzed for the heavy metals (Zn, Cu, Pb, Cd, Ni, Fe, Mn and Co) using urican 929 Atomic Absorption Spectrophotometer. The results showed that Turbidity, BOD, TSS, hydrocarbon, coliform, magnesium and iron concentrations in the sampled settlement did not meet the WHO (2010) threshold for drinking water quality. The following conclusions were reached; the Niger River water must be treated before drinking, to remove or reduce the amount of non-essential or essential heavy metal and eating of fish species that have bio-accumulated heavy metals above the WHO limits for consumption must be prohibited or discouraged. Also, further studies should be carried out to monitor the heavy metal concentration in the lower Niger River and to identify the point sources of entry; and various contributors to the contamination of the River Niger. Heavy metals have however been grouped into two categories – Essential and Non-Essential. Zinc, Iron, Manganese, Copper and Cobalt are essential and beneficial elements but become toxic when their concentrations exceed those required for normal life Lead, Arsenic, Beryllium, and Mercury are non-essential and are not required in biological systems because they are toxic. The following recommendations were made; frequent environmental monitoring (at least twice a year) must be conducted to know levels of heavy metals contamination especially of the aquatic systems; Education of the neighbouring populace on protection of the environment through various technical programmes may very useful; The Niger River water must be treated before drinking, to remove or reduce the amount of non-essential or essential heavy metal such as Cr and Fe; The eating of fish species that have bio accumulated heavy metals above the WHO limits for consumption must be prohibited or discouraged; Further studies should be carried out to monitor the heavy metal concentration in the lower Niger river and to identify the point sources of entry; but, the result of this study should form the baseline data for the assessment of the various contributors to the contamination or otherwise of the River Niger. Thus, the pollution trends in the future can easily be monitored.

In the present world, due to tremendous development in technology, a huge amount of information is available everywhere. Therefore, it is difficult for the users to understand the main content of the entire document as it takes a lot of time. In this work we use extractive text summarization which uses a method to give the version of summary for one or more file or document. Here we give an approach that maps sentences to nodes of a hierarchical ontology. Ontology explains what exists in a particular domain. For the ontology creation, vocabularies are collected. It is used as background knowledge and helps to find the related meaning of the terms which occur in the source documents. Text mining is the technique from which high quality information is derived from text. Clustering is a significant task. The clustering method groups similar or related terms into a single group. In the first stage, data collection takes place. The preprocessing stage includes stemming and stop words removal.TF-IDF process occurs after which clustering takes place. In the ontology creation, first the determination of the main sub topics of the article of interest is done. We classify sentences to nodes which have a predefined hierarchical ontology. Each ontology node has bag-of-words from a web search. We represent sentences by sub trees that permit to apply measures of similarity and find relations between sentences. The ontology used in this work is not domainspecific; it does not require labelled data. this work can be extended to topics focused on summarization framework to news articles or blogs and to also to various machine learning approaches

This study investigates the importance of critical thinking skills for domain specificity. A theatrical research is carried out to highlight the use of critical thinking skills for domain specificity. Literature highlights that students use their critical thinking skills in a specific domain and perform better in classroom and at work place. Literature further highlights that teachers must facilitate students in the knowledge of critical thinking skills by using their own critical faculties. Likewise, advocates of critical thinking stress that institutes must produce critical thinkers. Literature focuses on domain specificity for the use of critical thinking skills. Studies show that in a specific domain learners critically comprehend, analyze, infer and evaluate text and finally become critical thinkers in a specific domain.

Oncogenesis is a very complex and multistep process with many factors involved. Among the various cancers viral oncogenesis constitutes about 12%. The human population has been plaqued by viruses particularly viruses with oncogenic potential. Worldwide, viruses cause numerous miseries ranging from flu to complex cancers. A noteworthy few among them are caused by oncoviruses such as Human papilloma virus, Hepatitis B, Hepatitis C, HTLV-1, EBV. Among these viruses Human papilloma virus and Human T Lymphocyte virus have direct oncogenic potential whereas HIV, EBV, Hepatitis B and Hepatitis C have indirect oncogenic potential. In this review, we aim to discuss briefly about the pathogenesis of the most commonly 6 occuring oncoviruses and their oncogenic potential.

The challenge for today is not just retaining talented people, but fully engaging them, capturing their mind and hearts at every stage of their work lives. Employee engagement has emerged as a crucial driver of business success in today’s competitive marketplace. Further, employee engagement can be a key factor in organizational success. Not only does engagement have the potential to significantly affect employee retention strategy, productivity and loyalty, it is also a key connect to customer satisfaction, company reputation and overall stakeholder value. Thus, to gain a competitive edge, organizations are looking to HR to set the agenda for employee engagement and commitment. Employee engagement is rightly a property of the relationship between an organization and its employees. An "engaged employee" is defined as the one who is fully absorbed by and enthusiastic about their work and so takes positive action to further the organization's reputation and interests. Employee engagement is a way ahead to business success. An engaged workplace is one encourages commitment, energy and productivity from all those involved to help improve and achieve business performance. Employee engagement is about linking on our employees’ knowledge and ideas to improve our products and services, and be innovative. Employee engagement is about indulging a deeper commitment from our employees so fewer leave, sick absence reduces, accident rates decline, conflicts and grievances go down, productivity increases. Employee engagement is about organisation actions that are consistent with the organisation’s values. This paper is an attempt to review the available literature in the field of employee engagement which are in the form of models and draw conclusions on the available gap. It is purely based on secondary data