Preeclampsia is a pregnancy complication characterized by high blood pressure and damage to organs such as the liver and kidneys. Despite its severity, the pathophysiology of preeclampsia remains poorly understood, and early diagnosis is a significant challenge. This prospective case-control study aimed to investigate the potential of serum endoglin (sEng), interleukin-6 (IL-6), and interferon gamma (IFN-γ) as diagnostic biomarkers for preeclampsia. The study was conducted at Asaba Specialist Hospital, a tertiary hospital with Antenatal Clinic in Delta State, Nigeria. Sixty participants (30 preeclamptic (on set) and 30 healthy pregnant controls (during clinic) was determined using G*Power Software and were recruited based on inclusion and exclusion criteria after approval was obtained from the Ethical and Research committee of the hospital and informed consent taken from participants. Blood samples were collected and stored at above -20°C until analysis. Statistical analysis was performed using SPSS version 25. The main findings of this study were that sEng, IL-6, and IFN-γ levels were significantly higher in women with preeclampsia compared to controls (p < 0.05). The ratio of sEng, IL-6, and IFN-γ between preeclamptic patients and healthy controls was 4:1, 2:1, and 2:1, respectively. The ROC analysis reveals an excellent diagnostic accuracy of the biomarkers with the area under curve (AUC) of 0.98, 0.99 and 0.99 for sEng, IL-6, and IFN-γ respectively. This demonstrates the potential of serum endoglin, IL-6, and IFN-γ as diagnostic biomarkers for preeclampsia. The findings support their use in clinical practice to improve diagnosis, treatment, and patient outcomes, providing new insights into the pathophysiology of preeclampsia with regards to endothelial dysfunction, inflammation and immune dysregulation and may inform the development of novel therapeutic strategies for preeclampsia, providing avenues for the prevention and treatment of the condition.

The Pro Kabaddi League (PKL) has played a pivotal role in transforming Kabaddi from a traditional sport into a highly popular professional league format, attracting mass viewership across India and abroad. The sport’s visibility has further risen with the recent victories of both the men’s and women’s national teams at the Asian Games, which have significantly boosted public interest and fan following. Against this backdrop, the present study focused on examining the performance of the Gujarat Giants (GG) team across five PKL seasons, specifically from Season 5 to Season 9. A total of 166 matches were analyzed, and performance indicators such as Total Points, Total Raids, Total Raid Points, Total Tackles, and Total Tackle Points were taken into consideration. To determine whether performance varied between seasons, an ANOVA test with LSD Post-Hoc analysis was employed. The results revealed statistically significant differences (p < 0.05) in all key performance areas across the seasons, highlighting the dynamic nature of team performance. This type of performance analysis is crucial for Kabaddi, as it offers insights that can inform team strategies, enhance player development, and support data-driven decision-making for coaches, analysts, and management. Ultimately, it strengthens competitive preparation in an evolving professional sports landscape.

Thrombocytopenia is the second most common haematological finding in pregnancy next to anaemia. Platelet count below 1.5 lakh/cu mm. It carries a risk for both the mother and the fetus, associated with substantial maternal or neonatal morbidity and mortality. However, a specific therapy, if instituted promptly, improves the outcome for affected patients and their offspring. In patients in India, thrombocytopenia during pregnancy is an under explored condition. After taking consent from patients detailed history of period of gestation, high risk factors, past history, complications-during present and past pregnancy. History of petechiae, bruising, drug usage, viral infection, thrombocytopenia in previous pregnancy will be taken. General, systemic and obstetric examination will be done. All women platelet count estimation at the time of enrollment. Platelet count assessment will be done through automated blood count analyzer with routine antenatal hematological evaluation of the patient. In this study, there were 53.3% cases of mild thrombocytopenia, 33.4% of moderate thrombocytopenia and13.3%with severe thrombocytopenia. Gestational thrombocytopenia is the most common etiology .60 % of cases delivered at term, those delivered before term were mostly due to abruption or pregnancy was terminated for obstetric indications like severe preeclampsia, antepartum eclampsia, abruption or medical causes. Mode of delivery is not influenced. GT is the most common cause of thrombocytopenia during pregnancy (70%).

Sickle cell disease (SCD) remains a major global health burden characterized by chronic pain, inflammation, and psychosocial stress. While pharmacological approaches like hydroxyurea offer partial relief, integrative therapies including Ayurveda based sound and mantra therapy provide supportive, culturally appropriate options. This paper reviews the evidence and principles behind the use of sound healing, mantra chanting, and music-based interventions in SCD management, highlighting their roles in pain relief, stress reduction, emotional stability, and quality of life improvement.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly observed in lean individuals, particularly in non-Western populations. In this prospective Moroccan study, 100 patients with biopsy-proven MASLD were divided into two groups: lean (n=50) and non-lean (n=50). Lean patients were older and displayed a lower prevalence of classical cardiometabolic risk factors such as obesity, diabetes, and metabolic syndrome. However, they more frequently presented with autoimmune comorbidities, suggesting a distinct immuno-inflammatory background. In contrast, advanced fibrosis was significantly more prevalent in non-lean patients. These findings support the notion that lean MASLD constitutes a separate clinical entity with unique risk profiles, highlighting the need for individualized diagnostic and therapeutic approaches.

Access to safe and clean water is a major challenge in many rural communities of Abia State, Nigeria. Due to the absence of adequate water treatment facilities, residents in these areas depend largely on untreated surface water from rivers, streams, and ponds for domestic, agricultural, and sometimes industrial purposes. This study investigates the environmental effects of untreated surface water in selected rural areas of Abia State, with emphasis on its physical, chemical, and microbiological qualities, and their implications for public health and the ecosystem. Field sampling and laboratory analyses were conducted on multiple surface water sources in rural communities. The results reveal that these waters contain significant levels of turbidity, suspended solids, and colouration exceeding World Health Organization (WHO) permissible limits. Chemical analyses indicated the presence of undesirable mineral concentrations, including high nitrate and phosphate levels from agricultural runoff, and traces of heavy metals such as lead and cadmium. Microbiological tests confirmed the presence of Escherichia coli, total coliforms, and other pathogenic organisms, indicating faecal contamination. These findings suggest that the continued use of untreated surface water poses a dual threat: increased risk of waterborne diseases such as cholera and typhoid, and environmental degradation including eutrophication, biodiversity loss, and soil contamination. The study concludes that urgent interventions—including community-level treatment systems, stricter water protection policies, and sustained public health education—are necessary to mitigate the negative impacts and promote sustainable water management in rural Abia State.

The connecting factor formula is a distinctive concept in private international law and serves as a universal rule for resolving conflicts of laws. This paper examines the influence and role of private international law theories in the formation and development of connecting factor formulas by analyzing different stages of doctrinal evolution and representative scholarly perspectives. The study aims to provide a theoretical foundation for understanding and applying these formulas.

This study investigated the effect of interlocking board membership on financial performance of publicly quoted companies in sub-Saharan Africa. Ex-post facto research design was adopted and secondary data were obtained from yearly audited annual reports and accounts of publicly listed companies. The study was conducted using sixty (60) publicly listed companies drawn from all sectors in three (3) countries of sub-Saharan Africa namely; Nigeria, Kenya and South Africa, from 2013–2023. Data obtained were analyzed using descriptive, post-estimation, and inferential statistical techniques. The estimation technique was the generalized method of moment and the results revealed that interlocking board membership insignificantly influence financial performance proxied by return on assets of the publicly listed companies in sub-Saharan Africa. The implication of the finding is that board interlocking board membership is not a major driver of performance of quoted companies in sub-Saharan Africa. The study recommends among others that interlocking board membership should not be encouraged as the study found it insignificant in explaining financial performance.

Anatomy has always been the cornerstone of medical science, providing the essential basis for diagnosis, surgery, and therapeutics. While modern anatomy relies on dissection and microscopic techniques, its origins lie in the traditions of Greek physicians and the scholarly contributions of Arab and Islamic medicine. Within this heritage, the study of Tasrῑḥ Shaḥm wa Áḍalāt (anatomy of subcutaneous fat and muscle) highlights the integration of descriptive observation, philosophical reasoning, and clinical application. Greek physicians like Galen laid the groundwork with detailed, albeit animal-based, descriptions of muscles, tendons, and subcutaneous tissues, influencing subsequent generations despite notable inaccuracies in human applications. Arab scholars, building on these translations via institutions like the House of Wisdom, advanced anatomical understanding through systematic dissections and clinical observations, particularly in soft tissues such as subcutaneous fat (shahm) and muscles (aḍalāt). This synthesis not only preserved but enriched Greco-Roman texts, setting the stage for medieval medical progress. Through an analysis of primary Unani manuscripts, historical commentaries, and modern anatomical references, the works of Hippocrates, Al-Rāzī, Al-Majūsī, Ibn Sīnā, Al-Jurjānī, Ibn Rushd, Ibn Hubal al-Baghdādī, Ibn al-Quff, and Al-Masīḥī were examined. Their observations not only contributed to theoretical anatomy but also influenced practical medicine, such as methods of pulse detection, surgical approaches, and interpretations of disease. The comparison between classical and modern anatomy reveals that while ancient scholars provided largely descriptive and functional insights, contemporary anatomy has advanced these ideas with histology, imaging technologies, and biomechanics. Fat (shaḥm) was described as a nutritive reserve and protective cushion, whereas muscle (áḍalāt) was identified as the organ of movement, strength, and resilience. These early views, while framed in pre-modern contexts, share meaningful continuities with contemporary understandings of physiology. This review explores the perspectives of classical Greek and Arab scholars on fat and muscle, emphasizing their significance in both structure and function.

Coronaviruses are a large family of viruses that cause a variety of illnesses, from the common cold to severe acute respiratory syndrome. The SARS–COV–2 outbreak was first reported by the World Health Organization in China and has now become an epidemic, reflecting the extremely high transmissibility of the virus, which has caused great concern and stress among people around the world. Research suggests that prevention, risk education, and promotion of self–care behaviors can slow the spread of the disease in communities, and identifying sources of transmission can be effective in controlling it. The mortality rate of this virus is significantly higher in the elderly and people with underlying diseases compared to healthy people. Coronavirus is a challenging disease and can be easily transmitted in public places, and the number of people infected with this virus is increasing exponentially across all ages and groups. Therefore, increasing public awareness of this disease and providing positive psychological programs and teaching prevention methods in the media can reduce mental problems in society, in addition to reducing mortality and the number of patients.

The area under castor oil cultivation in Iran has varied over the years. In 2019, the area under castor oil cultivation in Iran was about 11.02 thousand hectares, according to the FAO report (FAO, 2021). This is while in 1996, the area under castor oil cultivation was higher and then decreased. Castor oil can be extracted using a variety of methods, including cold pressing, solvent extraction, and screw pressing. These methods utilize different tools and techniques to separate the oil from the castor seeds. Deserts are often associated with areas of high atmospheric pressure, particularly subtropical high-pressure zones. This high pressure is due to sinking air, which warms and dries, leading to low rainfall and desert conditions. Conversely, low-pressure systems typically bring cloudy, rainy weather, not desert conditions. Chromosomes are string-like structures that store genetic information and are located in the cell nucleus. These structures are made up of DNA and protein and pass genetic information to new cells during cell division. The number of chromosomes in a castor bean seed is 20 (2n=20). This number means that each castor bean cell has 20 chromosomes, which are located in pairs (10 pairs) in the cell nucleus. Castor (Ricinus communis) is important in Iran as a valuable plant, both medicinally and industrially. Castor oil is traditionally used in traditional medicine for various treatments and is also known as an important source for oil production in industry. In this research we concluded that castor bean plants can be cultivated in desert environments, particularly in arid and semi-arid regions, due to their drought tolerance and adaptability to various soil types. While they prefer well-drained, fertile soil and a specific temperature range, castor beans can thrive with minimal rainfall and even tolerate slight soil acidity. Their deep-rooted nature allows them to draw moisture from deeper soil layers, making them suitable for water-scarce regions. In this research we concluded that the toxicity of raw castor beans depends on the percentage and size of the ricin toxin. Although the lethal dose for adults has been identified as about 4 to 8 seeds, reports of human poisoning from these seeds are very rare. In addition we concluded that Castor beans contain a highly toxic protein called ricin. During the oil extraction process, high heat inactivates and destroys this protein. After processing and purifying castor ricin, the final product is completely purified and becomes usable. Castor oil is one of the oldest medicinal plants in the world. Determining the genetic diversity of plants, including castor oil, plays an important role in identifying superior genotypes for use in plant breeding programs. For this purpose, the genetic diversity and relationship of castor oil ecotypes, resistance to salinity, and response to organic and mineral fertilizers were investigated in this study.

Without pigments, life would lack vibrancy. The natural world presents us with a kaleidoscope of colours from the lush green grass of home to the warm, ruddy hues of an autumn forest. These colours, with few exceptions, arise from natural pigments found in living organisms. Beyond providing visual appeal, pigments fulfil essential biological functions. Among the various classes of natural pigments, carotenoids stand out for their wide distribution and diverse roles in biological systems. Lycopene a red carotenoid pigment, is abundant in tomatoes, apricots, guavas, watermelons, papayas, and pink grapefruits, with tomatoes serving as the primary source in the human diet. Notably, lycopene demonstrates a strong ability to quench singlet oxygen, making it a powerful antioxidant. Its vivid colour and lack of toxicity also make it a valuable natural food colorant. In addition to its antioxidant properties and use as a natural colorant, lycopene demonstrates considerable potential in both medical and dental fields. It has been recognized as an effective adjunctive, non-invasive therapeutic agent in the management of several oral diseases, including leukoplakia, oral submucous fibrosis, lichen planus, and oral squamous cell carcinoma. Furthermore, lycopene contributes to the preservation of periodontal health by preventing the breakdown of supporting tissues. This review highlights the mechanism of action, multifaceted role of lycopene, particularly emphasizing its preventative and therapeutic potential in managing a range of oral health conditions.

This research analyzes the impact of Financial Constraints, Income Shifting, and Sustainability Reporting on tax avoidance, with Institutional Ownership as a moderating variable. The sample consists of 34 manufacturing companies listed on the Indonesia Stock Exchange from 2021 to 2023, using purposive sampling methods. Data were analyzed using panel data regression with EViews 12. The results indicate that Income Shifting and Sustainability Reporting significantly affect Tax Avoidance, while Financial Constraints do not impact Tax Avoidance. Additionally, Institutional Ownership moderates the effect of Income Shifting on Tax Avoidance but does not moderate the effects of Financial Constraints and Sustainability Reporting on Tax Avoidance. This study meets classical assumption tests and found no issues with multicollinearity, heteroscedasticity, or autocorrelation. The findings highlight the importance of Institutional Ownership in monitoring tax avoidance and the need for transparency in sustainability reporting.

Diabetes mellitus (DM) is a significant public health and economic concern in Saudi Arabia, affecting more than 20% of adults. Insulin remains a cornerstone in DM management, but the country relies significantly on imported products. Hence, this results in high healthcare expenditures and variable availability. In line with Vision 2030, Saudi Arabia has prioritized the localization of insulin manufacturing to ensure sustainable access, reduce import dependency, and enhance national health security. This paper explores the clinical, economic, and policy implications of localizing insulin production in the Kingdom. The current work used a case study methodology to assess the feasibility, challenges, and strategic opportunities for the domestic production of innovative insulins, such as Degludec and IDegAsp. The study supports the development of public-private partnerships, investment in biotechnology infrastructure, and regulatory reform to foster a robust local biopharmaceutical ecosystem. By 2027, Saudi Arabia aims to meet 50% of its insulin demand through local production, making it the first country in the GCC region to produce innovative insulin. This initiative is expected to promote affordability and position the Kingdom as a leader in insulin innovation.

The inadequate supply of educational teaching aids and truly functional laboratories to aid teaching and learning of sciences across Nigeria, particularly Zamfara State, due to high cost incurred in acquiring them has necessitated the invention of a multifunctional mobile teaching aid and intervention laboratory for schools. The invention is a home-grown, purpose-built game changer to positively leverage the educational sector to enhance quality and effective Science, Technology. Engineering and Mathematics (STEM) education in Nigeria. Thus, the article x-rays banditry activities in Zamfara State and feasibility of integrating mobile-laboratory-intervention for skills acquisition in Zamfara State. The study adopted a mixed method research design using both qualitative and quantitative data. Four research questions and hypotheses were formulated to guide the study. The population consisted of 280 principals selected from three educational zones in Zamfara State using multi-stage sampling technique. A self-designed instrument was used for data collection. The questionnaire was subjected to face-and content validity by experts in education and gave a reliability coefficient of 0.85 using Cronbach Alpha reliability test. Mean and standard deviation were used for answering the research questions while t-test analysis was used in testing the hypotheses for the study at 0.05 level of significance. The findings revealed no significant difference in the opinion of the respondents on the impact of banditry activities on STEM education for skills acquisition in Zamfara State. The study recommended among others that the provision of multifunctional mobile laboratory intervention, organization of workshops and conferences on the significance of STEM education should be encouraged at all levels.