The case of a patient with a septal abscess is reported, with the aim of providing a comprehensive analysis of the diagnostic approach and the various stages of treatment, as well as prompting in-depth reflection on the implications that this particular case could have for medical practice in general. It also highlights the vital importance of early recognition of this condition, and of responding rapidly and appropriately to the patient's needs. It also highlights the value of clinical experience in improving the management of similar cases in the future.

Objectives: The objective of present study was to develop chitosan-based sustained release Levofloxacin microspheres to reduce the dosing frequency. Materials and Methods: The Levofloxacin -loaded microspheres were prepared by emulsification cross-linking method using glutaraldehyde as cross-linking agent. Accurately weighed quantity of Chitosan was dissolved in 1% (v/v) aqueous acetic acid. Results: The percentage yield of the emulsification cross-linking method was determined to be between 74 and 81.5 percent, and the spherical microspheres had particle sizes ranging from 2 m to 200 m. According to the in vitro dissolution analysis of the improved formulation (F2) (table 7.8), when the medication was enclosed in Chitosan microspheres, 95 percent of the formulation was released after 12 hours, demonstrating that the drug is released from the formulation in a controlled way. Conclusions: The percentage of entrapment effectiveness, particle size, and percentage of drug release were significantly impacted by the drug: polymer ratio and GA volume. According to research using scanning electron microscopy (SEM), microspheres were round and had a smooth surface. Nicorandil-loaded chitosan microsphere formulations released their drugs via fickian diffusion.

Drying is an important unit operation in the processing of fresh cassava tubers into cassava chips. An air flow meter is a device that measure airflow. Airflow meter and direction sensing are importance in many fields, including the monitoring on vehicle engine performance. The airflow meter for cassava chips measures how much air is flowing through the cassava chips. There are many reasons and ways to measure airflow, this technical method of explores the use of air flow meter to measure cassava chips in order to ensure the proper airflow to dry the cassava chip, which will improve the value chain of cassava processing. This research work focused on the design and performance evaluation of an airflow meter for drying cassava chips. The air flow meter was made from locally available materials and it consists of a blower, pressure, sensor, temperature sensor, heating chamber which was used to carry out several tests on cassava chips. From the test conducted during drying operation, at a temperature of 900c for a 372g of cassava chips, it takes a period of 180 minutes (3hours) with an airflow of 133m3/sec to dry it to a safe moisture content. At temperature 1100c for 617g of cassava chips, it takes a period of 240 minutes (4hours) with an airflow of 209m3/sec to dry it to safe moisture content. The efficiencies of the drying mechanism and measuring airflow device are 70% and 65% respectively. The sample dried with airflow meter still retain their white colours, thus indicating no mould growth.

This paper presents the steady-state thermal and static structural modelling of a laboratory-scale pyrolysis reactor for the thermal degradation of biomass wastes. A laboratory-scale pyrolysis reactor of volume 9.203 x 10-3m3 was developed to pyrolyse Palm Kernel Shell (PKS) and Palm Fruit Bunch (PFB) at varying temperatures of 350oC, 400oC, 450oC, 500oC, and 550oC. The reactor chamber was simulated for static-steady thermal and static structural analysis to determine the temperature distribution and thermal stresses induced in it. The model was developed using SolidWorks software, and a Computational Fluid Dynamics (CFD) simulation was carried out using ANSYS Workbench 19. A total number of 2,459 elements was generated composed of 8630 nodes using Hexahedra dominant meshing method. It was observed from the simulation result that the temperature distribution inside and outside the reactor chamber were 454.29oC and 550oC respectively. The maximum heat flux of 8.3466e+005 W/m² occurred at the inner chamber of the reactor due to the high concentration of the biomass waste and devolatization reaction, and the maximum equivalent (von-Mises) stresses the material can withstand at higher temperature is 1.6674e+009 Pa without rupture. It was found out from the simulation result that at a maximum temperature of 550oC, the equivalent (von Mises) stresses induced at the outer and inner chamber is 1.8585e+008 Pa, which is far lower than the maximum stress the material can withstand without rupture. Thus, the reactor is safe to operate at a temperature higher than 550oC without failure.

This work characterizes the geotechnical properties and microstructure that served as a fundamental and more practical basis for describing the hydraulic conductivity of the lime-treated cubitermes sp termite mound soil. The results show that changes in particle size lead to a decrease in dry density and linear swelling. Permeability is strongly correlated with particle size distribution and compaction. Permeability increases up to the lime fixation point obtained at 6% of the lime content. Compaction for micropore reduction in treated soil is higher than in raw soil. The treated soil has a denser internal structure with agglomerations of dispersed clay particles. The increase in compaction energy reduces macropores and permeability, and the soil microstructure becomes homogeneous. Natural soil is highly impermeable, and soil-lime mixes are among the least draining materials. Higher values of hydraulic conductivity were obtained as a function of time. Soil and mixtures can be used in civil engineering works (earthworks). Correlations between hydraulic conductivity and particle size fractions are polylinear fits with R2 (0.962-0.993) and the Slogistic1 model with χ²(2.06E-15) for the mean silt fraction. This study is decisive for predicting hydraulic conductivity from the geotechnical properties of the soil, by solving the mathematical expressions of the models used.

One of the directions for making cleaner and more economic vehicles is to adopt electric vehicle concept. Therefore, an internal combustion powered engine Nissan Micra Vehicle was converted into battery powered electric vehicle. The power train of the car was redesigned to use DC electric motor in replacement of the existing internal combustion engine and to give the gear ratios possibility of a normal car. The power rating of the motor was determined by considering the rolling, gradient and aerodynamic resistances which gave a total tractive effort of 12190.84 N. The designed power rating was then determined to be 8 kW and this value was used to select the number of batteries that gave the required current to reach an adequate range of operation. To balance the weight of the car, the battery rack was located behind the center of gravity to give the developed vehicle a neutral steer characteristic. After installation of electric motor, inverter and the batteries, then the batteries were connected in series and parallel to the inverter with cable wire via variable frequency drive to ac motor and potentiometer. The vehicle was then evaluated and the voltage produced was able to move the vehicle at 6.24 m/s and the maximum frequency obtained was fifty megahertz (50 MHz).

Introduction: Pilocytic astrocytoma is the most common cerebral glioma in pediatric age, preferentially located in the posterior cerebral fossa. Atypical presentations have rarely been described in the literature. Clinical Case: We report a case of pilocytic astrocytoma whose appearance on CT scan is unusual. It concerns a young boy of 9 years old, who presented convulsive seizures since the age of 6 years old, followed by general practitioners with irregular treatment based on gardenal. 2 months ago the seizures became more frequent and this prompted a specialist consultation with the neurologist, after a brain scan he referred the patient to us. The neurological examination was unremarkable today. Brain CT with contrast showed a right parietal lesion. It was a lesion with a double cystic and fleshy component associated with calcifications with heterogeneous enhancement which amputated the posterior horn of the lateral ventricle. The radiological appearance was in favor of a low-grade oligodendroglioma. The patient underwent surgery with complete macroscopic excision of the lesion. Histological examination revealed a pilocytic astrocytoma (grade I). Conclusion: The usual radiological appearance of pilocytic astrocytoma combines a cystic part and a highly contrasting mural nodule. It rarely presents in the form of a supratentorial lesion with calcifications. This form of presentation is rare and can lead to confusion with other gliomas. We can achieve healing for the patient with total excision.

Background: Over the last 10-15 years, dengue fever (DF) and dengue hemorrhagic fever (DHF) have become the leading causes of hospitalization and death among both children and adult. Carica papaya leaves juice is said to increase platelet count, reduce complication and duration of Hospital stay. Objective: This study aimed to determine the effect of Carica papaya leaf juice on duration of Hospital stay in child patients with DF and DHF. Methods: This randomized controlled trial was conducted among 77 children with DF and DHF. Patients were purposively selected from the inpatient department of Dhaka Shishu hospital from July 2018 to December 2019. Patients were randomly allocated in group A and group B. Group A patients received standard treatment along with a bottle containing C. papaya leaves juice 10 ml single morning dose 15 minutes after breakfast for three consecutive days and group B patients received only standard management as per the National Guideline for Clinical Management of Dengue Syndrome, 2018. Three patients in group A and two patients in group B dropped out from the study. Results: There was no significant difference between the groups regarding age, sex, mean duration, type and severity of fever between the groups (p>.05). In group A, the mean platelet count increased from 105000.00/ mL to 152428.57/mL after 48 hours and it reached to 212228.57/mL at 72hrs. In group B, the mean platelet count initially decreased from 129485.71/ mL to 91114.28/mL after 48 hours and then it increased to 96142.85/mL at 72 hours. There was highly significant statistical difference between group A and group B at 48 hours and at 72 hours regarding mean platelet count as p <0.001. Haematocrit values become significantly normal in group A than group B by 72 hours and p value ˂0.05. There was highly significant statistical difference between group A and group B regarding mean hospital stay as p <0.001. Conclusion: Administration of Carica papaya leaf juice shorten hospitalization in patients with Dengue fever and Dengue haemorrhagic fever.

Within the context of enterprise resource planning (ERP) systems, this study aims to investigate the critical intersection of master information integrity with business rules. Quality master data that is in line with defined business regulations is crucial to the potency of data management systems in this era where data is the foundation for informed decision-making. The complex interplay between acquire data quality and business rule creation, deployment, and enforcement in various organizational settings is the focus of this research. The study takes a holistic view of the interdependent nature of master data quality & business rules by integrating theoretical frameworks, empirical analysis, and case studies. This research seeks to enhance our understanding of the opportunities and challenges that organizations encounter when trying to optimize the management of their information processes by analyzing practical situations and industry best practices to identify the critical factors impacting data quality and how they interact with business rules. In addition, the study delves into the impacts of poor mastery data quality on business rule effectiveness, and, on the other hand, how clearly specified business rules can improve master data quality. Researchers hope that businesses will be able to use the findings to strengthen their data governance plans and create a more flexible method of data management. Keeping ahead of the competition in today's data-driven world requires a deep grasp of the connection between core information integrity and business regulations, since data remains a valuable strategic asset for organizations.

According to "Never Events", insulin administration errors are serious preventable adverse events that should not have occurred if adequate preventive measures had been implemented. The event "insulin administration error" is on the ANSM list published in 2012. The National Health Service's (NHS) "Never Events insulin" has developed a module on insulin therapy management entitled "Preventing insulin-related medication errors". Proper use and knowledge of insulin management can prevent these events. Our study presents the results of a survey designed to assess both the knowledge of healthcare personnel and a group of diabetic patients in the Souss Massa region of Morocco. Our survey was an opportunity to re-educate our patients and review the knowledge of a group of staff interviewed, underlines the important deficit in knowledge and practice of nursing staff and insulin-treated patients, suggests that urgent intervention should be considered, particularly with young nursing staff, and also to review the therapeutic education of insulin-treated diabetics in order to improve their knowledge and better prepare them for the advent of new generations of insulin.

In order to effectively deliver drug molecules to their intended targets in the body, different dosage forms are utilized. Adapting dosage forms to the specific needs of the modern era and the condition of the disease can enhance the provision of healthcare to those in need, particularly through the use of herbal and traditional (Unani and Ayurvedic) products. Ayurveda employs various classifications of dosage forms, such as Aushadha kalpana and Ahara kalpana. Aushadha kalpana can be further categorized into Primary kalpana (Panchavidha kashaya Kalpana) and Secondary kalpana. These classifications are based on the origin of the ingredients, including plant, animal, and mineral sources. Dosage forms can also be classified based on their physical state, such as liquid, semi-solid, and solid forms. Furthermore, dosage forms can be categorized according to their intended usage, including Bahya kalpana (external application) and Abhyantara kalpana (internal administration). The importance of employing various dosage forms in Ayurveda lies in making them compatible and palatable to patients, as well as increasing their shelf life. One significant classification within Ayurveda is the topical dosage form (Bahya Kalpana), which encompasses formulations like lepa Kalpana, Malhara Kalpana, and Upnaha Kalpana. This article focuses specifically on exploring the topical dosage forms in Ayurveda.

Background: Pneumatic dilation (PD) is often presented today as a “short term” treatment for achalasia but, in truth, it can last for years. our study aims to determine the short and long-term efficacy of pneumatic dilatation on clinical remission in a treatment-naïve achalasia patient. Materials and Methods: A single center retrospective, descriptive and analytical study conducted between January 2007 and September 2022. Treatment naïve patients with manometric diagnosis of primary achalasia (subtype I and II) were included. We evaluated the clinical outcomes; single vs multiple PD, complications, and estimated duration of effect. Results: 121 patients were included, (mean age 42,2±14,5; 53,8% male), 88,4% (n=104) underwent 2 PD and 11,6% (n=17) underwent 3 PD, 23,1% (n=28) needed repeated PD at one year, The PD procedure was completed without major complications in all patients. Patients with subtype II had a better response to PD than subtype I(p=0,003). In the long-term follow up (median time: 50 months), the mean Eckardt score was 2.2. A subsequent 35 mm dilatation was associated with long-term clinical remission than an initial dilatation with 35 mm.(p=0.003). On univariate analysis, the non-responders more often was male gender, had age< 40 years (p=0.0006), and had high baseline LESP (lower esophageal sphincter pressure>50 mmHg), p=0.004). On multivariate analysis only age<or= 40 years (p=0.02) was associated with poor outcome. Conclusion: PD is an effective, durable and safe treatment for achalasia. A graded-protocol PD starting with a 30 mm dilation applied in the appropriate achalasia subtypes was shown to be a highly effective approach, in both the short- and long-term. Age<40 years, male patients and hight LESP have poorer outcomes following PD.

Pituitary apoplexy (PA) is a rare clinical situation caused by pituitary infarction with or without haemorrhage. Although it is usually spontaneous, dopaminergic agonists (DA) are known to be predisposing factors, particularly Bromocriptine, more rarely Cabergoline. We report the case of a 31-years-old patient with a microprolactinoma who developed acute visual acuity loss due to pituitary apoplexy 5 months after taking Cabergoline. The evolution was marked by a considerable improvement of the visual state. Pituitary apoplexy is a rare situation. Often reported with Bromocriptine, PA can also occur with Cabergoline. Due to the high mortality and morbidity of apoplexy, it should be borne in mind that close monitoring is necessary when treatment with DA is prescribed and the patient should be informed of this risk. Although DA precipitate risk, treatment can be continued for hormonal and anti-tumour remission.

Introduction: Open appendectomy (OA) and laparoscopic appendectomy (LA) are the choices of treatment for acute appendicitis. However, laparoscopic approach is emerging for the benefits it provides, but it also sometimes may has some drawbacks like OA including fistula. Objective: This retrospective study aims to investigate the management of fistula in 50 post appendicectomy fistula patients. Methods: A retrospective study was done at MH Samorita Medical College & Hospital, Hi-Tech Surgicare Hospital & Piles Centre, Savar Specialized Hospital and Lab Zone Hospital Savar, Bangladesh during January 2019 to December 2023 from January 2019 to December 2023, among the patients who had underwent laparoscopic appendicectomy and open appendicectomy. The total study population was 50, among which 33 (66%) patients were in open appendectomy and 17 (34%) were in laparoscopic appendectomy. The patients’ age group included 10 years to 50 years of both male and female patients. P< 0.005 was considered significant in this study. Results: Out of total study population, 33 were from OA (66%) and 17 were from LA (34%) group. Most of the study patients were male, aged 21-30 years age group. Fistulogram found to be the commonly use method to diagnose fistula. Tuberculosis was found to be the frequent cause of post appendicectomy fistula. Conclusion: Post appendicectomy seems to have different outcomes with some adverse impact, fistula is one of them. The present study finds that the chances of post appendicectomy fistula is less in LA group compared to OA. Proper study and better investigation may bring this to null with time.

Renal pathologies following viral infections have become an emerging public health problem in both developed and developing countries. Diagnostic criteria are complex. In most cases, they involve correlation between clinical, biological and histological data, with occasional recourse to molecular biology techniques. Several mechanisms are involved in the pathogenesis of virus-related nephropathy, including virus tropism in the kidney, formation of immune complexes in situ or in the bloodstream, direct cytopathogenic effects, and multiple organ failure. The hepatitis C virus is responsible for three main types of kidney disease: membranoproliferative glomerulnephritis, cryoglobulinemia and membranous nephropathy. Hepatitis B virus is associated with membranous nephropathy, membranoproliferative glomerulnethritis, and IgA nephropathy. HIV (human immunodeficiency virus) infection is associated with several glomerular and tubular kidney damage. HIVAN (HIV-associated nephropathy), a specific entity mainly affecting Africans and African-Americans, presents as a rapidly progressive glomerulonephritis rapidly progressing to the terminal stage. Infections secondary to adenovirus, cytomegalovirus, epstein-barr virus, poliomavirus and coronavirus are often responsible for acute or chronic tubulointerstitial nephritis. Treatment is mainly symptomatic, based on nephroprotection measures, rarely combined with antiviral therapy. Prophylaxis with vacci-nation, when available, remains the best means of preventing viral nephropathy.