COVID-19, caused by the SARS-CoV-2 virus, has resulted in nearly 7 million deaths globally as of 2023 and remains a significant health challenge. Many patients continue to suffer from long-term complications, commonly known as "long COVID," for which no definitive cure has been found. This has prompted a surge in research on potential underlying mechanisms of immunity. In addition to scientific advancements, holistic approaches to recovery are gaining attention. This study explored the application of the Guan Yin Citta Dharma Door, a Buddhist practice, in addressing both COVID-19 infection and its post-infection sequelae. By presenting a case study using this method, we examined the role of karma and collective retribution in the manifestation and healing of COVID-19. The findings suggest that integrating Dharma practices may complement conventional medical treatments, providing a holistic path to recovery for COVID-19 survivors.

Examining end-of-life care considerations within an Islamic context, the discussion delves into the intricate nuances surrounding ECMO patients. Drawing from Quranic teachings and Hadith principles, it underscores the sanctity of life and emphasizes compassionate decision-making. Advocating for integrating religious perspectives in healthcare highlights the importance of open dialogues, consultation with religious authorities, and respect for individual values. Islamic beliefs on life, death, and destiny shape the discourse on end-of-life care, focusing on dignity and quality of life preservation. Proposing a compassionate approach to ECMO discontinuation, the narrative emphasizes early consultations, transparent communication, shared decision-making, and advanced care planning for a dignified end-of-life journey.

Background: End-stage heart failure patients awaiting heart transplant often require Ventricular Assisted Devices (VAD) to support systemic and pulmonary circulation and to improve ventricular function, symptoms, and Health-Related Quality of Life (HRQoL). This study evaluates the health-related quality of life in patients with VAD and was conducted at the Cardio Ventricular Assisted Devices Clinic at King Faisal Specialist Hospital and Research Centre, Riyadh. Methods: This retrospective cohort study design included all eligible VAD patients who were still attending the cardio ventricular assisted devices clinic at KFSHRC, Riyadh. Each study participant was assigned a detailed questionnaire to assess and evaluate HRQoL outcomes measured in physical limitations, emotional stress, sexual activity, and social function from the date of device insertion to the time of data collection. Data were analyzed using the Statistical Package for Social Studies (SPSS 22; IBM Corp., New York, NY, USA). Results: Between February 2016 until June 2020, 26 patients were eligible for the study. The patients' support scores were moderate to high, indicating a positive effect on their HRQoL, with a mean score of 57.69 in emotional activity, a mean score of 34.07 in physical activity, and a mean score of 83.17 in social activity. The study's results show that the level of HRQoL varies among patients with VADs. Conclusion: Participating patients with VAD reported excellent health-related quality of life in all domains, with moderate to high support scores indicating a positive effect on their HRQoL. There is currently a lack of study on HRQoL in patients with VADs in Saudi Arabia. Therefore, this study may provide a baseline understanding of current challenges in the care of heart failure patients with VAD awaiting a heart transplant.

Background: Urinary tract infections (UTIs) are one of the most common bacterial infections during pregnancy, posing significant risks to maternal and perinatal health. Pregnant women are more susceptible to UTIs due to anatomical and physiological changes, including ureteral dilation and urinary stasis. Inadequate management can lead to complications such as pyelonephritis, preterm labor, and low birth weight. Understanding the risk factors and outcomes of UTIs is crucial for improving maternal and neonatal health, particularly in resource-limited settings like Bangladesh. Objective: To identify the risk factors of UTIs among pregnant women and assess their maternal and perinatal outcomes. Methodology: A case-control study was conducted at a tertiary medical college and hospital in Bangladesh from January 2022 to January 2023. Pregnant women aged 13–26 weeks with culture-positive UTIs were included as cases, and age-matched women with negative urine cultures served as controls. A total of 250 participants were enrolled. Data on socio-demographic variables, clinical symptoms, and pregnancy outcomes were collected using structured questionnaires. Statistical analyses were performed to explore associations between risk factors and UTI occurrence. Results: The prevalence of mid-trimester UTIs was 12.30%. The majority of cases (40.5%) were in the 20–30 age group. Escherichia coli (E. coli) was the most common causative organism, followed by Pseudomonas and Klebsiella. Risk factors included a history of UTI during the current pregnancy (22%) and increased sexual activity during early pregnancy (34.7%). Asymptomatic bacteriuria was the most frequent condition observed (32.3%). Maternal outcomes included a higher rate of caesarean delivery and preterm labor, while perinatal outcomes showed significantly lower birth weights in infants born to mothers with UTIs. Conclusion: UTIs in pregnancy are associated with significant maternal and perinatal risks, including preterm labor and low birth weight. Routine screening and early intervention can reduce complications. Efforts to improve awareness, prenatal care, and access to healthcare are essential for addressing UTIs in pregnant women, particularly in resource-limited settings.

Objectives: To analyze the clinical characteristics, management approaches, and outcomes of revascularization for symptomatic subclavian artery stenosis in 6 patients treated at the vascular surgery department of Moulay Ismail Military Hospital in Meknes between December 2021 and December 2024. Methods: A retrospective study was conducted on 6 patients who underwent percutaneous transluminal angioplasty (PTA) with or without stent placement. Clinical, radiological, and procedural data were collected and analyzed. Results: All patients had cardiovascular risk factors. Technical success was achieved in all patients with an average stenosis reduction of 87%. Complete symptom resolution was observed in 80% of patients. Minor complications, including hematoma at the puncture site, were reported in 1 case. Conclusion: PTA with or without stenting is a safe and effective treatment option for symptomatic subclavian artery stenosis, providing significant clinical improvement.

The increasing digitization of medical records and the concurrent rise in cyber threats pose significant challenges to the security and integrity of health data globally. This article reviews contemporary challenges and solutions for enhancing the protection of medical records against potential cyber-attacks and inadvertent breaches. It addresses the current vulnerabilities that exist within systems handling medical records, outlines advanced technological solutions such as encryption, blockchain, AI, and multi-factor authentication, and discusses comprehensive policy measures that include regular audits, privacy by design concepts, and training programs. The article also explores critical legal and ethical considerations, emphasizing the need to balance accessibility and privacy. Finally, it proposes long-term strategic approaches to foster innovation in healthcare cybersecurity. Through this comprehensive review, the article aims to delineate effective strategies for securing medical records in the age of cyber threats, contributing to the safeguarding of patient privacy and the trust integrity of healthcare systems.

Introduction: Thyroid hormone resistance (RTHβ) is a rare disorder characterized by reduced tissue responsiveness to thyroid hormones (THs). It is primarily caused by mutations in the thyroid hormone receptor beta (THRB) gene. This case describes a two-year-old boy diagnosed with RTHβ following the incidental detection of elevated thyroid hormones during a routine checkup. The clinical presentation, laboratory findings, genetic analysis, and implications for management are discussed, highlighting the complexities of this rare condition. Patient concern and Clinical Finding: A two-year-old boy was referred to the Pediatric Endocrinology Department due to elevated FT4 and FT3 levels with normal TSH identified in routine blood tests. Born at 36 weeks after an uneventful pregnancy to non-consanguineous parents, the child had normal growth and development until subtle symptoms, such as reduced physical activity, weight loss despite adequate nutrition, and warm, sweaty skin, were observed. Physical examination showed no goiter or ophthalmopathy, with neurological development appropriate for age and weight and height within normal percentiles. Laboratory tests revealed elevated thyroid hormone levels, negative thyroid antibodies, and normal thyroid ultrasound findings. Diagnosis/Intervention/Outcomes: The diagnosis of resistance to thyroid hormone beta (RTHβ) was confirmed through whole exome sequencing, which identified a heterozygous missense mutation in the THRB gene (c.1313G>A; p.R438H). This de novo mutation ruled out inheritance and suggested a sporadic origin. Regular monitoring of thyroid function tests and clinical follow-ups ensured biochemical stability and vigilance for potential symptoms of thyroid dysfunction. The child remained clinically euthyroid with normal growth and development, showing peripheral adaptation to altered thyroid hormone signaling. Long-term surveillance was recommended to monitor for any late-onset complications or thyroid-related symptoms, with an overall favorable prognosis. Conclusion: This case illustrates the complexities of diagnosing and managing RTHβ in a pediatric patient. The identification of a THRB mutation provided a definitive diagnosis and emphasized the utility of genetic testing. Long-term follow-up is essential to monitor the clinical course and adjust management as needed. Further studies are required to elucidate the genotype-phenotype correlations in RTHβ and optimize treatment strategies.

Retroperitoneal teratoma represents 1-11% of primary retroperitoneal tumors [1]. It is generally benign whether mature or immature. The treatment is surgical and the prognosis is excellent in the absence of complications. We report a case of mature retroperitoneal teratoma in an 8-year-old girl revealed by an isolated right paramedian abdominal mass. CT revealed a right suprarenal mass, fatty density with calcifications, without invasion of neighboring structures, measuring 124 mm in transverse diameter, 104 mm in anteroposterior diameter and 174 mm in height. Management consisted of complete excision of the tumor without incident.

Lung cancer is leading cause of mortality worldwide. About 80-85% of lung cancers are nonsmall cell lung carcinomas (NSCLC). The main subtypes of NSCLC are adenocarcinoma, squamous cell carcinoma and large cell carcinomas. These NSCLC are grouped together as their treatment and prognosis is often similar. Diagnosis depends on symptoms, histopathology and molecular biomarkers. Even treatment in late stages of NSCLC requires appropriate testing with predictive molecular biomarkers as it provides information that is essential for establishing appropriate treatment options for each patient. This review paper provides current molecular biomarkers in NSCLC which are useful in diagnosing as well predicting treatment.