Medicinal plant extracts with a therapeutic property has the tendency of wrong prescription and sometimes, overdosed. The fact that Xylopia aethiopica is a natural product does not automatically confer on its safety and might be risky to its consumers. Xylopia aethiopica fruit is known to have alkaloids, terpenoids, flavonoids, and organic oils. This study was carried out to assess the effect of ethanolic seed extract of Xylopia aethiopica on cadmium chloride induced toxicity on testicular tissues in adult male wisiar rat. Twenty (20) male albino wistar rats were used for this study- The animals were randomly divided into five groups with each containing four adults male wistar rats. The experiment lasted for 14 days. Group 1 received distilled water and feed, group 2 was treated with 2m°/body weight of Cadmium, group 3 was treated with 2mg/body weight of Cadmium plus 50mg body weight of ethanolic seed extract of Xylopia aethiopica, group 4 was treated with 2mg/body weight of Cadmium plus l00mg/body weight of ethanolic seed extract of Xylopia aethiopica, group 5 was treated with l00mg/ body weight of ethanolic seed extract of Xylopia aethiopica. After 14 days of administration, the rats were sacrificed and the testes harvested, processed and stained with hematoxylin and eosin (H&E) staining method. Blood samples were collected in EDTA bottles for hormonal analysis Histological findings from this study revealed that cadmium chloride have severe toxic effects on the histology of the testes. Some of the effects include; Sertoli cells degeneration seen along with spermatids, primary spermatocytes and secondary spermatocytes degeneration. There were also interstitial cellular lesions of Leydig cells. These results revealed that consumption of high dose of Xylopia aethiopica has ameliorative effect on cadmium chloride toxicity.