The ethical considerability of nonhuman animals remains a central debate in moral philosophy, often constrained by anthropocentric frameworks that prioritize human interests and rationality. Traditional ethical theories, particularly Kantian deontology and classical utilitarianism, have historically relegated animals to mere instrumental value, denying them intrinsic worth. This paper addresses a critical gap in value theory—the absence of a rigorous philosophical foundation for recognizing nonhuman animals as moral subjects in their own right. Employing the conceptual analysis method, this study critically examines the distinction between intrinsic/inherent and extrinsic value, exploring how a value-theoretic approach can redefine our ethical obligations toward animals. Drawing on the works of Tom Regan, Peter Singer, and Paul Taylor, the paper challenges speciesist assumptions and advocates for an ethical model that extends moral status beyond human boundaries. Through insights from environmental ethics, virtue ethics, and contemporary debates on sentience, this study highlights the philosophical and practical implications of acknowledging nonhuman animals as ends in themselves. The paper concludes that embracing a non-anthropocentric perspective in moral philosophy is essential for fostering a more inclusive and just ethical order.

Six Sigma has developed as a powerful methodology in industrial engineering for improving process efficiency, reducing defects, and enhancing overall productivity. Established in statistical analysis and continuous improvement principles, Six Sigma provides a structured framework for identifying process variations and reducing inefficiencies. This research paper explores the application of Six Sigma methodologies in industrial engineering, focusing on its impact on quality control, cost reduction, and operational excellence. The study examines real-world case studies from manufacturing industries, highlighting successful implementations of Six Sigma tools such as DMAIC (Define, Measure, Analyze, Improve, Control) and DMADV (Define, Measure, Analyze, Design, Verify). Additionally, it discusses the integration of Six Sigma with lean manufacturing principles to optimize workflows and reduce waste. The findings emphasize the significance of Six Sigma in fostering a culture of continuous improvement, driving competitive advantage, and ensuring sustainable growth in industrial engineering. This paper determines with recommendations for industries aiming to implement Six Sigma for long-term operational success.

Colorectal carcinoma is one of the most common cancers inspite of the improvement in treatment modalities, colorectal carcinoma remains as a leading cause of cancer mortality. In most of the individuals with colorectal carcinoma, cancer development is mainly due to complex interaction between the genetic factors and environmental factors Various prognostic factors have influenced the outcome of patient with colorectal carcinoma. In this study, immunohistochemical expression of Her2/neu marker is correlated to various clinicopathological variables like age, gender, tumor size, grade, stage of the tumor.

Background: Abruptio placenta is a major cause of massive obstetric hemorrhage and significant cause of maternal and neonatal morbidity and mortality worldwide and in developing countries including India. This study aimed to determine risk factors for abruptio placenta and subsequent feto-maternal outcome at a tertiary care center (hospital). Methods: A prospective study was conducted at department of obstetrics and gynaecology, RIMS Adilabad. All patients diagnosed with abruptio placenta clinically and/or sonographically were included in the study. The maternal complications and fetal outcome were analyzed in detail. Results: In this study, 82 women were diagnosed with abruption placenta. Incidence of abruptio placenta is 1.4% at our institute. Most patients in our study are multiparous (64.6%), un booked (31.7%) and are in the age group of 20-30 years (58.5%). In our study abruption placenta was mostly associated with PIH/Hypertensive disorders of pregnancy (56.09%). H/o abruption placenta in previous pregnancy (12.19%), Idiopathic (23.17%), Trauma (2.4%), PROM (2.4%) are other risk factors associated with abruptio placenta. Anemia is associated with 58% of cases. Majority (54.8%) of cases delivered vaginally, 45.12% patients were delivered by LSCS. 63.14% babies were live born, 23.17% were IUD, 13.4% were stillborn. Post partum hemorrhage (19.5%), Acute renal failure (17.7%), disseminated intravascular coagulation (15.8%) are important maternal complications. Maternal mortality rate is 2.4%. Perinatal mortality is 25.6%. Conclusion: Abruption placenta is associated with poor maternal and fetal outcome. There is need to spread awareness regarding taking adequate antenatal care so that associated risk factors could be diagnosed early and treated adequately. Prompt resuscitative measures and expedition of delivery process after abruption favours good fetomaternal outcome.

This study successfully synthesized SnO2 nanoparticles via co-precipitation and subsequently loaded them with varying weight percentages (1-4%) of graphene oxide (GO) using a hydrothermal method. The resulting GO/SnO2 nanocomposites were comprehensively characterized using a suite of spectroscopic techniques, including SEM, TEM, XRD, elemental mapping, EDX, FT-IR, BET, PL, UV-Vis, and DRS. These analyses confirmed the successful formation of the desired nanostructures. Furthermore, the photocatalytic performance of the nanocomposites and pure SnO2 was evaluated by monitoring the photodegradation of methylene blue under visible light irradiation, demonstrating the impact of GO loading on photocatalytic activity. The degradation efficiencies of the GO/SnO2 were much higher than that of pure SnO2. From the results obtained, we believe that this current study will provide relevant views for further fabrication of other novel nanostructures and exploration of their potential carcinogenic and environmental consequences.

Background: Adolescence is a critical transitional phase marked by developmental and social changes, often accompanied by behavioral challenges. Aggressive behavior during this period poses significant risks, including academic failure, social maladjustment, and long-term negative behavioral patterns. The study aimed to assess the risk factors which are associated with aggressive behavior among adolescents in Bangladesh. Methods: A cross-sectional study was conducted among 103 adolescents from Shahid Abdur Rab Serniabat Government Secondary School, Rupatoli, Barishal, using a convenient sampling technique. Data collection involved a self-reported questionnaire comprising two sections: 1) Demographic Information and 2) the Buss-Perry Aggression Questionnaire (BPAQ). Statistical analyses, including descriptive and inferential statistics, were performed using SPSS 25. Results: The mean aggression score among adolescents was (M = 2.70, SD = 0.62), reflecting average levels of aggression. Significant relationships were found between monthly family income (r = 0.19, p = 0.04) and the number of siblings (r = -0.62, p = 0.04) and aggressive behavior. Adolescents from families with higher monthly incomes exhibited higher aggression scores, whereas those with a greater number of siblings demonstrated lower aggression scores. Conclusion: The findings of this study provide insights into the risk factors associated with aggressive behavior among adolescents. These results can inform the development of targeted strategies to mitigate behavioral problems and support health education initiatives aimed at addressing the impact of aggression in this vulnerable age group.

The purpose of this paper is to analyze the emergence process or a new paradigm in the theory and practice of knowledge management. It is the paradigm of artificial knowledge. This new paradigm changes the semantic spectrum of the concept of knowledge as it has been used so far in knowledge management systems. Artificial knowledge is completely differentiated from human knowledge and can no longer be considered a justified true belief. Artificial knowledge is a product of artificial intelligence technology. The paper performs a semantic analysis of the new concept and its features by comparison with human knowledge. Also, the paper presents a bibliometric analysis of the most significant publications discussing artificial knowledge and artificial intelligence. The bibliometric analysis is done using VOS viewer, a specialized software program for such research. The present paper shows that researchers in knowledge management face the emergence of a new paradigm.

In the credit system, academic advising has become an essential factor for student success in universities. It is a student-centered initiative that promotes student engagement in the institution by supporting students in their academic and career goals. This study presents a comprehensive and effective academic advising model for Information Technology students, combining the traditional role of academic advisors with advanced technologies such as artificial intelligence and machine learning. The proposed model integrates virtual assistants to answer training regulations and curriculum questions, personalizes learning paths, and automatically recommends courses based on real-world data. The pilot study results on 100 IT students from second to four years show that the system significantly improves their access to information, learning resources, and satisfaction. This study marks a significant step forward in the application of AI in higher education, opening the potential to improve learning efficiency and training management on a large scale.

Background: HELLP Syndrome is the severe form of preeclampsia characterised by hemolysis(H), elevated liver enzymes (EL) and low platlets count, frequently leads to adverse maternal and perinatal outcome. This study aimed to determine the incidence, complications of HELLP syndrome and evalution of Maternal and Fetal outcome at a rural tertiary care center. Methods: A prospective observational study was conducted at Department of obstetrics and gynaecology, RIMS, Adilabad during a period of one year. The analysis of data was done on all the patients diagnosed with HELLP syndrome and categorized by mississippi classification for better analysis of complications and outcome in HELLP syndrome. Results: Total 5820 women were delivered in our institute during the study period of which 572 women with Pre-eclampsia and 48 patients diagnosed with HELLP syndrome. Incidence of HELLP syndrome is 0.8 % of total deliveries and 8.3%of Pre-eclampsia patients. Most of them were primigravida 52%. Majority were in 32-36 weeks of gestational age Out of total 48 patients of HELLP syndrome,40 patients delivered vaginally and 8 patients delivered by LSCS Complications includes Ascites (27%), Postpartum hemorrhage (25%), Placental abruption (23%), Acute renal failure (16%), Pulmonary edema (10.4%), Disseminated intravascular coagulation (6.2%), Multi Organ Dysfunction (4.1%). Patients who received Blood products were 54.1% Preterm deliveries (58.3%), NICU admission (27%). Intra uterine Fetal demise (14.5%) There was no maternal mortality. Perinatal mortality rate was 43.7%. Conclusions: Vaginal delivery is allowed as better stabilization and better maternal outcome. There is increased fetal morbidity and mortality as patients came in advanced disease. Early detection and management of its complications with timely intervention to arrest further progress to reduce maternal and neonatal morbidity and mortality.

Background: Sickle cell disease (SCD) impacts the physical, emotional and psychological aspects of life of the affected persons, often times exposing them to disease-associated stigmatization from family members and/or the community and this in turn affects their health-related quality of life (HRQoL). There is paucity of data from southern Nigeria as regards stigmatization among SCD patients, hence this study was aimed at determining the level of stigmatization amongst them. Methodology: It was a cross-sectional study involving two hundred and twenty-four SCD patients recruited from three well recognized health facilities that offer comprehensive care for individuals with SCD in Benin City, Nigeria. The measure of sickle cell stigma and the sickle cell disease health-related stigma scale psychometric tools were used for this study. Results: One hundred and sixty- four (73.2%) participants were not married despite attaining marriageable age. One hundred and seventy-one (76.1%) were dependents, living with their friends and family members. Sixty-eight (47.7%) had a severe disease course and one hundred and eighty-five (82.6%) had perceived/ experienced stigmatization. Conclusion: The study found a high prevalence of stigmatization among SCD patients.

Digestive haemorrhage (HD) is a frequent reason for consultation at the Emergency Department. Approximately 80% of GI haemorrhages are upper GI, i.e. related to a lesion located above the angle of Treitz. The main causes are ulcer disease, portal hypertension, gastritis and ulcerated lesions of the stomach, and reflux oesophagitis. In approximately 10% of cases, a rarer cause (Mallory-Weiss, acquired vascular malformations, Dieulafoy, primary PAEF or secondary aortodigestive fistulas, biliary or pancreatic tract anomalies, tumours,...) is responsible. We report the case of a patient with high HD in whom aortoduodenal fistula was the cause diagnosed on abdominal CT.

Background: Breast cancer is a significant global health concern, with its incidence steadily rising in both developed and developing nations. It is the leading cause of cancer-related deaths among women, accounting for 16% of cancer fatalities in adult females. This study aimed to assess the level of breast cancer knowledge among nurses working at a tertiary-level hospital in Barishal. Methodology: A cross-sectional study was conducted among 266 nurses at Sher-E-Bangla Medical College Hospital, Barishal. A convenient sampling technique was applied, and data were collected using a self-structured questionnaire developed through an extensive literature review. Data analysis was performed using SPSS-23, employing both descriptive and inferential statistics. Results: Nearly 97% of nurses recognized breast cancer as a life-threatening disease, while more than half (61%) disagreed with the notion that breast cancer is preventable. The overall mean knowledge score on breast cancer was 3.75 (SD = 0.40), indicating an average to moderate level of knowledge. Marital status (t = -2.84, p<0.05) was found to have a statistically significant association with breast cancer knowledge, with married nurses demonstrating higher awareness than their single counterparts. Additionally, significant differences in knowledge levels were observed between Muslim and non-Muslim nurses, with non-Muslim nurses exhibiting greater awareness of breast cancer. Conclusion: The findings of this study provide valuable insights into the level of breast cancer knowledge among nurses at a tertiary-level hospital in Barishal. The results can serve as a guide for improving nurses' understanding of breast cancer and developing strategies to reduce associated risks. Furthermore, these findings emphasize the need for health education programs aimed at raising awareness and disseminating crucial information on breast cancer prevention and early detection.

A coral-pink gingiva reflects the normal health of blood vessels and the proper width of keratinized tissues, both of which are essential for dental and facial aesthetics. Gingival pigmentation is caused by melanin granules and manifesting as uneven brown, light brown, or deep purplish discoloration and may necessitate cosmetic therapy. Among the various treatment modalities, diode laser and bur ablation are commonly used for gingival depigmentation. Moreover, platelet-rich plasma (PRP), which delivers a supra-physiological dose of growth factors, has emerged as a promising adjunct to accelerate wound healing in periodontal aesthetic procedures. This article presents two case reports of two female patients with gingival pigmentation, who were treated at King Abdullah Medical City Specialist Hospital using a split-mouth approach. In one patient, diode laser ablation was performed on the lower anterior gingiva and bur ablation on the upper anterior region; in the other, laser and bur ablation were applied in different quadrants. Immediately after ablation, injectable PRP was administered into the depigmented areas. Healing was evaluated using the Healing Index on days one, three, seven, 14, and 30, and pigmentation was assessed preoperatively and on day 30 with the Dummett-Gupta Oral Pigmentation Index. The results of the two case reports suggest that adjunctive PRP may enhance wound healing following gingival depigmentation, necessitating further clinical trials with standardized protocols and larger sample sizes.

Organizational culture is an important element for a company. Habits are created because of the communication that occurs between employees. Every employee should have the motivation to work. However, in reality, quite a few employees lose direction when doing their work. Therefore, the problem in this research is whether organizational culture and work motivation influence employee performance, either partially or simultaneously. This research aims to analyze the influence of organizational culture and work motivation on employee performance at NCTA partially and simultaneously. The population in this study were all NCTA employees, especially the general bureau, while the sample was obtained using the Slovin formula, 63 people. The data analysis method used is the descriptive percentage analysis method, multiple linear regression analysis method with partial test hypothesis testing (t), simultaneous test (F), and coefficient of determination. The conclusion obtained is that organizational culture and work motivation have a partial positive and significant influence on employee performance. Simultaneously, it can also be concluded that organizational culture and work motivation have a positive and significant influence on employee performance. This research also states that organizational culture and work motivation influence employee performance simultaneously by 52.3%.

The Covid-19 pandemic has caused some manufacturing companies to experience a decline in company value. The decline in company value occurs due to various factors. Factors that are thought to affect company value include profitability, liquidity, solvency and dividend policy. This study aims to determine the effect of profitability, liquidity and solvency on company value with dividend policy as a mediating variable. The population and sample in this study are manufacturing companies listed on the Indonesia Stock Exchange during the 2019-2022 period. The research design used is quantitative research. The data used are secondary data obtained through the IDX website and the websites of each company. The data analysis used is descriptive statistical analysis, classical assumption testing and multiple regression analysis.