Phytomedicines are becoming more popular in the world for their ability to cure diseases with less toxicity and better therapeutic efficacy. Herbal medicines may also have disadvantages of poor bioavailability, toxicity, stability issues and patient compliance. In order to minimize these problems various drug delivery systems such as liposomes, phytosomes, niosomes, ethosomes and trasferosomes etc are being developed for phytomedicines. Novel drug delivery systems can improve bioavailability of drug that refers to the existence of drugs in the body part where they are actually needed. Ethosomes are noninvasive flexible vesicular carriers that enable the drugs to permeate through the deeper layers of skin and systemic circulation. They are mainly composed of phospholipids, high concentration of ethanol and water. As ethanol is known for its disturbance of skin lipid bilayer arrangement; therefore, inclusion of ethanol into a vesicular membrane provides the ability of vesicle to permeate through the stratum corneum. The high flexibility of ethosomal carrier from the added ethanol allows the elastic carrier to squeeze through the skin pores. Herbal ethosomal formulation has been effectively used to enhance bioavailability of many herbs including Glycyrrhiza glabra, Sophora alopercuroides, Cannabis sativa, Sesbania grandiflora and Podophyllum hexandrum

A total number of 1042 flathead mullet Mugil cephalus were searched for parasites during summer & autumn 2015 and winter & spring 2016. Six different parasite taxa belonging to Microsporidia, Myxozoa, Ciliophora, Anisakidae and Gnathostomatidae were identified. The total number of infested mullets along the study period with one or more parasites was 396 representing a percentage of 38.0%. Mullets were infested with Microsporum velveticum through ingesting the intermediate host. This parasite was observed in the intestinal epithelia, adipose tissue, liver, stomach epithelia, muscles and air bladder. Myxidium depressum was observed in the liver and gall bladder of infested mullets in a plasmid stage that had undergone sporogony forming multicellular myxospores. Trichodina murmanica was observed on the gill surface, the operculum and respiratory epithelium where superficial to deep ulcerative lesions were visible. Third Larval stages of Anisakis simplex, Raphidascaris acus and Gnathostoma spinigerum were observed free in the duodenum and ileim or encapsulated in the stomach epithelia, liver, and muscles. The infra-community of protists was highest in winter and fall while for parasitic nematodes was during spring and summer. Seasonal fluctuation of the parasite community was demonstrated by using standard calculations.

This is a cross sectional study of 60 patients with organophosphorus poisoning admitted at MGM Medical College and Maharaja Yashwantrao hospital Indore from June 2013 to May 2014. Severity of poisoning and requirement of ventilator support were studied in these patients. The POP scale and pseudo cholinesterase levels both showed a significant association in predicting the need for ventilatory support. Lower grade of poisoning had a better outcome whereas higher severity of poisoning had a poorer outcome

This cross-sectional study was conducted to determine the level of violence and influencing factors, reasons for violence according to women, women‟ behaviors in response to violence, reasons given by women who are exposed to violence for sustaining their marriage in Sanliurfa in Turkey between 15 December 2013 and 15 February 2014.Participants were selected by using 30 cluster sampling methods. A total of 300 married women were reached. The prevalence of being exposed to any type of violence was determined 78.7%; this included physical violence 18.3%, verbal violence 50.3%, emotional violence 38.3%, sexual violence 8.0%, and economic violence 57.0%. Considering all types of violence, the most common applicator of violence was husband (90–100%). Almost half of the women stated that they gave no reaction/became introverted and cried in response to violence from their husbands. Almost half of women being exposed to violence by their husbands were observed to sustain their marriage. It is also, 23.6% of women stated that they confirmed man's wife to violence in some cases (It is also 23.6% of women stated that they are OK with their husbans violance to themselves in some cases.) Women who participated in the study had a very high prevalence of being exposed to violence. Even more, violence was approved by women in some cases. These results show that health care professionals rendering services in the region have great responsibilities to prevent, determine and protect individuals from the violence, as well providing treatment and rehabilitation.

Patients with multiple myeloma may present a variety of renal manifestations as a result of damage from circulating light chain immunoglobulin components. The renal alterations can interest any of the renal compartments, and in certain cases more than one compartment can be affected. The resulting high serum concentrations of these proteins often lead to tubular interstitial injuries as endocytic receptors in the proximal tubules are overwhelmed. A 46-year-old white man with a history of left hip pain was diagnosed as multiple myeloma. Imaging including MRI and PET scan showed a left pelvic heterogenous mass causing bone destruction and compressing the adjacent organs. He was referred to the nephrology department due to the onset of acute kidney injury requiring hemodialysis. A kidney biopsy was performed and showed patterns of acute interstitial nephritis and focal linear staining for kappa light chains along tubular basement membranes on immunofluorescence. After glucocorticoids for acute interstitial nephritis and chemotherapy (Bortezomib -Cyclophosphamide - Dexamethasone) directed against the clone, the renal function partially improved and the patient got off hemodialysis support. Conclusion: Acute kidney injury may be the first clinical presentation in patients with multiple myeloma. Could interstitial nephritis be the only manifestation of MM without myeloma cast nephropathy and whether it was glucocorticoid or chemotherapy directed against the clone that has resulted in a significant improvement in renal function.

Urinary tract infection (UTI) is one of the most common infectious diseases globally. An increasing antimicrobial resistance among Community-acquired (CA) and Nosocomial UTI has been rapidly growing. Cross-sectional, analytical and descriptive study was conducted to investigate the current in vitro susceptibility pattern of the clinically isolated bacteria among Community and Hospital-acquired (HA) UTI. Patient data for 421 urine specimens were collected from the case records during October 2016 to March 2017. Significant growth was yielded from 170 of urine specimens. Kirby-Bauer disk diffusion method was used for detection antibiotic susceptibility pattern for all isolates. Of the total 170 (40.4%) culture positive samples, 51.2% and 48.8% were CA and HA UTI respectively. The culture positivity of UTI among the female was (44.1%) compared to (55.9%) among the male. There was a significant difference in resistance pattern between CA and Nosocomial UTI. The distribution of the isolated pathogens were (51.2%) and (48.8%) in CA and HA respectively. The predominant bacterial isolate was Escherichia coli (43.5%) in both cases of community and nosocomial UTI. However, Klebsiella pneumoniae (69.0%) was mostly isolated from HA-UTI while Staphylococcus aureus (80.0%) was mostly detected in CA-UTI. The recent study revealed high resistant rates of UTI among HA as compared to CA. This study revealed that more than 90% of HA-UTIs isolated pathogens were resistant to broad-spectrum Penicillins, Cephalosporins, Quinolones, and Macrolides. Contrarily, high rates of bacterial sensitivity was found towards Imipenem (82.9%), Nitrofurantoin (72.4%), Ertapenem (70.7%), and Amikacin (67.1%). Even if Escherichia coli remains the major pathogen in UTI, the resistance pattern of CA-UTI is frightening in our country. Nitrofurantoin is the only oral drug that retained reasonable activity against most UTI pathogens. Imipenem and Ertapenem remain effective for UTI bacterial isolates. The changing of UTI etiological agents was observed in the current study.

This paper discussed on small and medium scale industries pathway to Nigeria economic development. It also point out the problems facing the entrepreneurship development of Nigeria economy. It also examines the importance of entrepreneurship in Nigeria. The methodology adopted was systematic review method. It also found that entrepreneurship can enhance economic development in Nigeria primarily by generating employment opportunity. The study also revealed that initiatives by government failed because of over bearing bureaucracies, corruption, inadequate and inefficient infrastructure facilities, financial backup and maladministration. The paper also recommended that government and banks should recognize the important entrepreneurship to her economic development growth by providing the enabling environment for small and medium scale industry to develop. Specifically, government should provide infrastructural facilities (electricity, road network, and communication). It is also recommended that government should reactivate all the institutions established to promote small and medium scale industries in Nigeria.

In the work, modeling of the forming process for aluminum detail was carried out. As a detail, "Pen" is chosen for which the material AK6M2 is determined, taking into account its physico-chemical properties. In the beginning, a 3D detail model is constructed, using the SolidWorks program. Then in the program Nova Flow, entire process of filling the mold in real time, rate of filling the mold cavity with metal, hardening time of the casting was determined. The temperature change dynamics of the casting after filling the mold is investigated. Possible nodes are susceptible to formation of shrinkage shells.

The rupture of the calcaneal tendon is a frequent lesion requiring surgical management. For chronic disruption in particular, restorative surgery is desirable and several methods have been described. We report a retrospective study of eight cases of chronic rupture of the calcaneal tendon treated surgically by myotendinousplasty in V-Y according to Abraham, collected in the Traumatology and Orthopedics II department of the Mohammed V Military Teaching Hospital in Rabat Morocco between 2010 and 2015. The majority of patients were male. The cause of chronic rupture of the calcaneal tendon was a diagnostic error in 25% of the cases, a lack of knowledge of the pathology in 62.5% of the cases and negligence in 12.5% of the cases. The results were evaluated according to the Kitaoka score after an average follow-up of three years. They were very satisfied with a score of 89%. The aim of this study is to highlight the difficulty of making the diagnosis in certain circumstances, which is the cause of chronic rupture and to underline the interest of the surgical treatment, by the myotendinousplasty "V-Y" in this case

The friendly relations between China and Pakistan were set up in May 1951.The friendship of China and Pakistan is all weather and everlasting. The relationship is more profound than the seas and higher than the mountains. The supporting relations of China and Pakistan have turned into a model for a well disposed concurrence of creating neighboring nations. China and Pakistan are getting a charge out of solid respective social, financial and military connection. Both of the nations are endeavoring together to promote peace, steadiness and monetary flourishing in Asia.

This study was carried out to investigate the prevalence profile of cutaneous adverse drug reactions (CADRs) on in patients at Tongji hospital. A retrospective study was carried out on in-patients at Tongji medical college, Huazhong university of Science and Technology from May 1985 to April 2012. Out of 110553 in-patients 777 cases were diagnosed as CADRs. The most common type of CADRs was maculopapular eruption followed by Erythema multiforme, Fixed drug eruption and urticaria. The most common drugs causing CADRs was antibiotics followed by antiepileptic drugs, antipyretics and analgesics. The most common type of CADRs was maculopapular eruptions followed by erythema multiforme, fixed drug eruption and urticaria. The main offending drug was antibiotics followed by antiepileptic drugs, antipyretics and analgesics

Hepatitis C Virus (HCV) educational interventions are one option for helping these patients adhere to treatment recommendations while improving their quality of life. The aim of this study is to determine the effect of health-related quality of life educational interventions on Chronic Hepatitis C Patients'. A quasi-experimental study design. This study was conducted at the liver outpatient clinic of Fayoum Medical University Hospital. A purposive sample of hundred fifty patients was included. Tools: 1) Patients' needs assessment questionnaire. 2) Health-Related Quality of life of Chronic liver disease questionnaire (CLDQ).

The present study was carried out to evaluate the protective role of aqueous extract of Mentha spicata (MSE) leaf on dichlorvos (DDVP) induced oxidative stress in rat brain. Male rats were divided into 4 groups, the first group served as control (C). Group (E1) received 5.33mg/Kg BW of DDVP and group (E2) received 5.33mg/Kg BW of DDVP with MSE (100.0 mg/kg) and the group (E3) received MSE (100.0 mg/kg). Rats under all the groups were treated with their respective constituents for 30 days. The results suggested that rats under E1 suffered from significant (p<0.01) decline in the activity of superoxide dismutase, catalase, glutathione peroxidase with a significant elevation in the levels of malondialdehyde of their brain. Histological changes were also found to be prominent in the brain of E1 group as compared to others. Rats under E2 showed recuperation tendencies which were evidenced by partial restoration of antioxidant enzyme activity and the lesser degree of damage in histological aspect as compared to E1. No significant changes were observed in either biochemical constituents or histological aspects of rats under E3. The current study suggests that DDVP can cause oxidative damage and brain injury in male rats and co-administration of MSE with the selected dose partially attenuates the toxic effect caused by DDVP

This research is undertaken at the Secondary Level of Bangladesh Open University (BOU). It attempts to present the frequency of Code-switching and students‟ perception towards it and their functions in facilitating EFL learning. Using questionnaires as a method of data collection, the findings reveal that instructors frequently code-switched between Bangla and English. This phenomena was related to both teachers‟ and students‟ language competence. Students exhibit positive perceptions towards it as a learning tool. Analyses of data reveal that Code-switching helps students to learn their lessons. Moreover, the students are welcoming codeswitching very much.

The goal of our retrospective observational study is to look for the EEG changes in different location of ICH and to identify electrographic seizures. The current study brings into attention that seizures are frequent complication of intracerebral hemorrhage and may be a target for improving ultimate outcome. They occur in both lobar and deep hemorrhage and with or without associated intra ventricular extension. The study calls for need of prospective study to correlate the electrographic abnormalities with location of bleed and also the usage of prophylactic antiepileptic drugs in patients