The main purpose of this research is to find out the relationship between capital structure (debt-equity) as and Profitability of the listed cement companies in Pakistan Stock Exchange. Further specific objective is to find out relation of debt equity with gross profit, earning per share, and return on capital and return on equity. The sample is taken from 10 cement companies which are listed on Pakistan stock exchange. The secondary data is taken from 2011 to 2018 (i.e. 8 years). Mean and standard deviation of all ratios and Pearson product correlation analysis is performed with the help of Eviews 9 to find the relationship between capital structure and profitability. This research determines that debt / equity (Capital Structure) is adversely linked with the profitability, it suggests that decrease in the profitability of the organizations is due to increase in debt capital & vice versa.

Introduction: Alcoholic cirrhosis is the end spectrum of alcoholic liver disease (ALD), which includes fatty liver or simple steatosis, alcoholic hepatitis, fibrosis, cirrhosis and super-imposed hepatocellular carcinoma. Although several studies have been conducted on dyslipidemia in cirrhotics in developed countries, there is a paucity of data in this regard in India. As there is a high prevalence of chronic liver disease in our country, we conducted this study to determine lipid levels in patients with cirrhosis and to assess if it relates to the severity of cirrhosis according to pughcriteria. Materials and methods: This is a cross sectional case-control study conducted on alcoholic cirrhotic patients and 50 healthy individuals (controls) without history of alcohol consumption. All the cases were investigated for fasting lipid profile and ultrasonographic evidence of cirrhosis. Biochemical tests including liver function tests were performed, which assisted in the diagnosis of alcoholic cirrhosis. These include serum bilirubin, total serum protein, serum albumin, serum globulin, aspartateaminotranferase (AST), alanineaminotransferase (ALT) and alkaline phosphatase (ALP). The data was collected systematically and analysed statistically according to the standard statistical methods. Results: Serum total, LDL, HDL, VLDL, cholesterol and trigylceride level in patients with cirrhosis is inversely correlate with severity of cirrhosis

The transformation of the Ministry of Defense's budget policy, the Indonesian National Armed Forces Headquarters and three other departments (Army Headquarters, Navy Headquarters and Air Force Headquarters) from the money follow function to money follow approach requires the implementation and development of holistic financial planning, budgeting and management information systems. thematic and integrative. The pattern of relationships between variables concerning human resources in organizations, such as user participation, user satisfaction, user perceptions of task complexity, perceptions of system complexity and perceptions of system performance determine the effectiveness and efficiency of information systems. This study aims to find out what the overall level of compatibility of the model explains the direct and indirect relationship between participation, task complexity, system complexity, satisfaction with performance. Using a single cross-sectional survey design, data collection through face-to-face interviews with 209 information system users with a questionnaire as the main data collection tool and data analysis applying the structural equation model (Structural Equation Model) with the help of LISREL 8.5 software, this study concluded that there were compatibility of the whole model, measurement model and structural model hypothesized by research with data obtained from research (survey).

The damage caused by the lupus nephritis to the patient's kidney was very little studied for treatment module; however, we have the understanding the disease involving in the kidneys by an immune complex glomerulonephritis. Human genomics have been decoded since 2004, it should give clinical scientists and medical doctors a new scenery to develop some new treatment modules to cure these kinds of patients. Here we used a group of genomic data from lupus nephritis to combine the modern medicine knowledge and Traditional Chinese Medicine (TCM) so that an integration module will be subject to the clinical field. The integration model is primarily relied on a comprehensive regulation mechanism of system biology including network, topology and gene-drug interaction database. In this manual we first study the role using genomic expression signature from several databases of clinical lupus nephritis, and then we combine current medications with their immune suppress treatment and TCM with their theory and medication in order that the integration model was eventually established. In near future, we will extend a second-generation model based on the module by using a set of clinical genomic data from different patients such as individual patient genomic data, each patient symptom, laboratory results.

The incidence of breast cancer is increasing throughout the world as well as in India. Many risk factors and prognostic factors of breast cancer have been identified but the associations between mast cell infiltration and the clinical features of breast cancer remain unclear. The aim of the study was to estimate the mast cells number in malignant tumors and axillary lymph node and to find out any correlation between the number of mast cells and hormone receptor status. An institution based descriptive study was done in a tertiary care hospital. Total 44 specimens of post operative breast tissue with malignant breast lesion & dissected axillary lymph nodes were taken. Counting of mast cells was done in Toluidine blue stain. Immunohistochemical staining was done for ER, PR & HER2/neu using immunostaining kit. It was observed that when the tumor grade increases the number of must cell decreased per high power field. The mast cell count was significantly higher in cases of ER positive and PR positive breast cancers than that of the ER negative and PR negative respectively but there was no significant relation between mast cell count of HER2/neu. Mean mast cell count of triple negative cases was significantly low. This study indicated that the number of mast cells in breast cancer was inversely correlated with the grade of this tumor and higher mast cell count was related to good prognosis.

Organophosphorus compounds are organic compounds containing phosphorus. They are used primarily in pest control as an alternative to chlorinated hydrocarbons that persist in the environment. Some organophosphorus compounds are highly effective insecticides, although some are extremely toxic to man, including sarin and VX nerve agents. To study the myocardial involvement in organophosphorus compound poisoning. Patients got admitted to the department of medicine, Adichunchanagiri institute of medical sciences, with history of organophosphorus compound poisoning during the period of January 2016 to December 2016. In the preset study, the incidence of OP compound poisoning common in males compared to females. Majority of patients were in the age group 31-49 years. The most common clinical finding in patients was tachycardia (36%) followed by bradycardia (32%). Hypertension was seen in 5 (20%) patients and 4 (16%) showed hypotension. Most common ECG finding was ST elevation (48%), Sinus tachycardia (24%) and QT prolongation (16%) and sinus bradycardia (12%). 15 (60%) of the patient had a significant levels of serum Acetylcholinesterase level >2500 IU/L. Cardiovascular effects are quite common following acute OP poisoning. These effects pertain to different muscarinic and nicotinic effects on the heart, electrolyte disturbances, ABG disorders, respiratory failure and over-atropinization.

Coronoid process is a triangular plate of bone seen in the upper part of ramus of the mandible. It shows variations in the shape due to the differences in the attachment of two important muscles of mastication- masseter and temporalis. The changes in the shape helps in identification of race and to surgeons during operative procedures. The aim of the present study is to observe the changes in the shape and to compare with other studies. 121 sides of the mandibles were studied and the results were represented graphically. A unique quadrilateral shape of the coronoid process was detected for a mandible unilaterally. The most common shape was triangular (43.80%) followed by rounded (38.84%) and hooked (16.52%) in that order. The values correlated with other studies on comparison as p value calculated was significant statistically.

Background: Approximately 1–2% of the adult population in developed countries has Heart Failure, with the prevalence rising to ≥10% among persons 70 years or more. Most of the molecular and cellular mechanisms responsible for the cardiovascular effects of thyroid hormone have been clarified. Thyroid hormones produce changes in cardiac inotropism and chronotropism more rapidly than would be expected from regulation of gene expression. Hypothyroidism causes cardiac atrophy, due to decreased αMHC expression and increased β MHC expression. Moreover, hypothyroidism also leads to chamber dilatation and impaired myocardial blood flow [1]. Material and Methods: 200 patients between age group of 45 to 75 yrs, presented in medical emergency and medical outdoor of the institution with heart failure were studied. Comparison of Thyroid Profile and LVIDd (Left Ventricular Internal Diameter at Diastole) was done at Baseline, 3 months and 6 months. Results: After comparing the thyroid profile and 2DEchocardiography findings in subclinical hypothyroidism of treated group after 6 months, there was increase in TSH and fall in FT4 (p 0.001) with a significant improvement in LVIDd. Conclusion: There was improvement in EF, a decrease in LVIDd, increase in Mitral E velocity, decrease in Mitral A velocity and increase in E/A ratio in cases as compared to controls with treatment

In globalization era, most of children are easier to be interfered with the facilities provided by the development of era. It influences students thought, behavior, and character that can cause the development of emotional. As parent must be more sensitive to give children parenting for their emotionals, to guide and teach toward something proper and belong before they go down into worse behavior as the result of lost control of emotional. This research is aimed to find the way how to do parenting properly toward the children based on Islam perspective. The method of research used is done by Library Research in term of related and relevant books toward the existed case in this research. The result of this research shows that emotional parenting is quitely important and there are four important phases of children life related with their emotional characteristics. Moreover, in every single phase has own parenting method to be implemented.

Generally speaking, listening, speaking, reading and writing are four basic skills for English learners. Reading as a mean to learn English is indispensable in the process of English learning. Thus, English reading comprehension is especially important for English learners. However, grammatical metaphor in reading materials is always one of the reasons that cause troubles for English learners. Because of grammatical metaphors students may miss or misunderstand some important information in English reading materials. Thus, it is essential to conduct a deep research on grammatical metaphors. And this article will explore how interpersonal metaphors influence students’ English reading comprehension. This article will explore this kind of influence from two aspects: one is the Mood metaphors; the other is the Modality metaphors. In addition, some cases will be listed to support the ideas. Meanwhile, some feasible suggestions on English reading comprehension will be put forward

Hospital assessment and performance are crucial measures to evaluate the efficacy of any health Centre and it requires a thorough knowledge about the same. A retrospective evaluation from 1st Aug 2018 to 30th Aug 2018 of the tertiary hospital were assessed for Bed Occupancy Rate, Bed Turnover Ratio , Average Length of Stay, Mortality rate for ICUs, Mortality rate for hospital and were subjected to mathematical formula to calculate and interpret the results. This manuscript provides the case study and a mini review on the same. Comprehensive assessment of hospital enables the identification of strengths and weaknesses in the system that can be used to develop new improving strategies.

Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. Symptoms typically begin three to fourteen days after infection. This may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin rash. Recovery generally takes two to seven days. The present study was conducted in Department of Medicine, Adichunchanagiri Institute of Medical Sciences, from the period of January 2017 to December 2018 to Study of Clinical and Haematological profile of patients with dengue fever. In our study, the incidence of dengue fever common in males compared to females. Majority of patients were in the age group 31-40 years. Out of 100 patients 69(69%) patients were diagnosed to have DF, 24(24%) patients were diagnosed to have DHF and 7(7%) patients were diagnosed to have DSS based on WHO criteria. Fever was present in100 cases, myalgia in 94 cases, headache was present in 81 cases, joint pains in 90cases, vomiting in 74 cases, pain abdomen in 69 cases, rash in 52 cases, hepatomegaly in 21 cases, bleeding in 34 cases and shock in9 cases. As per WHO criteria 71(71%) patients had low platelet counts. Apart from attempts to control the spread of the Aedes mosquito there are ongoing efforts to develop antiviral drugs that would be used to treat attacks of dengue fever and prevent severe complications. Discovery of the structure of the viral proteins may aid the development of effective drugs

Background: Children with ß-thalassemia major are at higher risk for myocardial dysfunction that adversely affects their quality of life. Cardiac biomarkers are valuable tool for assessment of such children. Our aim was to assess heart fatty acid-binding protein (H-FABP) versus B-type natriuretic peptide (BNP) in thalassemia patients as biomarkers of myocardial dysfunction. Methods: This controlled study involved 35 children with ß-thalassemia major and 35 healthy children. Clinical assessment, echocardiography, serum ferritin, BNP and H-FABP were done. Results: H-FABP and BNP were higher in thalassemia than healthy children. Left ventricular dimension and pulmonary pressure were significantly higher and ejection fraction was significantly lower in thalassemia patients. H-FABP has positive correlation with BNP, left ventricular dimension, pulmonary pressure, serum ferritin and the duration of blood transfusion. Conclusion: Elevated H-FABP is associated with myocardial dysfunction in otherwise asymptomatic thalassemia patients.

The peculiar anatomy, muscular attachment, and thickness of cortical plate which is interposed between the thicker tooth‑bearing mandibular body and the thinner ascending ramus in addition to the presence of the third molar makes the angle region of the mandible irreplaceable. Innumerable treatment modalities have been proposed for mandibular angle fractures; although the ideal modality remains controversial. The choice of fixation in maxillofacial skeleton should be reformed based on the fracture patterns, displacement, stability of segments, and satisfactory postoperative function. However, due to the varied fracture patterns, there arises a need for variation in fixation devices and their localization. We put forth a case of a mandibular angle fracture displaying a unique fracture pattern and its management along with a brief review and update pertaining to the way mandibular angle fractures should be managed

Cancer treatment suffers with the failure of chemotherapeutic agents because of multi drug resistance. Investigation of new molecules involves huge expenditure and time. Present investigation aims at the dual loading of anticancer agent Imatinib Mesylate along with Piperine on to bovine serum albumin nanoparticles in order to overcome multi drug resistance and to achieve the maximum therapeutic effect. Desolvation method with the addition of acetone is used to prepare the nanoparticles. Drugs and polymer are subjected to differential scanning calorimetry. Nanoparticles are evaluated for encapsulation efficiency, particle size, zeta potential and drug release studies. In-vitro anticancer activity of the nanoparticles against Human Glioblastoma Multiforme (GBM) cell line T98G is determined. Results indicated compatibility in DSC, an encapsulation efficiency of 52.456%-88.254%, particle size of 208.3nm -497.3nm, zetapotential of -16.5mV to -63.2mV and drug release of 86.256% to 94.56% in 24H. In in-vitro anticancer activity % of cell death is 68.257% to 79.658%. Results suggest increased anticancer activity with the nanoparticles dual loaded with Imatinib mesylate and Piperine.