The burden of infectious diseases by bacteria and fungi had constituted a great concern to the entire human population. Calliandra portoricensis (Fabaceae) had been widely used over the years in ethnomedicine for the; treatment of various ailments such as swollen gum, tooth and throat inflammation often associated with microbial infections. At present, no active antimicrobial compound has been reported from this specie. The aim of this research was to identify, isolate and characterize the antimicrobial compounds from the root of C. portoricensis. The pulverized root sample (0.8 Kg) was extracted by successive cold maceration respectively for 72 hr.. The most bioactive ethyl acetate extract (4.61 gm) was subjected to chromatographic column fractionation (Silica Gel G, 200-400 mesh-stationary phase). Gradient mixtures of n-hexane: ethyl acetate: methanol (4:0:0; 3:1:0; 2:2:0; 1:3:0; 0:1:0; 0:3:1; 0:2:2; 0:1:3; 0:0:4; – v/v/v) were used for elution. Agar well diffusion method was adopted for the bioassays susceptibility tests and MIC determinations. Clinically viable human pathogens for the tests were; Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Klebsiella pneumonia, Streptococus fecalis, Candida albicans and Aspergillus niger. Two major fractions (FA and FB) active against the test organisms were pooled The more active fraction FB on further purification by preparative TLC (Silica Gel G, 0.5 mm thickness), yielded bioactive pure commands C1 (9 mg) and C2 (8 mg). Both compounds exhibited MIC values of 125.00±0.70 µg per ml against Candida albicans and Aspergillus niger These activities were found to be quite significant with respect to the reference controls (Ciprofloxacin and fluconazole) at P < 0.05. Characterization of C1 and C2 by spectroscopic analysis (UV, MS, FT – IR and NMR), identified two novel compounds as Cassane - type tricyclic diterpenoids. C1 (Molecular Mass: 324, C20 H36 O3) is (5,10- 8,9- 12,13)-seco- 4,4,10 – trimethyl, 14 – hydroxymethyl, 16 – keto, 13(15) – ene – cassane furanoditerpene and compound C2 (Molecular Mass: 418, C24 H34 O6) is (12,13) – seco - 12, 14 – epoxy, 12(16) -Oxo –,13(15), 16(17) – diene, 4, 10, 17 – trimethyl, 4, 7 – di – aceto cassanoate. Similar Cassane - type diterpenoids have been reported for promising antimicrobial properties.

Human nutrition is the process by which substances in food are transformed into body tissues and provide energy for the full range of physical and mental activities that make up human life. Antioxidants that usually taken through diet and have an important role in inhibition of stress due to oxidation that reason for beginning and development of numerous diseases such as cancer, and much other disease such as diabetes and also inflammation. There are certain gaps in literature about the different activities in compounds that exhibit functions in vegetables and fruits. Different free radical leads to oxidative stress to the particular cell and ultimately causes the cancer. The natural phenolic compounds have received increasing interest in the last years, since a great amount of them can be found in plants and consumption of vegetables and beverages with a high level of such compounds may reduce the risk of development of several diseases due to their antioxidant power, among other factors. Kaempferol as one of the flavonoids that main function involved in binding with cells of the cancer and ultimately kills the cancer cells. Anthocyanin mainly the type of the major compound in the outer portion of the skin of the onions The colour of the red showing the activities against the free radicals depending on the type as well as the nature of the chemical compound. Quercetin as the valuable type of the flavonoids that have been used in the purpose of the preventing diseases associated with the bacteria as well as the viruses. Different free radical leads to oxidative stress to the particular cell and ultimately causes the cancer.

Background: Asthma still the mainly prevalence chronic respiratory disease affecting individuals in different ages. The objective of this study was to find out the prevalence of asthma, and its triggering factors among medical students in the College of Medicine University of Hai'l city, Saudi Arabia. Methodology: The study investigated 198 students using online questionnaire. Results: The 198 male medical studentsaged between 20 -27 years with mean age of 21.5. The overall prevalence of asthma in in the medical students at the College of Medicine University of Hai'l was 10%.Regarding to things that aggravates asthma symptomsdust 5/20(25%), smoke 2/20(10%), dust+smoke 4/20(20%), dust+stress 1/20(5%), dust+smoke+stress+animals 2/20(10%), dust+smoke+cold weather 3/2(15%), dust+animal+stress 1/20(5%) and dust+coldweather+animals 2/20(10%). Conclusion: The prevalence of asthma in medical students is relatively high compared to global prevalence rates. The most common allergies triggering asthma symptoms in the college of Medicine, university of Hail, are dust, smoking, Animals and stress.

Background: The management of prostate cancer may be difficult due to apoptosis resistance. HIF-1α (Hypoxia inducible factor 1α) and CypA (cyclophilin A) over expression promotes this resistance. Caspase 3 is a central executioner of the apoptosis pathway. Changed expression may correspond to tumor cell challenge. Aim: Evaluation of HIF-1α, CypA and Caspase 3 expressions in BPH (benign prostatic hyperplasia), PIN (prostatic intra-epithelial neoplasia) and PCa (prostatic carcinoma). Methods: One hundred four patients with histologically diagnosed prostatic carcinoma, 20 cases with BPH and 24 cases with PIN were investigated. Immunohistochemical assessment was executed to evaluate HIF-1α, CypA and Caspase 3 expressions. Results: In BPH cases, HIF-1α, CypA and Caspase 3 were expressed in 20%, 30% and 60% respectively. In PIN cases, HIF-1α, CypA and Caspase 3 were expressed in 33.3%, 41.7% and 41.7%, respectively while in PCa cases, HIF-1α, CypA and Caspase 3 were expressed in 57.7%, 69.2% and 25% respectively. Increasing stage of prostatic cancer showed a significant increased HIF-1α and CypA immuno-expression with lost caspase 3 immuno-expressions. Conclusions: Distorted HIF-1α, CypA and Caspase 3 expressions may act as a further mechanism of apoptotic resistance in prostatic carcinoma treatment.

This research examined 12 factors most associated with and predictive of corporate strategy execution in the United Arab Emirates’ steel manufacturing industry. It embraced a positivism research philosophy and quantitative methodology through respondent surveys (n = 112) and a case study (n = 80). Correlations between data sets were calculated using Pearson and Spearman correlation and multiple regression; t-tests, ANOVA, and Tukey–Kramer post-hoc statistical tests were also used. Participants perceived their organization’s strategy as being of high quality, with a statistical significance level (t [111] = 21.50; p < .001). Participants were satisfied with their organization’s strategy execution, with a statistical significance level (t [111] = 18.62; p < .001). Of the 12 factors, three represented statistically significant predictors (p < .05) of the perceived efficacy of strategy execution: clear guidelines, harmony between the execution plan and the power structure, and the organization’s ability to adapt to change. Hypothesis testing found that the higher the hierarchy level, the higher the number of respondents who strongly agreed with the survey questions related to the 12 elements. Organizations need to define power bases and form coalitions with those in power; focus on value-added, measurable results; and ensure that resources are fairly distributed. Furthermore, organizations need to assess the size of the strategic change and the time needed to execute it, outline the steps and tactics, clearly identify responsibilities and accountabilities, and overcome resistance to change, including cultural change.

The phosphate solubilizing bacteria are soil microbe can dissolve P which is not available to become available to plants. They have capable to produce extracelluler enzyme, i.e. group of phosphatase enzyme which able to mineralized of organic P to inorganic P. The objective of this experiment was to examine compatibility test, phosphatase enzyme activity and phosphate solubility by phosphate solubilizing bacteria. The compatibility test was conducted qualitatively with the streak method. The design for bioassay of phosphate solubilizing phosphate for phosphatase activity test and P solubility was a randomized block design with five treatments and five replications. The phosphate solubilizing bacteria used were Burkolderia sp., Pseudomonas mallei, Bacillus substilis, and Bacillus megatherium. The results of the compatibility test on the phosphate solubilizing bacterial isolates showed that each isolate was compatible. Furthermore, the result of experiment revealed that phosphate solubilizing bacteria could produce phosphatase enzyme ranges between 4,53-4,82 µg pNP/g/h and P dissolved about 3909,55-6052,19 ppm. These phosphate solubilizing bacteria can be used as biofertilizers to increase soil P solubility.

Program Evaluation is the systematic gathering of information for purposes of making decisions. After the development and establishment of e learning program, Pak Red Crescent Medical & Dental College (PRCM&DC) were made with the help of the Medical Education Department a program evaluation questionnaire based on all frequently asked questions send to all students by e evaluation form. All the students who have The Students who have internet facility and attend the classes regularly are included. Student’s response rate is 34.88%. Reliability coefficient of the questionnaire is 0.822. Majority of the students found the clear objectives of the subject and interactive teaching decrease the anxity. Students were satisfied with learning material which is provided by the facilitators like lesson plans, course notes, handouts books and important notes are very helpful. Many students agreed that they were encouraged to asked questions and give answers during lectures, and most of them were satisfied with the delivery and pace of lecture. Majority of the students were satisfied with the present teaching through e learning method. They were well understood the teaching and learning material and also were appreciate the organization of the thought material.

Advances in technology, information and communication make it easy for citizen, especially in Indonesia to find and disseminate information on the spread of Corona Virus Disease 2019 (Covid-19), especially the emergence of the citizen journalism movement that has found a "new life", ordinary people, not journalists, it can create news and distribute it globally. Media company provides oppurtunity to broadcast and publish the news and the information derived from citizen journalism. The existence of citizen journalism has changed the role of the public, which has been the object of news or audience, to become like the professional journalist. Journalistic activity by the citizen journalism in the situation of the spread of the Corona Virus Disease 2019 (Covid-19) pandemic, it must receive legal protection as the guarantee for citizens in spreading truthful information for the public interest.

Interpersonal relationships among professional church staff are an inescapable reality for all those working in Christian organizations, and improving such a relationship is the function of effective and efficient leadership. It is in the context of these relationships that both the church staff and the entire congregation find fulfillment in gathering for a worship experience. However, interpersonal relationships are both negative and positive with implications on the effectiveness of staff members at work, the congregation as well as the growth of the ministry. Leaders with this tendency must possess the appropriate skills for productive relationships among the staff members, be able to apply the skills appropriate for excellent and rewarding results, having an understanding of the complexity of human nature. An understanding of the concept of interpersonal relationships existing among church staff and improvement on the positive interpersonal relationship expected among church staff as well as its implications to attract the divinity from the transformational perspective is the thesis of this article.

This research aim is to examine and analyze the weaknesses of the implementation of the auction execution of the object of the Mortgage especially in determining the auction price which is not yet based on Justice Value to then create a reconstruction of the execution auction of the Guarantee Rights in determining the auction price based on justice value. This research uses the method of empirical juridical approach where the data used in this study are primary data and secondary data, using qualitative analysis. The results showed that the weaknesses can be seen in Law no. 4 of 1996 concerning Mortgage Rights on Land and Objects Related to Land and Article 43 and Article 44 of the Minister of Finance Regulation No.27 / PMK.06 / 2016 concerning the Implementation Guidelines for Auction in determining the limit value made by an independent appraiser is in fact without any supervision by the supervisory agency for that and also without clear regulations regarding how to determine the auction price / auction limit value. To be able to resolve this, it is necessary to reconstruct the execution of the guarantee of the Guarantee Rights in determining the auction price based on Justice Value, namely in Article 6 and Article 20 paragraph (2) of Law No. 4 of 1996 concerning Mortgage Rights for Land and Objects Related to Land and Article 43 and Article 44 of the Minister of Finance Regulation No. the debtor and the creditor and if the auction price is not agreed upon, the settlement regarding the determination of the auction price shall be settled through the court so that the determination of the auction price can met the justice value.

Physical activity has been considered as an effective strategy for both physiological and psychological benefits. Though its effects are well documented among adolescents and adults, but it has not been studied extensively in middle aged people. Therefore, the objective of the present study was to see the effect of physical activity on perceived stress, sleep quality and happiness among middle aged people. Total 455 participants (males=197, females=258) in the age range of 40-60 years were recruited for the present study. To assess the domains of physical activity, perceived stress, sleep quality and subjective happiness, Godin-Shephard Leisure Time Exercise Questionnaire (Godin, 1985), Perceived Stress Scale (Cohen et. al., 1983), Pittsburgh Sleep Quality Index (Buysse, et al., 1989) and Subjective Happiness Scale (Lyubomirsky & Lepper, 1999) were used respectively. Obtained scores were subjected to two-way analysis of variance. Findings of the study revealed significant effect of physical activity on perceived stress (F= 3.34; p< 0.05) and sleep quality (F = 387.036; p< 0.01). But, physical activity did not produce significant effect on subjective happiness among male and female participants. The study indicates that physical activity plays a vital role in enhancing sleep quality and reducing perceived stress among middle-aged people. The significant implications have been discussed.

Nile tilapia belongs to the family Cyprinidae. All fishes are at risk of pathogenic and other microbes, because fishes are contain by environment which is rich in microorganisms. Fish exist in environment of water which is useful because mucus is produce from the body of fish and protect against the large number of microbes which are present in the water. Usually the body of fish is protected by the layer of mucus and the mucus contain many kinds of biological constituent in the outer layer, these are the mucus cells, the club cells and the epithelial cells. The fish immune system is very important. The fish mucus having several unwilling defiance parameter which are immunoglobulin’s, pathogen peptide and harmonize factors that provide both physical and machinal protection. Important part of the fish mucous defense system is immunological defense that is present in mucus of fish’s skin, helping as a physiological and structural barrier against outside risks. Genetic makeup and evolutionary lineage determine the innate immune system of pathogens that are modified through time, pathogenic association and environmental factors.

The presence of a foreign body in the middle ear is a rare clinical situation. They represent 1% of otologic disorders and less than 0.4% of all consultations in emergency services [1, 2]. This accident is a real emergency which sometimes threatens the vital prognosis. It poses two problems concerning its location and its extraction. We report the clinical case of a patient followed for chronic otitis media who accidentally introduced a metallic foreign body into his right middle ear.

Mousetrap appliance is an effective treatment modality for anterior open bite that utilizes implants inserted into the anterior palate and brings about open bite correction by intruding the maxillary molars. This is a finite element study that assesses the stress contours at the bone mini-screw interface, when the maxillary molars are intruded by a mousetrap appliance. Materials and Methods: A finite element model of the maxilla and the mousetrap appliance made of 288332 elements and 64771 nodes was generated using software tools like MIMICS and HYPERMESH. A simulated force of 100 grams was applied to the maxillary molar through the appliance and the stress contours were assessed. Results: In the cortical bone Von-mises stress at the bone mini-screw interface was around 13.2MPa whereas in the cancellous bone it was around 0.198MPa. Conclusion: It is therefore concluded that the mousetrap appliance which exerts a force within the range of recommended force for molar intrusion generates stress contours at the bone mini-screw interface in cortical as well as cancellous bone. More stress is generated in the cortical bone.

UV-B is a growing concern due to the rise in UV-B levels on the surface of the earth as a result of the loss of stratospheric ozone. Increased levels of UV-B radiation can in fact negatively alter plant physiological processes, growth and productivity. However, when researching the effects of UV-B on medicinal plants like Phyllanthus amarus and in the tropical area under field conditions, there are some curious phenomena have been discovered. Enhanced UV-B radiation has greatly improved the growth of P. amarus. The outcome of the photosynthetic pigment showed increased UV-B enhanced synthesis of Chlorophyll or the accumulation of Chlorophyll pigments in the treated plants compared to non UV-B treated plants. The concentration of UV-B absorbing pigments also increased due to enhanced UV-B radiation in P. amarus. The synthesis of secondary metabolites such as flavonoid and phenol content was increased under UV-B treatment as compared to control. The UV-B radiation enhances the grade of the medicinal plant by improving the medicinally active compounds. This enhanced impact of UV-B could be important to observe when studying the phytotherapeutic function of P. amarus in health aspects of human life.