Background: There are many types of arthritis, but osteoarthritis (OA) is one of the most frequent. IA injections of corticosteroids into the knee joint may improve pain and impairment by relieving joint inflammation. Purpose: To evaluate the effectiveness and safety of hylastan, a novel viscosupplements, with a single intra-articular corticosteroid injection in the treatment of knee osteoarthritis pain (OA). Because of its large molecular weight, the sodium hyaluronate in Hylastan is more likely to stay in the joint for an extended period of time than other viscosupplements. Methods: Multicentered based randomized quasi-experimental comparative study was performed in Shah Mokhdum Medical College, Rajshahi, Bangladesh, from January 2019 to December 2021. Enrolled patients aged ≥40 years. Patients were randomized 1:1:1 to one of three arms: 2 X 4 mL hylastan (n = 129; arthrocentesis then IA hylastan Day 0, same treatment Week 2); 1 X 4 mL hylastan (n = 130; arthrocentesis then IA hylastan Day 0, arthrocentesis only Week 2); steroid (n = 132; arthrocentesis then IA methylprednisolone acetate 40 mg Day 0, arthrocentesis only Week 2). The primary clinical outcome measure was changed from baseline in WOMAC A pain score overall postbaseline visits to Week 26. Results: Statistically significant pain reduction was observed in all three arms, with similar mean (95 % CI) changes in WOMAC A: 2 X 4 mL hylastan -0.9 (-1.0, -0.7); 1 X 4 mL hylastan -0.8 (-0.9, -0.7); steroid -0.9 (-1.0, -0.8); all p < 0.0001 versus baseline. Changes in secondary outcomes were similar in all three arms. Target knee adverse events were comparable for all treatments. Conclusions: An acceptable safety profile and effective pain relief were found with both IA hylastan injection regimens. The hypothesis of better pain relief with IA hylastan was not met compared to IA corticosteroid. The effectiveness and safety of hylastan compared to other viscosupplements require more investigation. Level of evidence Therapeutic study, Level I.

Date palm tree (Phoenix dactylifera L.) is an important crop or khajoor in the local language which is cultivated in many countries. Different types of dates are present but Ajwa khajoor is very beneficial in cardiovascular activity, heart disease, antimicrobial, nephroprotective, antioxidant, anti-inflammatory activity, provide relaxation during pregnancy, reduce risk of tooth decay, improve bone health, and also provide mental clarity. Prophet Muhammad (Peace Be upon Him) said that the best assets are date palm, dates cure several disorders, and he suggested Muslims to eat the date and have a tendency the date palm. Dates play key role in anti-cancer activity, anti-tumor, cardio-protective activity, and neuroprotective activity. Dates fruits and seeds are considered essential nutrients and medicines. They can be used in a variety of cosmetic and beauty products. Many cosmetic products contain high levels of chemical compounds, commonly found in synthetics such as hydroquinone. Date seed oil has been shown to have a positive effect on human skin and hair, as well as a few products (body creams, soaps, hair products, and sunscreens) are sold. Seed oils have high oxidative properties, extended storage capacity, and can protect the skin from UV rays and repair it. Bioactive compounds, such as flavonoids and phenolics, can prevent hair loss and promote hair growth. The extracts from dietary seeds are rich in phytosterols, essential fatty acids, and nutrients needed to maintain healthy scalp, promote normal hair growth, and support nourishing functions of sebaceous glands and hair follicles. It is important to all synthetic skincare products and medically very beneficial.

Background and aim: Inflammation has been long regarded as a key contributor to atherosclerosis. Recent decades have provided extensive and mounting evidence concerning the pivotal interplay between inflammation and CAD, reinforcing the concept of inflammation not only as a risk marker but also as a risk factor for the development and progression of atherosclerotic disease. Methods: This was a case control study that has been enrolled among 404 patients, divided into two different groups (case-CAD patients and control group-Patients with Normal Coronary Angiography) that presented to Catheterization unit of Surgical Specialty Hospital- Cardiac Center/ Erbil City-Iraq from 1 Sept 2021 to 1 Jan 2022. Results: A total of 404 patients of case and control group was included from both genders, the mean age was 55.9 ±10.6, ranging from 30 to 77 years of age, based on their coronary angiographic profile 57.4% of them were Coronary Artery Disease cases and 42.6% were controls. (58.4%) of the study population were males and (41.6%) were females. The mean of CRP level amongst cases were higher (6.2 ± 10) than the controls (3.5 ± 4.7), and this was significant with a P = 0.022. In our study we found that Highly Sensitive-CRP was high amongst Case Group (Patients with CAD) by 70% while comparing to only 30% of Control group who had High CRP levels. And this was statistically significant with a P value of 0.003. Conclusion: The level of CRP was higher among patients with Coronary Artery Disease, than those with Normal Coronary Angiography. The level was higher among.

Introduction: According to epidemiological surveillance in Mali in 2013, the prevalence of HIV/AIDS infection is high among pregnant women in the Ségou region. Objective: The aim of our study was to study the knowledge and practical attitudes regarding HIV/AIDS of pregnant women followed in prenatal consultation in the gynecology-obstetrics department of the Nianankoro Fomba hospital in Ségou. Method and material: This was a prospective descriptive cross-sectional study that took place from September 1, 2019 to April 31, 2020. Included in the study were all consenting pregnant women seen in prenatal consultation (CPN) or in labor at the hospital. Results: The seroprevalence of HIV/AIDS in our study was 1.4%. The age group of 20 to 29 years was the most represented in our study with 51.1% of cases with an average of 26.5 years. The pregnant women were housewives in 96.1% of cases. The main source of information for pregnant women on HIV/AIDS was television (44.2%). The best-known mode of transmission was sexual (47.7%) and weight loss was considered the main sign of HIV by 27.5% of the pregnant women questioned. The VH screening rate was inversely proportional to the level of education P=0.062. About 82.3% of pregnant women favored psycho-emotional support for people living with HIV (PV-HIV). The acceptance rate of pregnant women for HIV/AIDS screening was 87.8%. The fear of being stigmatized (46.0%) was the frequent reason for refusing the screening test. Fidelity was cited as the main means of preventing HIV transmission by 35.7% of pregnant women. Conclusion: Our study reveals that the level of knowledge of pregnant women on the modes of transmission and measures to prevent mother-to-child transmission of HIV/AIDS is generally good. However, awareness should always continue to bring the reluctant to take the screening test.

Testing and assessment of learning outcomes are one of the basic and important tasks in the educational process. For many years, this activity has been paid special attention by Vietnam’s education sector and included in the industry’s key action program. For this activity to achieve good results, management plays a key and necessary role. Documents of the Ministry of Education and Training indicate the necessity of this activity. However, this activity has not achieved good results in some high schools. Many negative phenomena have arisen during the implementation process. In the current educational innovation context, this activity is becoming more and more necessary. This study indicates the need and proposes solutions to test and evaluate learning outcomes to achieve better results in the future.

The most common surgical emergency encountered during pregnancy is acute appendicitis [1]. The diagnosis of acute appendicitis during pregnancy is often challenging mainly because of physiological and anatomical changes during pregnancy. From a therapeutic point of view, the approach depends on the gestational age and the evolutionary stage of the appendicitis. The maternal-fetal prognosis depends on the severity of the condition and the delay in treatment. Appendectomy should be performed in patients presenting a highly suggestive clinical and ultrasonographic picture, preferably by laparoscopy in order to avoid more severe complications which could be life-threatening for the mother or infant.

The word "fraud" is a word that exists today. There are no business entities or institutions that are entirely devoid of the risk of fraud. People who commit crimes can be found in every socioeconomic class. As a result, there's a requirement for various stakeholders to be concerned and aware of the possibility of fraud in the workplace. The purpose of this research is to study the impact of role conflicts, workload, and internal auditors’ ability to detect fraud. Collecting data using a questionnaire which is measured by a Likert scale. The population in this study were all internal auditors of the Inspectorate General of the Ministry of Education and Culture. The saturated sample consisted of 300 respondents. The data analysis method uses SEM-PLS modeling through the SmartPLS version 3.0 program. By testing the validity, reliability, R Square value, F Square value, Q Square value. Testing the hypothesis using the bootstrap T-test method. The results of the study stated that role conflict and time burden had a negative and significant effect on professionalism, but competence had a positive and significant effect on professionalism, role conflict, and time load had a negative and significant effect on the ability to detect fraud, but competence and competence. professionalism has a positive and significant effect on the ability to detect fraud. Role conflicts, time, and professional burdens can affect the ability to detect fraud indirectly through professional mediation. This study requires careful planning and clear authority and responsibility to conduct field audits and the need to increase competence to increase the professionalism of auditors in detecting.

Good quality of air in poultry farms is a prerequisite for healthy animals and farm workers. Air acts as a good dispersal medium for microbes and its quality is a reflection of the environment. The focus of this study is was evaluate indoor and outdoor fungal flora of two poultry farms (Akungba-Akoko and Ayegunle-Akoko) and to determine effect of some antifungal agents on all isolates. Identity of each fungus was determined by comparing the morphology and microscopic characteristics of each fungus with those in compendium of soil fungi. Air flora sampling was performed both inside and outside premises of farms, and an open-air method was used. Antifungal activity was performed using two antifungal drugs (ketoconazole and nystatin). A total of twenty-three (23) fungal species were obtained belonging to fourteen (14) genera; Aspergillus, Penicillium, Eurotium, Monascus, Alternaria, Cryptococcus, Curvularia, Chrysonilia, Microsporum, Cunninghamella, Bipolaris, Acremonium, Fusarium and Trichoderma. Genera such as Curvularia, Chrysonilia, Cunninghamella and Cryptococcus were not inhibited by antifungal drugs used across all concentrations, while nystatin inhibited 74% of these fungi using concentration of 5 mg/ml with 25 mm being highest zone of inhibition. Ketoconazole’s highest zones of inhibition were found with Alternaria tenuissima (26 mm), Trichoderma harzianum (25 mm) and Aspergillus acidus (25 mm). The study revealed presence of some toxicogenic fungi in poultry environments. Therefore, this study recommends preventive measures like provision of adequate ventilation system, regular cleaning of poultry farms, use of clean equipment, and use of antifungal drugs such as ketoconazole and nystatin (to be used at low concentration) to inhibit and control infections in poultry farms.

Cellular cultures can be used to investigate the role of ciliates in forming of flocs of fishes in the absence of many other microbes. Aquaculture is rapidly expanding and faces numerous difficulties in achieving growing demands while maintaining the security and suitability of fish products. The primary motivation for developing fish cellular cultures, as till recent times, the most common application of these cultures, has been the exclusion and description of fish viruses which are the causal factors of epizootics in economically valuable aquaculture or fishery. Acinetobacter, Vibrio, and Pseudomonas grow faster in flesh media than in artificial media. Fish-protein-hydrolysate peptones have no interaction with prions which cause bovine spongiform encephalopathy. Tissue engineering can all be combined with advanced aquaculture technologies to make marine cellular cultures as an appealing option for producing in vitro fish meat. Fish waste products could be an interesting perspective of cost effective and efficient peptones, the use of which has resulted in good growth yields for a wide range of bacterial genera. Food loss starts immediately as the fish killed, so handling should be completed as soon as possible to avoid the development of bacteria and molds on it.

COVID 19, caused by severe acute respiratory syndrome – corona virus -2 (SARS – CoV 2), is a pandemic that affected millions of people worldwide. During the second wave of COVID -19 pandemic in India, an unprecedented surge in cases of mucormycosis was observed. This study was carried out to describe the clinical, morphological and histopathological staining characterstics of mucor mycosis in 16 covid patients in a tertiary care setting. Older patients with comorbidities like diabetes mellitus are commonly affected. The most common site of involvement was sinonasal tract (68.75%) followed by sinonasal tract and orbit (37.5%). Out of the 16 patients, 2 were partially vaccinated whereas others were not vaccinated. Histopathological examination of specimens revealed broad aseptate fungi in all cases. Tissue necrosis was present in all cases. Suppuration being the most common tissue reaction. 43.75% showed angioinvasion and 37.5% had bone invasion. All the cases were GMS positive with variable intestity. Treatment given in all cases were liposomal amphotericin B injection and surgical wound debridement. On follow up, 40 % of the patients died inspite of aggressive clinical management. Hence this fatal fungal infection should be kept in mind in covid 19 recovered patients especially those who are immunocompromised.

Negative experiences on an internship can adversely affect the attitude and confidence of nursing students. This highlights the need to explore the experiences of nursing students as they progress through their training. The present study examines the challenges and problems faced by nursing students during their internship program at a hospital in Medina, Saudi Arabia. The study employed a qualitative exploratory study design by recruiting eight nursing students. Face-to-face semi-structured interviews were conducted to gather data. Moreover, the data were thematically analyzed. The major challenges and problems experienced by the nursing students were lack of support, distrust, improper behavior, and absence of a preceptorship program. There is a negative impact of these issues on nursing practice in clinical settings. The study concludes that positive outcomes are likely to be achieved by improving the internship program.

Ciliated hepatic foregut cysts (CHFCs) are a benign cyst of the liver with a ciliated coating. It is an extremely rare solitary cystic lesion. In this paper, we present a case of CHFCs in a 41-year-old woman. Our goal was to insist by the report of this clinical observation and the review of the literature on the main issue of this pathology which is to ensure a regular and rigorous monitoring of patients with CHFCs or a radical surgical treatment to anticipate or avoid malignant complications.

Nano-pesticides are essential for the successful and sustainable management of different pests, and they can decrease the use of agrochemicals, thereby mitigating current environmental dangers. Nevertheless, advancements in nano-particles or micro-particles, as well as distribution models for biolistic gene delivery in various plants, are still needed to enhance grain growth and crop and plant protection. , seed priming is being used effectively to expedite and synchronize germination, increase seedling vigor, and make plants extra resilient to various biotic and abiotic stresses, resulting in increased efficiency and quality of food. Nano fertilizers have distinct properties like mega absorption, increase in production, enhanced activity of photosynthesis, and a substantial improvement in leaf surface area. Growth of plants is changed to a particular environment conditions at different phases of development; and hence, a proper choice of planting date increases photosynthesis efficacy. In this perspective, providing carbon nano-tubes in to the chloroplasts has resulted in a progress for plants' enhanced capacity to collect more energy from the sun. Lower rates of photosynthetic activity in the crop plants under the cold stress limited metabolic pathways for Carbon assimilation.

Recent advances in physics have been made through nanotechnology that employed the nanoparticles and provide the physical and chemical basis studies of various compounds. In this regards, various branches of physical such as atomic, molecular, nuclear, thermodynamics and photonics all also made several recent perspectives in their main areas. Many photonics based objected have been designed through advances in nanotechnology for example, nature of opto-electronics as it now becomes possible to imagine using coherent light produced on a chip to control electronic interactions on the same chip. The new technologies are focusing on the development of quantum physics has applied to the nanoscale systems in order to understand the as quantum sensing. Molecular physics associated with combinations of the nanoparticles intergraded with atoms and hybrid systems that would be helpful for the ultrasensitive sensor devices that are most efficient and no environmental hazards while some of the old and traditionally used devices and machines are poorly understood with noise pollution and no significant in their preparations. As, quantum computing is based on physical materials, the choice of material is important and semiconductor materials. The newly solar cell technology has been also folding the nanoparticles coating to the adhered materials of the solid surfaces for when surface plasmon is located in front of a solar cell. Microwave plasma-enhanced also applied for the different applications of diamond films. X-ray diffraction for thermodynamic based materials also important because of the some phenomenon happening in nature deals with heat, work and temperature, and their relation to energy.

The objectives of this study are: (1) to analyze the development and contribution of micro small and medium enterprises (MSMEs) partnerships in the Automotive Industry sector in Indonesia; (2) analyze the pattern and principle of partnership of MSMEs in the Automotive Industry in Indonesia; (3) analyzing the support of the central and local governments for the automotive industry partnership in Indonesia; (4) explore the placement of MSMEs in the National Industrial Estate and (5) develop a strategy for developing and expanding the partnership of MSMEs in the automotive industry in Indonesia. The methodology used is descriptive exploratory and SWOT analysis. The results of the study: (1) inductive statistics give the results that there are 1,474 Number of 2-wheel and 4-wheeled 2-wheeled automotive MSMEs with 2 wheels as many as 659 and 815 4 wheels in Indonesia, West Java by 66%, Banten by 14%, East Java 9%, DKI Jakarta 5%, Central Java 4%, and Riau Islands 1% and other provinces below 1%; (2) partnership patterns and principles in the form of agreements/contracts/supply chains of automotive partnership cooperation between MSMEs and large automotive companies; (3) government support regulations to form a special village center for MSMEs, Link & Match partnerships, People's Business Credit Programs, provide direct cash funds to MSMEs during the COVID-19 epidemic; (4) MSMEs have not yet been placed in Industrial Areas mandated by Law Number 40 of 2007 and Government Regulation Number 142 of 2015 and (5) the position and strategy of MSMEs is an aggressive maintenance strategy and a selective maintenance strategy.