The most frequent type of head and neck cancer is oral cancer (mouth cancer). It usually affects adults over the age of 60. Oral cancer affects your lips, the tip of your tongue, and the roof and floor of your mouth. It also affects the oropharynx, which includes the last section of your tongue and the roof of your mouth, as well as your tonsils and the sides and back of your throat. It is getting a global threat. Excess consumption of Tobacco and alcohol are the key factors of Oral cancer. Sesbania grandiflora is a medicinal plant found in most of the regions of Asia including India. It is full of medicinal properties. Here, in this investigation 33 reported phyto compounds are taken from Sesbania grandiflora and undergone various in silico study. Here, the highly expressed HER 2 protein in oral cancer is targeted. The compounds which pass in computation investigation were docked against the HER 2 protein of Oral cancer. The Sativan was found to be the highest binding affinity scoring molecule among phyto selected from this plant and expected to stop the over expression of HER 2 protein and future drug candidate .

What did we learn after two and a half years into the COVID-19 pandemic and variants regarding Brazilian higher virtual education? This article revisited the issue, providing an overview of lessons about the challenges and pitfalls of virtual learning and the challenges faced by teachers, and executive education professors in Brazil, regarding live online classes via the Zoom platform through archival research and qualitative interviews. Key findings pointed out (a) a drastic increase in the offer and the number of enrollments and admissions in distance courses instead of classroom teaching, but with fewer conclusions; (b) internet connection issues, (c) increasing absenteeism, (d) distractions, (e) dispersion, (e) lack of interest, and (vi) limited pedagogical resources as barriers to online live classes dispensed with the Zoom platform. This study aims to provide the academic community with a perspective regarding the online live education experience after COVID-19 in Brazil. Finally, this work provides ten lessons learned during the pandemic.

The problem that occurs in university study programs is when accreditation is carried out suddenly and unplanned in a structured application system. This condition has an impact on the less than optimal accreditation value. The purpose of this science and technology application is to implement the application of a quality improvement system for study programs based on national accreditation standards. The method of activity with the application of science and technology through the application of application systems, training activities, structured guidance. The target audience is all heads of study programs at the University of Silampari Lubuklinggau (Unpari). The results of the application of science and technology show that the application of a quality assurance system application based on national accreditation standards at universities has been carried out by all study programs and there are 4 (four) study programs that are ready to propose accreditation with national standards. Suggestions require leadership commitment and support from all lecturers for the provision of facilities and funds in accordance with national accreditation standards.

This paper focuses on corruption in tertiary institutions and how it can be tackled through introducing courses and approaches via curriculum development that will build integrity among students, as well as, institutional quality through citizenship and social cohesion. The paper also discussed the concept of corruption, forms of corruption, causes and corruption in tertiary institutions such as bribery, fraud, embezzlement, favouritism, nepotism, among others and its implication for curriculum development in the country. In order to check and eliminate corruption in tertiary institutions, the paper recommended that, social studies, citizenship and value education should be implemented in tertiary institutions to teach about the negative effects of corruption and to create resilience against corrupt practices. Also, stakeholders in education should organize conferences in tertiary institution to re-orientate them on the dangers of corruption with the action statement ‘‘change begins with me’’ in our educational system, effective classroom implementation of curriculum content and the introduction of courses that will imbibe moral consciousness in the business of education at the tertiary level.

Ovotesticular disorder of sex development (DSD) refers to the co-presence of testicular and ovarian tissue in one individual. Here we report a case of Ovotesticular Disorder of Sex Development in a 42 years old male, presented with abdominal mass and undescended testes who had a normal karyotype. Gonadal dysgenesis should always be kept a possibility in patient with undescended testis. Diagnosis relies on clinical findings, hormonal analysis, gonadal histology, chromosome analysis, and genetic testing.

This study aims to criticize the legal construction of multi-stakeholder unions which are not in line with the principles of Pancasila justice. From this critical study, new theories/ideas were generated regarding the system and arrangement of multi-stakeholder unions that are just Pancasila through the reconstruction of Ministerial Regulation no. 08 of 2021 concerning Unions with a Multi-Stakeholder Model using a constructivism paradigm with a normative juridical approach. This type of research is descriptive qualitative. This study uses 4 problem approaches, namely the statute approach, the historical case approach, the comparative approach to law, and the conceptual approach. The legal materials used in this research are primary legal materials and secondary legal materials with data collection methods through library research. Data analysis in this study used qualitative analysis. The results show that the legal construction of multi-stakeholder unions in Indonesia is not in line with the values and principles of Pancasila justice as There is a principle discrepancy between the substance or legal norms of the Regulation of the Minister of Union and Small and Micro Enterprises (PERMENKUKM) no. 08/2021 with the principle of kinship in the 1945 Constitution of the Republic of Indonesia, there is also conflicting legal substances or norms between the lower regulation (PERMENKUKM No. 08/2021) and the higher regulation (Law No. 25/1992 and the Job Creation Law). Then, The existence of material content or legal norms PERMENKUKM No. 08/2021 which exceeds the material limit of a ministerial regulation regulated in Law No. 12/2011 and Law no. 15/2019. Based on this, it is necessary to reconstruct a number of norms in Ministerial Regulation no. 08 of 2021 concerning Unions with a Multi-Stakeholder Model, reconstruction of legal structures or institutions is needed in the form of increasing the ability and understanding of the Ministry of Unions and Small and Medium Enterprises towards Unions and reconstruction of legal culture in the community and union managers.

Background: Hypertension is a non-communicable disease which is an important risk factor for cardiovascular diseases. The prevalence has been documented to be highest in Africa where 46% of the world’s population with hypertension reportedly resides. There is a global concern that hypertension in teenagers and young adults are on the increase and cases are not detected because of inadequate screening in this age group. Objective: To determine the prevalence of hypertension among undergraduates in Rivers State. Materials and Methods: This was a cross-sectional study conducted in Rivers State. The subjects were recruited from University of Port Harcourt, Rivers State University and Ignatius Ajuru University which are the three major tertiary institutions in Rivers State and their ages ranged between 16 and 35 years. Data collected were analyzed using Statistical Package for Social Sciences. Results: A total of 1096 respondents were recruited for the study, there were 570 (52%) males and 526 (48%) females. Sixteen (1.5%) of them were married while 1080 (98.5%) were single. The prevalence of hypertension among the respondents was 21%. Adding salt to meal before eating and noodles consumption were significantly associated with hypertension. Other risk factors which included smoking, alcohol consumption, and physical inactivity, family history of hypertension and/or CVD and use of social drugs were not significantly associated with increased prevalence of hypertension. Conclusion: The prevalence of hypertension was high in this study there was a significant association between hypertension and risk factors such as salt intake and noodles consumption. Health practitioners should enlighten the public on the presence of hypertension in young people. There is also need to create awareness of hypertension even in young adults and promote early lifestyle changes.

The purposes of this study are to analyze and find the weaknesses of the Law on Narcotics Abuser in Indonesia Currently and How is the Reconstruction of the Law on Narcotics Abuser based on Benefit Value in a research that uses an Normative-juridical approach where The data collection method used is sourced from secondary data and primary data which was carried out using qualitative analysis methods. The results of the study show that the Weaknesses of the law on narcotics abuser are in the list of the grade of the narcotics contained in the narcotics law that are not up to date as some of the narcotics in the list have been removed in various countries such as Cannabis. This problem not only causes Cannabis Abuser Prisoned although their position should be as “victim” but also one of the factors that causes Overcrowding in Prison in Indonesia. The reconstruction as intended by the author are not in the form of substantial law reconstruction but rather a structural law reconstruction where the Narcotics Law Article 8 (2) which states that In limited quantities, Narcotics Category I can be used for scientific development purposes knowledge and technology and for diagnostic reagents, as well as laboratory reagents after obtaining Minister's approval on the recommendation of the Head of the Agency Food and Drug Supervisor need to be upheld higher and if necessary to add an extra paragraph in the law to appoint the ministry of health together with National Narcotics Bodies to create a Joint Research Bodies that are obliged to conduct research related to the use of narcotics. By using this approach, not only the law’s narcotics list of grade can be justified and are up to date, the overcrowding problem in the prison can be minimized.

Concrete is used more than water worldwide. The need for Conventional concrete rises in tandem with the demand for concrete as a building material. According to estimates, cement production rose from 1.5 billion tons in 1995 to 4.5 billion tons in 2020. Finding a substitute for Cement concrete, whose production uses the most resources, is therefore inevitable. Researchers have been inspired to create an alternative binder paste to totally replace cement paste by the use of supplemental cementing ingredients such fly ash, silica fume, granulated blast furnace slag, and rice-husk ash. These inorganic amorphous binders will chemically react to form geo polymer concrete, a cutting-edge building material. We use additional cementitious materials in this that react with alkaline activators to create an Al-O-Si-O gel that has a comparable bonding strength to C-S-H gel. Because geopolymer concrete is already somewhat brittle, increasing its flexural and tensile strength is necessary. There are fibres included. In this study, the mechanical properties of geopolymer [M50] concrete with steel fibres were examined by curing it in an ambient condition.

Objective: To estimate prevalence of depression, anxiety, stress and its association with socio-demographic characteristics among patients, waiting prior to elective coronary angiography. Methodology: This cross-sectional analytical study was conducted in National Institute of Cardiovascular Diseases (NICVD). A total of 349 adult patients, waiting for elective angiography were part of this study. DASS-21(Depression, Anxiety, Stress scale-21) was used to assess depression, anxiety and stress among study participants. Data were by using SPSS version 21.0. Chi-square test was performed to estimate the association of demographics characteristics with stress, anxiety and depression. Conclusion: This study concludes that depression and anxiety were significantly associated with educational level and monthly income. Furthermore, stress level was significantly associated with only educational level of the study participants.

This research was carried out to examine the relationship between selected physical fitness characteristics and shooting accuracy among high school basketball players in the Cape Coast Metropolis. Preliminary investigation revealed that the shooting accuracy of basketball players in the metropolis was not good compared to the standards set for players of their age category. Forty (40) basketball players comprising twenty (20) male and twenty (20) female, male with a mean age of 17.15, weight of 73.20, height of 1.79, and female also with a mean age of 17.15, a weight of 68.65 and height of 1.64 were randomly sampled and randomly assigned to experimental and control groups, respectively. The experimental group was taken through drills to improve on selected fitness variables while the control group went through a mini-clinic on passing and dribbling. The mini-clinic was used to occupy the control group for the period of training at a different venue as the experimental group went through specific drills intended to improve on selected physical fitness characteristics which were used as the bases for assessing improvement in shooting accuracy. Because the mini-clinic focused on passing and dribbling, it did not have any influence on their shooting hence difference was identified. Physical fitness tests were conducted using standardized tests; agility was tested with the Illinois agility test, balance with the flamingo test, coordination with the alternate hand wall toss test, power (upper body) was tested with the seated medicine ball toss test, power (lower body) with the standing broad jump, reaction time with the ruler test, and speed with the 40m dash. For shooting accuracy, the researchers adapted the tests used by Pojsic, Separovic, and Uzicanin which are static free throw, dynamic free throw, static two points, and dynamic two points. A dependent sample t-test and Pearson’s correlation were used for analysis. Overall results showed no statistically significant difference between the experimental and control group for both sexes for the physical fitness and shooting accuracy tests at the pretest but at the posttest, there was a statistically significant difference between the two groups. There was also a strong positive relationship between physical fitness and shooting accuracy among high school basketball players in the Cape Coast metropolis. The problem of shooting accuracy among high school basketball players in Cape Coast metropolis can be improved with a planned programme to improve on their selected game-related physical fitness variables.

The purpose of this study is to examine the weaknesses that arise as a result of IPR as joint property that is not regulated in the legislation regarding IPR and develop IPR as joint property and how to distribute it in case of divorce based on justice value. The method used in this research is socio-legal (Socio-legal Research) which uses primary data and secondary data. Meanwhile, the technique of collecting data is through library research and field studies, and Analytical descriptive data analysis. The results of this study indicate that the IPR legislation in Indonesia does not regulate IPR as joint property because it is heavily influenced by the TRIPS (Trade-Related Aspects of Intellectual Property Rights) agreement, none of which mentions IPR as joint property. As a result, it creates weaknesses, including the positive law of IPR that is unable to answer and provide solutions to the problems of joint property that arise in Indonesian society, making it difficult for law enforcers to make decisions on issues of joint property in the form of IPR, the disparity in decisions by one law enforcer with others, and community rights related to IPR as joint property are not fully obtained by the community. This research also proposes legal reconstruction in the form of a new legal norm/rule, that the economic value derived from all types of IPR including Copyrights, Patents, Trademarks, and Geographical Indications, Trade Secrets, Industrial Designs, Plant Variety Protection, and Layout Designs of Integrated Circuits registered during marriage to become a joint property of husband and wife as long as it is not stipulated otherwise in the marriage agreement and the distribution after the breakup of marriage each gets half as long as husband and wife carry out their responsibilities, obligations, and duties properly in the household, if husband and wife are not / less able to carry out their responsibilities, obligations, and duties well in the household, then the distribution is in accordance with the size of their contribution in the household and the process of creating/discovering IPR. The results of the distribution of joint assets either in a decision or an agreement in front of an authorized official must be recorded at the Directorate General of Intellectual Property Rights because the transfer of IPR Economic Rights will only result in legal consequences for third parties after being registered at the Directorate General of Intellectual Property Rights.

Death and dying is a very interesting topic to study. It has however attracted very little historical, socio- cultural and anthropological interrogations. Among the pristine Bukusu people of Western Kenya, death was accorded numerous socio-cultural rituals that constituted coded meanings which may have only been understood in the realms of religion. This paper thus attempted an examination on how traditional religion was a key determinant in conducting death rituals in the precolonial setup of the Bukusu community that was devoid foreign cultural influence. The findings in this paper were however extracted from a Doctor of Philosophy Degree (History) thesis which will be submitted to Graduate School of Laikipia University by February 2023. The broader objective of the thesis has interrogated mortuary and funerary rituals of the Babukusu of Kenya from 1895 to 2010. Being a historical research, relevant information in the study was collected in the field through extensive Oral Interviews (abbreviated as O.I in the footnotes) which was corroborated with other secondary sources to ascertain the relevance of the information.

The Metamorphosis is a novella written by Franz Kafka. This novel tells about a young man named Gregor Samsa who has experienced alienation. This research aims to understand the effects of alienation experienced by Gregor Samsa as a major character in The Metamorphosis. Erich Fromm's theory about three mechanisms of escape is used to analyse the effort of Gregor Samsa in solving his psychological problem of alienation. Modern man usually uses three mechanisms of escape by Erich Fromm to reduce the feeling of fear and isolation of burdened freedom when they want to be free. This research uses qualitative research in which the data are in the form of words and sentences in this novella. This study applies the documentary method as the technique of data collection. The data can be taken from various sources, such as documents, books, and journals. This research shows that Gregor Samsa’s alienation has influenced his entire life, family, and society.

Background: COVID -19 has wide range of presentation, from asymptomatic infection to severe viral pneumonia and death. D-dimer >1μg/ml is one of the risk factors for mortality. CT chest plays an important role in early detection and monitoring of disease. Objectives: 1. To compare D-dimer value and CT chest findings in Covid-19 patients. 2. To study platelet count, PT, aPTT and CRP in Covid-19 patients. Methodology: RT-PCR confirmed Covid- 19 patients admitted in hospital investigated with D-dimer and CT chest were included in the study. Case details retrieved from medical records. Venous blood collected and plasma processed in coagulation analyser for PT, aPTT, INR and D-dimer. Platelet count was performed using auto analyser. CT findings were retrieved from radiology software (PACS). Statistical tests used were mean, percentage and Fisher’s exact test (SPSS Version 20). Results: During study period of January-June 2021, 38 patients were included. Mean age was 51.1±15.6 years and M:F ratio 2.8:1. 65.8% patients had comorbidities (25/38). D-dimer elevated in 60.5% (23/38) patients. CT showed 10.53%, 28.94%, 60.53% of patients had affected lungs of <15%, 15%-49% and ≥50% of the total area and showed significant association with D- dimer (P=0.018). 17.4% (4/23) patients with elevated D-dimer did not survive. 15.8% (6/38) patients had low platelet, 23.7% (9/38) had abnormal PT, 70.3% had abnormal aPTT and 89.5% (34/38) had elevated CRP. There was no significant correlation between platelet, PT, aPTT, CRP and D-dimer. Conclusion: D-Dimer is elevated in COVID -19 patients and shows significant association with lung involvement and can be used as prognostic marker.