The present work mainly emphasized on the enhancement of solubility of Ticagrelor by developing Self- Micro emulsifying drug delivery system. Ticagrelor is a BCS class IV drug with poor aqueous solubility and permeability. The saturated solubility of Ticagrelor in various oils, surfactants and co-surfactants was determined by using UV-spectroscopy. The excipients were selected based on their maximum solubility and compatibility for Ticagrelor. SMEDDS formulations od Ticagrelor were developed using different oils, surfactants and co-surfactant combinations (4:1 and 3:1). Pseudo ternary phase diagrams were constructed and based on pseudo ternary phase diagrams, Nano emulsification area was evaluated .Formulations were designed based on the pseudo ternary phase diagram using various proportions of oil (Capmul MCM E8 EP), surfactant (Labrasol), co-surfactant (PEG-400). The prepared formulations were selected among them F1 was optimized and carried out for further evaluations like dispersibility test, self-emulsification time ,phase separation and stability test, thermodynamic stability studies, droplet size and zeta potential, invitro drug release studies. The results of present study demonstrate that Ticagrelor SMEDDS can be used as a potential means for improving the solubility of Ticagrelor.

Background: Vesico-vaginal fistula (VVF) is still a persisting scourge in the developing countries with devastating medical and social consequences. These consequences were studied among patients presenting with vesico- vaginal fistula in Sylhet MAG Osmani Medical College Hospital, Sylhet. Objectives: To analyzethe vesico-vaginal fistula patients during the 2 years period. Materials and Methods: This was a descriptive and cross-sectional study conducted in the Department of Obstetrics and Gynaecology, Sylhet M.A.G. Osmani Medical College Hospital, Sylhet from May 2008 to April 2010 (2 years).Fifty-three hospitalized patients with vesico-vaginal fistula were selected by Inclusion and exclusion criteria, undergoing repair operation irrespective of age. After selection of the patients informed written consent was taken. Each patient was interviewed using the semi-structured questionnaire containing socio- demographic and other relevant information like age, occupation, education of the patient and her husband, age at marriage, age at 1* child birth, monthly income and detailed history of the delivery. Type of fistula and related examination of the fistula was also done and noted. Type of repair of vesico-vaginal fistula, postoperative complications and outcome was recorded in the same manner. Results: The mean age of the patients with vesico-vaginal fistula was 30.5 years (SD± 8.5; range, 18 to 52). Majority (73.6%) were between 21 to 40 years; and 52.8% patients were primipara, 81.1% patients were illiterate and 69.8%patientswere from lower social class. The aetiology of fistula were obstructed labour 49.1%, emergency lower segment caesarean section 37.7%, destructive delivery 11.3% and caesarean hysterectomy 1.9%.The repair operation was done of all patients in this series through vaginal approach. Repair was done first time in 83% and rest had history of failed repair. Postoperative complications were catheter block and urine leakage in 37.7% and urinary tract infection in 11.3% patients. Successful outcome was found in 79.2% cases. Causes of failure were severe scaring 36.5% difficult operation, catheter block and others each constituted 18.2% and large fistula 1.9%. Conclusion: Young primi are the victims of vesico-vaginal fistula, obstetric causes add up to form a major share of the etiology of vesico-vaginal fistula. Proper perinatal management is most important to reduce obs fistula formation.

Background: Irreversible pulpitis occurs due to infection and other factors. Irreversible pulpitis needs root canal treatment to relieve the pain and achieve restoration of healthy teeth. The success rates of root canal treatment are based on adequate removal of the microorganism and the prevention of the re-growth of microorganisms. However, endodontic treatment isn't always successful. There are many factors affecting the outcome of root canal treatment. Aim: To identify the factors affecting the outcomes of root canal treatment by reviewing the previous studies conducted on this subject. Methods: PubMed, Google Scholar, and Research Gate databases were explored to search for articles related to our subject. The searching process involved using different keywords that were used in different combinations to obtain all possible articles focused on our subject. The inclusion criteria for studies were articles published in 2017 until now, English original and full-text articles. Results: A total of 158 articles were obtained, and only seven articles were eligible for the inclusion criteria. Four studies included treatment performed by dental students. The success rate of treatment ranged between 63.7% and 86.8%. The factors that affected the outcome of root canal treatment were categorized into factors associated with successful treatment, failure of treatment, and factors with no impact on treatment. Conclusion: The success rate of root canal treatment in our analysis was moderate. There were many factors affecting the root canal treatment outcome, including quality of filling, length of filling, and the absence or presence of a periapical lesion.

This study examines the sociolinguistics implication of the use of Nigerian Pidgin among HNDII students of the Federal Polytechnic, Nasarawa. Pidgin emerges when people from different linguistic backgrounds need a means of verbal communication. Interviews and direct observation methods of investigation are used as means of gathering data for the study. Fishman’s theory of domain analysis is employed as a framework of analysis for the study. The study discovered the presence of Nigerian Pidgin on campuses and how it affects to a great extent the teaching and learning of Standard English in Nigerian higher institutions. This study has also been able to provide answers to such questions as who speaks Nigerian Pidgin, to whom, where and for what purpose. The implication of the use of Nigerian Pidgin in academics was also explored. On the whole, this research concludes with the notion that Nigerian Pidgin is used as a means of informal communication among students on Nigerian campuses; as such, it has negative implications on the teaching and learning of Standard English in our educational process.

The study examined the effects of socioeconomic determinants on educational outcomes in Nigeria. This study was done against the backdrop that the education sector of Nigeria has failed to produce quality educational outcomes needed for the growth of the nation’s economy despite enormous works on the topic by most scholars who failed to account for the combination and extent of the effect of infrastructure, ICT, per capita income, and corruption on education outcome in Nigeria. The study was carried out to investigate the effect of infrastructure, ICT, per capita income, and corruption on educational outcomes in Nigeria using time series data covering a period of 21 years (2000- 2020). The study employed the Autoregressive Distributed lag (ARDL) bounds testing approach to ascertain the relevant relationship while the ECM captured the speed of short-run adjustment to long-run equilibrium. The findings reveal that infrastructure and per capita income have a positive effect on education outcomes (with literacy rate as a proxy) in Nigeria with only infrastructure being statistically significant. The study also found that ICT and corruption negatively and insignificantly affect education outcomes in Nigeria. The study, therefore, recommends that emphasis should be shifted from education for all to learning for all, improvement in infrastructure, and incorporation of ICT in education to aid teaching and learning.

Objective: This systematic review is aimed to review the role of uterine artery Doppler in first trimester of pregnancy along with use of maternal characteristics as a predictor of early and late on set pre-eclampsia (PE). Selection Criteria: The search was limited by selecting; only original articles, prospective & retrospective study designs, role of uterine artery Doppler done at 11 to 14 weeks, done on singleton pregnancy and written in English language were included. Data Collection and Analysis: The data extracted for author name, year of publication, place of study, duration of study, study design, outcomes and study variables including maternal factors, uterine artery Doppler and serum markers. Then detailed analysis of uterine artery Doppler performance as predictor in the form of Area under curve, Sensitivity, Specificity, Positive predictive value, Negative Predictive Value and its relation to preeclampsia, Early PE and Late PE. Results: Following the search strategy of PRISMA, 148 full articles reviewed, and 21 articles were included from 2010 to 2021. Out of 21 articles, 19 articles had “prospective study design” whereas two had “retrospective. Out of 21 researches, 15 assessed early preeclampsia, 4 assessed late preeclampsia, 4 assessed both, however 7 articles studies only preeclampsia as an outcome. The extracted estimate show value of first trimester uterine Doppler as a predictor of early and late preeclampsia. Conclusions: The uterine artery Doppler with maternal characteristics is a valuable, noninvasive tool to be used at 11 to 14 weeks as predictor of preeclampsia in the low resource settings where serum markers cannot be available to general population.

Inflammatory bowel diseases (IBD) are Ulcerative colitis (UC) and Crohn‘s disease (CD). Conventional therapies are inadequate and are associated with several systemic side effects due to lack to localization of active moiety at the inflamed site. Colonic drug targeting is a novel potentially active area of research intended and focused on drug delivery for treating localized disease. Targeted drug delivery to the colon would ensure direct treatment at the disease site, lower dosing and fewer systemic side effects.

Chemotherapy induced peripheral neuropathy is a disabling pain condition resulting from cancer therapy. However, no scientific data available for many herbal drugs which are locally used and evaluating these drugs would be worth to have scientific approach of using them. In this study an indigenous plant called Clerodendrum viscosum leaves have been used to evaluate the effect of plant in vincristine induced peripheral neuropathy in rat model. Vincristine sulfate was administered to Male sprague dawley rats to induce neuropathy. Pain behavior was assessed by Hot plate, Cold plate, sciatic function index and formalin test were also estimated. Animals were sacrificed and the sciatic nerve excised for histopathological studies. The whole preclinical studies revealed that the aforementioned plant extract exhibited less neuronal damage. The study concluded that methanolic extract of Cleodendrum Viscosum leaves can used against chemotherapy induced peripheral neuropathy.

Background: Magnesium plays an import role in the physiology of parturition. Decrease of Magnesium in plasma may be responsible for a decrease of the same in myometrium and this might have a considerable influence on the preterm labour. A Hypomagnesaemia leads to neuromuscular irritability leading to uterine hyperactivity which leads to cervical dilation. Objective: To find out the association between serum magnesium and preterm level. Methods: This was a cross sectional study, conducted in 100 women in labour, of them 50 were diagnosed case of preterm labour and 50 women were in labour at term attended in Gynaecology and Obstetrics department of Dhaka Medical College, Dhaka, from January 2015 to December 2015.5ml fasting blood sample was collected and was analyzed for serum magnesium using a standard enzymatic method. The mean value of serum magnesium was compared between two groups by student unpaired t-test and serum magnesium level was correlated with BMI, Gravita and gestational age in preterm labour patients by Pearson’s correlation coefficient test. A p-value was considered to be statistically significant at 0.05 at a 95% confidence interval. Results: The mean age was found 28.2±4.5 years in group I and 26.7±4.1 years in group II. The mean age difference was not statistically significant (p>0.05) between two groups. A majority (80.0%) of the patients came from a middle-class family in group I and 29(58.0%) in group II. The mean BMI was found 23.0±3.8 kg/m2 in group I and 26.4±2.4 kg/m2 in group II. The socioeconomic status and BMI were statistically significant (p<0.05) between two groups. The mean serum magnesium was found 1.64±0.13 mg/dl in group I and 2.05±0.11 mg/dl in group II. The mean serum magnesium level was significantly (p<0.05) lesser in group I. Serum magnesium had an area under curve 0.974, which gave a cut-off value < 1.8 mg/dl, with 98.0% sensitivity and 88.0% specificity for prediction of preterm labour. Conclusion: Most of the patients were belonged to age 21-30 years in both groups are not associated. A negligible correlation was found with BMI, gravid, through serum magnesium in preterm labour. Low serum magnesium level was significantly higher in preterm labour.

In the making of the United States of America, rights related to life, liberty and pursuit of happiness hits blocs prejudices and society-based realities. Unlike whites, blacks witness cases of highly-ranked socio-economic hardships in settling families, providing the minimum possible for stable households and assuring well-mannered children from one generation to another. Failure to pass on a legacy of well-indicated morals, mores, attitudes and patterns is abundantly highlighted in Fences by August Wilson, with Troy Maxson the main character who definitely misses the point the same way his own father does with consequences on kids, wives and the whole living society. Psychoanalysis and Marxist literary theories help to denote and decode how generations of fathers as bread-winners pass on to extended families, principles for living which members of the same family accept or reject through manners in which they choose to live their own lives: unfulfilled responsibilities and generation gaps at stake.

This study examines the social and economic conditions of handloom weavers in Uttar Pradesh state of India. This study is primarily based on secondary data, and the data were evaluated using a simple percentage, an annual growth rate, and a compound annual growth rate. They were also shown in a pie chart and a bar chart. This study is based on the following key aspects such as location, age, gender, religion, social group, educational qualifications, type and size of family, employment status, type and ownership of dwelling units, ration card, source of loan and purpose of the loan, monthly household income from handloom-related activities, and ownership of looms. The study results indicated that most workers are men, and the number of women workers is not good. Most weavers in Uttar Pradesh are members of the Muslim religion or the OBC (Other Backward Class) social group. Most workers live in kutcha houses, especially in rural areas. In cities, more households live in pucca and semi-pucca houses than in rural areas. It was also found that most handloom workers (97.3%) have their own homes in rural areas. There aren't enough educated handloom weavers, and a study shows that most weavers have never been to school. It can be said that most of the weavers, or about 55 per cent, worked as independent weavers. About 40 per cent worked as master weavers. It was found that most, or 59.5 per cent, of weaver households, have an income of less than Rs. 5,000. It can be said that most (53.2% of the weaver households) have taken out a loan for handloom purposes. The study found that most (25.5%) handloom households got loans from the government, followed by commercial banks (21.9 per cent). It found that most weaver households (73.5% of them) work with looms and that 26.5 % of weaver household’s work without looms. The study found that more male weavers (66.1%) have bank accounts than female weavers (only 33.7%). The study found that more male weavers (66.1%) have bank accounts than female weavers (only 33.7%). It found that 62.4 per cent of male weavers and 37.5 per cent of female weavers have aadhar cards. Only two transgender people have Aadhar cards. Most households (60%) have a monthly household income of less than Rs. 5,000, but the monthly household income in cities is higher than in rural areas. It also shows that most of the sales of their main products come from the local market (46.1%) and master weaver (43.3 per cent).

The purpose of this research study was to investigate the effects of ethanolic stem bark extract of Persea americana on some reproductive parameters of female Wistar rats. In this study, female Wistar rats were randomly assigned into three (3) groups of 5 rats each. The control group (Group 1) was given distilled water. Group 2 received 200mg/kg of the extract and group 3 received 400mg/kg of the extract daily for a period of 21 days following acclimatization. The female rats were cohabited with males in the ratio 2:1 (M:F) for 10 days. Blood samples were collected and some tissues harvested at sacrifice. The statistical analysis was done using Statistical Package for Social Sciences (SPSS). One-way analysis of variance (ANOVA) test was used to compare groups followed by post-hoc testing to determine whether there were significant differences between the control and treatment groups. P-value less than 0.05 was considered significant and result presented as Mean±SEM. The result showed that the extract of Persea americana caused stimulatory effect on anterior pituitary synthesis of luteinizing hormone (LH) and follicle stimulating hormone (FSH) and may have also caused changes in the gonads leading to decreased gonadal hormone synthesis (estrogen and progesterone). The percentage fertility of the female Wistar rats was significantly reduced suggesting that the stem bark extract of Persea americana possess antifertility effects.

Objectives of the study: the metabolic syndrome (MS) consists of a group of metabolic alterations that have insulin resistance as their common denominator and identifies a pathophysiological condition at high risk of developing cardiovascular disease and type 2 diabetes. 20% and 30% of the adult population is affected by MS Design and method: in this article the authors try to make a scientific contribution regarding the problems of some patient populations often having to necessarily take drugs with an important metabolic impact while developing an iatrogenic-based MS (IMS) and propose to further investigate the aspects and the clinical pharmacological problems of the population of psychiatric patients at risk of MS. Results: Although the prevalence of MS has been observed to be often higher in the urban population of some developing countries, there are patient populations who develop MS due to the extensive use of certain drugs with obesogenic-metabolic adverse effects, in particular some generations of antidepressant and neuroleptic drugs (NL) used in mental disorders and antiretroviral drugs, such as integrase inhibitors used in HIV infection. Conclusions: Populations at risk of IMS should be at the center of the search for an individualized precision medicine with the careful choice of pharmacological therapies and appropriate lifestyle. Unfortunately, precision medicine in the psychiatric field seems to be stopping its growth due to the lack of identification of biomarkers and indicators of psychopathology.

Bacterial and viral therapies have gained enough success and attention for biological cancer treatments. There is a need to protect the living tissues of the body that are helpful for activating the immune responses. Many failures are associated with the conservational therapies that render them for the current era of medical sciences. Viral and bacterial genomes have been used for targeting the initial basis of metastasis and inhibiting the growth of cancerous cells. S. pyogenes OK-432 strain showed action against cancerous cells with intact bindings to the proliferative tissues. Phenazine 1-carboxylic acids have anticancer nature and pose a high level of cytotoxicity against the. Salmonella strain (KST0650) showed maximum potential against CT26 cancer cells. Oncolytic biologically and virologically group of the controlled viruses that have been used for tumor treatment. Some critical cancers under medications such as hormone therapy- induced helpful for prolonged life span. Pro-active drugs and combinations of probiotics also prevent the bacteria from synthesizing the protective layer of peptidoglycan.

Background: Hypertensive disorder is the most common medical problem encountered in pregnancy with a high perinatal and maternal mortality & morbidity. Worldwide about 76,000 pregnant women die each year from preeclampsia and related hypertensive disorders. Objective: To assess the relation between labetalol and methyldopa in treatment of pregnancy induced hypertension. Methods: This study was hospital based comparative prospective study was conducted at Dept. of Obstetrics & Gynaecology, Dhaka Medical College Hospital, Dhaka, Bangladesh from January to June 2021. The study consisted of 100 patients with pregnancy induced hypertension attending outpatient department and admitted in ANW, or who directly came to labour room. These patients were randomly selected on lottery basis after they fulfilled the inclusion criteria. Total patients were taken for the study and divided into 2 groups of 50 patients in each group. Results: A total 100 patients were included. The mean age in Group I was 24.4±4.55 years and in Group-II, 23.95±4.28 years. Maximum number of patients was between 19- 24 years in both the groups. In Group-I, 26 (52%) patients and in Group-II, 25 (50%) patients were in this age group. The maximum age in the Group I was 34 years and 35 years in the Group-II. The minimum age was 17 years in both the groups. The inter group difference was not statistically significant (p>0.05) thus the two groups were comparable by age. At baseline no significant difference was seen in SBP in both treatment groups. However after 8 days post testament SBP of women was significantly lower in Group-I patients as that of Group-II patients. i.e. Group-I: 123.41 vs. Group-II: 126.62, p- value=0.009. At baseline no significant difference was seen in DBP in both treatment groups. However at 8th day post treatment DBP of patients was significantly lower in Group-I patients. i.e. 77.18 vs. Group-II 79.64, p-value=0.005. For SBP more effective control was seen in women whose parity was 3-4 and for DBP notable difference was seen in women whose parity was 1-2. The control of systolic blood pressure was more effective in patients with normal body mass index and for Diastolic blood pressure (DBP) more effective control was seen in patients who were obese. On comparison methyldopa significantly causes more drowsiness, headache and nasal congestion and the incidence of Postural hypotension and dysponea in both groups were not significantly different. The patient who required additional drugs to control the uncontrolled hypertension. In Group I, 2 (4%) patients and in Group II, 3 (6%) patients did not respond with starting drug. The inter group difference was not statistically significant (p>0.05). Conclusion: Labetalol had less maternal adverse effect compared to methyldopa but fetal outcome was not observed in this study. Labetalol and methyldopa are equally efficacious in controlling blood pressure in new onset hypertension in pregnancy. This study is just a step in this long way. Therefore, labetalol can be considered positively in the treatment of pregnancy induced hypertension.