Background: Patient satisfaction is a crucial aspect of healthcare, as it not only affects the overall quality of care but also influences patient outcomes and hospital reputation. Nurse-Initiated Rounds are when nurses take the lead in patient care rounds, which can help to enhance patient satisfaction by delivering more customized care and attention. Collaborative pharmacist involvement, on the other hand, can help enhance medication management and eliminate medication errors, resulting in higher patient satisfaction. Therefore, the purpose of the study was to evaluate the impact of Nurse-Initiated Rounds with Collaborative Pharmacist Involvement on patient satisfaction. Methods: A clinical trial using a non-equivalent control group design was used in the study by involving 68 participants from the hospital medical and surgical wards. The participants were assessed using the Newcastle Satisfaction with Nursing Scale and a tool to measure patient satisfaction with pharmaceutical care. The study group received the Nurse- initiated rounds of collaborative pharmacist involvement. The data were analyzed by using descriptive and inferential statistics. Results: The study reported that the experimental group, which received nurse-initiated rounds with collaborative pharmacist involvement, demonstrated significantly higher levels of patient satisfaction compared to the control group on various aspects of nursing care and pharmaceutical care. The experimental group's mean score on the first day was 6.06 (SD=0.531), whereas the control group's was 4.75 (SD=1.578). Conversely, the experimental group scored 8.21 (SD=0.632) on the fifth day of hospitalization, compared to 5.76 (SD=2.227) for the control group. Conclusion: The study findings concluded that nurse-initiated rounds with collaborative pharmacist involvement resulted in in higher satisfaction, improved drug management, and better patient care and attention. The findings also emphasized on importance of inter-professional collaboration and patient-centered care in improving satisfaction levels and overall healthcare outcomes.