Rungia repens is a common Acanthaceae member growing mostly in agricultural wastelands. This plant is noted to have febrifuge, antitussive, and vermifuge properties. The qualitative phytochemical study of the leaves and stem of R. repens showed that the plant is rich in phytochemical composition. The chemical analysis showed the presence of alkaloids, phenolics, cardiac glycosides, and steroids in the methanolic extract of this plant. The DPPH and FRAP assay showed that the plant parts have significant antioxidant potential. The disc diffusion of the methanolic extract of this plant reveals its antimicrobial activity. Thus, it is stated that the plant has significant antioxidant and antimicrobial potential.