Digestive manifestations during systemic lupus erythematosus (SLE) are rarely reported in the literature, in particular, hepato-pancreatic manifestations. We report the case of a patient in whom SLE was revealed by acute hepato-pancreatitis with mixed acute hepatitis, acute pancreatitis fulfilling 2 diagnostic criteria (high lipasemia and Balthazar stage C pancreatitis on the abdominal CT scan). The diagnosis was retained on the ACR criteria. The evolution under corticosteroid therapy and resting of the digestive tract was favorable.