Patients in the intensive care unit are treated with many interventions to keep them on rest. A number of sedatives are used in ICU for this purpose. The main aim of sedation is to control pain. Benzodiazepines are commonly used as sedative agents and adjuvants. Many adverse effects such as CNS depression and respiratory depression have been associated with the use of these drugs. Propofol has satisfactory sedative effects. It can also be combined with other medicines to achieve the required results. Slow heart rate (Bradycardia), low blood pressure (Hypotension), and hyperlipidemia are common effects after the infusion of Propofol. Dexmedetomidine (DEX) is a suitable drug for sedation in cardiac patients. Less respiratory depression and analgesia are advantages of Dexmedetomidine over benzodiazepines. It can be concluded that the dose of sedatives must keep to a minimum effective level for having safe results for the patient and to make the patient mobilized at the earliest when possible.