Acute inflammatory demyelinating polyradiculoneuropathy (AIDP), also known as Guillain-Barre syndrome (GBS), is an autoimmune disease that is typically present as a progressive ascending weakness, with subtle or no sensory findings, and reduced or absent deep tendon reflexes. In this case report I am presenting a patient who presented with an atypical clinical feature of AIDP in the form of a descending rather than ascending weakness, highlighting the importance of considering AIDP as a potential diagnosis in such atypical presentations.