Background: The liver has a vital role in the hemostatic system. It is the site of synthesis of proteins responsible for clotting factors and their inhibitors. Liver infections/ diseases pose the effective functioning of the liver enzymes and clotting profiles. Objective of Study: This retrospective study aims to determine the plasma level of APTT, PT, in patients with chronic disease state in the University of Abuja Teaching Hospital, Gwagwalada, Nigeria. Materials and Methods: A total of 144 participants were enrolled for this study; both PT and APTT were analyzed using Quick and kaolin methods, respectively. Results: 144 candidates who met the inclusion criteria were recruited for this study. table 1.0 and 2.0 showed relationship between PT and APTT in liver infections/ diseases respectively, among the subjects, 81 subjects had Asymptomatic HBV Infection with mean ± SD of 15.3704± 3.0391, 18 Asymptomatic HCV infection, 2 HBV and HCV coinfection, 34 Chronic HBV, 6 Chronic HCV, 1 HCV/HIV coinfection, 1 Chronic HCV /HIV coinfection, 1 HBV/HIV coinfection, and Liver cirrhosis. They was non-statistically significant decrease in the level of PT among patients with both asymptomatic and chronic HBV, HCV, HBV and HCV co-infection, HBV co-infection with HIV, HCV co-infection with HIV and patients with liver cirrhosis with P-value of 0.229. Conclusion: Findings from this study demonstrated that coagulation profile has an association with liver disease.