Four simple, sensitive, precise and accurate spectrophotometric methods A, B, C and D have been developed for the quantitative estimation of Naftopidil. UV method (A) has been developed by using alcohol as the solvent. The wavelength of maximum absorbance selected was 269nm. The method was linear between the range of 2-10g/ml with correlation coefficient of 0.9999. %RSD of precision was calculated and found to be 0.965. Colorimetric Methods B, C and D have been developed by oxidation followed by complex formation reaction using 1,10- phenanthroline, 2,2’- bipyridyl and Potassium ferricyanide respectively, using ferric chloride as oxidizing agent. Regression analysis for the methods was carried out and the correlation coefficient was found to be between the range of 0.99969-0.9999 depicting very good linear relationship between the concentration of the drug and corresponding absorbance values. % RSD of precision for the three colorimetric methods was calculated and found between the range of 0.4126-1.1354 showing that the methods are precise. Accuracy studies were carried out at three different levels and the results fall between the range of 99.89 to 99.96.