Pituitary abscess is a rare, but potentially life-threatening condition unless promptly diagnosed and treated, and it accounts for less than 1% of all pituitary diseases, few cases have then been published in the literature, the majority of this cases are diagnosed either post mortem or post operatively. Pituitary abscesses may occur in a normal pituitary gland in 70% of cases (primary types), or secondary to a preexisting lesion. We report a successfully managed case of a 66-year-old woman. We discuss the pathogenicity, the morphologic and radiologic criteria suggestive of this unusual infection of pituitary region and also treatment options