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Saudi Journal of Medical and Pharmaceutical Sciences (SJMPS)
Volume-5 | Issue-07 | 659-662
Original Research Article
Celiac Disease Associated with Plummer-Vinson Syndrome
S. Lajouad, I. Benelbarhdadi, C. Berhili, N. Lagdali, M. Borahma, F.Z Ajana
Published : July 30, 2019
DOI : 10.36348/sjmps.2019.v05i07.015
Abstract
Introduction: Plummer-Vinson syndrome (PVS), also known as sideropenic dysphagia, is a very rare entity that combines a classic triad: iron deficiency anemia, dysphagia and upper esophageal diaphragm. Its association with celiac disease has been rarely reported. The goal of this work is to determine the clinical characteristics of patients with PVS, in celiac disease, thus the evolutionary profile. Materials and Methods: This is a descriptive retrospective study covering a period of 26 years, from January 1993 to January 2019, collecting all patients followed in the service of Medecine C at the University Hospital Ibn Sina of Rabat-Morocco for PVS who have systematically benefited from jealousy biopsies in search of celiac disease. Results: Out of a total of 149 patients followed in the PVS unit, the prevalence of celiac disease was 6.1% (10 cases). 8 cases diagnosed as part of the etiological assessment of PVS, the diagnosis of celiac disease was concomitant with PVS in 2 cases. These were 8 women and 2 men with a sex ratio of 0.25. The average age was 28 years [19- 56 years]. All patients had organic dysphagia, five cases (62.5%) had clinical anemic syndrome associated with malabsorption diarrhea. Upper GI fibroscopy showed a ring at the killian's mouth in all cases. After oesophageal dilation by candles of different diameters, fibroscopy showed a rarefaction of duodenal folds in 9 cases (90%) and a duodenum of normal appearance in one case (10%). The anatomopathological study of duodenal biopsies showed intraepithelial lymphocytosis (IEL) > 30% in all cases, moderate atrophy of the villus in 6 cases and severe atrophy in 4 patients. All our patients have received martial treatment in combination with a gluten-free diet (GFD). The progression was favourable in 8 patients after a single dilation session and a well-followed GFD; 2 patients with poor GFD compliance also had a recurrence of dysphagia. Conclusion: PVS on celiac disease remains rare, found only in 3.5% in our series; good compliance with the GFD has improved signs of malabsorption and the disappearance of dysphagia in 80%.
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