Although remarkable advances have been made in the detection and management of mood disorders over the last few decades, the increasing worldwide prevalence of depression continues to challenge researchers and clinicians alike. In spite of the availability of antidepressant drugs depression continue to be a major medical problem. Although there are many effective antidepressants available today, the current therapy is often inadequate with unsatisfactory results in about one third of all subjects treated. Various plants are being used in complementary and alternative medicines for management of mood disorders. The methanol stem-bark extract of Ficus vallis was investigated for antidepressant activity using the Forced Swim Test and Tail Suspension Test models. The locomotor activity was also evaluated using the Open Field Test so as to rule out possible psyco-stimulant activity. It was observed from our study that Ficus vallis methanol extract showed significant (p < 0.05) reduction in immobility at 200 and 400 mg/kg doses in the Tail Suspension Test. While in the Forced Swim Test there was a significant (p < 0.02) with the 400 mg/kg dose when compared with normal saline. The methanol stem-bark extract of Ficus vallis possesses antidepressant properties in mice with significant decrease in duration of immobility.