Objective: To study the clinic bacteriological profile and outcome of Empyema Thoracis in children between 1 month to 12 years of age admitted at Calcutta National Medical College and Hospital (CNMCH), Kolkata. Methods: Study subjects were enrolled from children admitted at Paediatrics Department of CNMCH, Kolkata with fever, cough, respiratory distress and diagnosed as Empyema Thoracis by basic investigations like Chest X Ray (CXR), Pleural fluid analysis,Ultrasonography of Chest (USG chest), blood culture and sensitivity. Result: Rapid diagnosis by basic investigations and early initiation of IV antibiotics with intercostal chest tube drainage was an effective method of therapy. The common organisms isolated were Staphylococcus aureus and Streptococcus pneumoniae. Only 4% cases of the sample size required surgical intervention. Malnutrition was an important co morbid condition. Conclusion: IV antibiotics and intercostal chest tube drainage is an effective means of therapy of Empyema Thoracis in children at resource poor settings.