Background: Many patients diagnosed with autoimmune connective tissue disease cannot be categorised easily into one of the established clinical entities such as systemic lupus erythematosus, dermatomyositis, or systemic sclerosis. The term overlap syndrome is used to identify such patient and is useful in terms of clarifying prognosis and facilitating disease management. Methods: This was a retrospective study of the patients diagnosed with connective tissue diseases. The study was done among patients attending the outpatient clinic of a teaching hospital in the South Western Nigeria. The study spanned from July 2013 to June 2016. Data on clinical characteristics, diagnosis, age at onset of disease, and gender were extracted from their files. Results: Five hundred and two patients attended the rheumatology outpatient clinic over the study period. There were 41(8.2%) cases of connective tissue disease. Systemic lupus erythematosus constituted 29.3%, undifferentiated connective tissue disease 19.5%, and scleroderma 14.6%. Others were secondary Sjogren's syndrome 14.6% and overlap syndrome 7.3%. There were 3 overlap syndromes and all were females. A case of rheumatoid arthritis/systemic lupus erythematosus (RA/SLE), SLE/polymyositis, and Scleroderma/Polymyositis. Patients were aged 18 to 64 years, and the mean age was 42±5 years. Female constituted 85.4% of the total population with a female to male ratio of 5.8:1. Conclusion: There is the need to detect an overlap syndrome early. An early classification will guide the management plan of such patients. The traditional high dose steroid for the treatment of SLE and inflammatory muscle disease may be hazardous in overlap syndromes.