The aim of this study is to determine the effectiveness of corrugated rubber and tube drains in the management of Ludwig’s angina patients. This retrospective comparative study was designed for patients with Ludwig’s angina that presented to the Department of Oral and Maxillofacial Surgery, University of Benin teaching hospital, Nigeria between June 2008 and July 2018. Data collected from the case notes of the patients were age, gender, type of surgical drain, airway compromise, length of hospital stay, and retreatment. Descriptive and inferential statistics were performed with SPSS Version 17(SPSS Inc, Chicago, USA). All tests were 2-sided and P-Value less than 0.05 was considered statistically significant. Of the 55 patients studied, 32 (57.3%) had plastic tube drains while 23 (42.7%) had corrugated rubber drains. Their ages ranged from 19-72 years with a mean ± SD of 42.1 ± 13.7 years. There was significant higher incidence of airway compromise in patients that had corrugated rubber drains compared to those that had plastic tube drains inserted(P=0.03). However, the type of drain inserted was not an independent predictor of the presence of airway compromise in our patients. There were no significant differences between the two groups as regard retreatment and length of hospital stay. The insertion of open tube drain is as effective as the conventional corrugated rubber drain as it could decrease complications and improve the prognosis for patients with Ludwig’s angina.