Objective: The clinical characteristics and experience of rural Indian children of West Bengal with paraquat poisoning – a retro prospective analysis. Methods: The study: From June 2014 through April 2019, fourteen children with paraquat poisoning who presented to the hospital were enrolled .The collected clinical indices of these cases were and analyzed. Results: oral ingestion of paraquat were found in most of the children and the commonest route of poisoning. Different degrees of damage were found in multiple systems in their bodies. Initial therapy consists of removing the paraquat from the body (decontamination) and preventing further absorption for oral exposures by using activated charcoal followed by pulse therapy using methylprednisolone (20 mg/kg/d×3d) and Gamma globulin (total 2 g/kg divided into 3 d to 5 d)for all children in the early stage. Prednisone was then given orally for 4wk to 8 wk. The total mortality rate of the patients was 64.8% (09 of 14 patients died). Statistical differences (P<0.05) were found between the surviving and dead patients, with regard to age, plasma paraquat levels, the highest levels of alanine aminotransferase, aspartate aminotransferase, γ-glutamyl transferase, total bilirubin, direct bilirubin, indirect bilirubin, blood urea nitrogen,creatinine and pH value, the lowest levels of PaO2, PaCO2 and SaO2. Plasma paraquat level was positively related to pH value, but was negatively related to PaO2, PaCO2 and SaO2 levels. Hepatic and renal complications are encountered in admitted patients but the patients survived.However the fibrosis of the lung is one of the dreaded complications in the long run. Conclusions: There is no cure for Paraquat poisoning. In this study, pulmonary fibrosis was the primary cause of death.Treatment by administering pulse doses of methyl prednisolone and Gamma globulin seems to be effective in the early stage. However, the treatment may not reverse the development of pulmonary fibrosis. The long-term prognosis of paraquat poisoning was not optimistic.For predicting the prognosis, plasma paraquat level is significant.