Background: Periodontal diseases could be regarded as an independent risk factor for the onset of cardiovascular diseases. Evidence documents that periodontal diseases have an independent statistically significant association with cardiovascular diseases, although weak to moderate, after adjusting for potential confounding factors, such as advancing age, gender, race, smoking, hypertension, diabetes, indicators of socioeconomic status, stress, obesity, lipid rich diet and others. Aim: The aim of the study is to evaluate a correlation between periodontitis and ECG abnormalities. Materials and Methods: This is a cross-sectional study constituting 15 systemically healthy subjects with moderate to severe periodontitis and 15 systemically healthy subjects without periodontitis. Subjects were selected with proper inclusion and exclusion criteria. For each patient clinical parameters including PI, MGI, PD, CAL, BP and Electrocardiograph (ECG) are recorded. ECG changes like LVH, ST depression etc. are evaluated and the relation with periodontal condition is assessed. Results: No significant ECG abnormalities were detected in moderate-severe chronic generalised periodontitis patients. Conclusion: The present study did not find a relationship between periodontitis and ECG abnormalities. Further longitudinal studies with a larger sample size are required to associate the relationship.