The aim to conduct this case study, because Pituitary Macroadenoma leading to aspergillus is a rare condition. In which the main pathogen of fungal sellar is aspergillus species. The pituitary infectious fungi consisted on different groups and dimorphic fungi. The leading pathogen of fungal sellar abscess is the type of aspergillus. The possible route of infection through sphenoid sinus with a thin sellar roof. Pituitary tumour differentiate through its size. Pituitary tumors undesirably known to grow in the, sphenoid bone, cavernous sinus, mid-nasal ductus, and left cerebral hemisphere. In our case presentation patient presented with pituitary macroadenoma, which diagnosed through magnetic resonance imaging. Presented with nasal mass, and acromegaly features, headache. Right eye vision loss. Through endoscopy biopsy report shows the nasal fungal infection. Surgical treatment, trans-sphenoidal procedure will be planned as recommended in literature reviews.