This cross-sectional descriptive study using convenience sampling technique was conducted in rural Thane district in Maharashtra State on male adolescents (n=200) to determine their health-related behaviour and health profile. A pre-tested formatted proforma was used to record socio-demographic and health-related data. Their mean age was 17.81  1.20 years (95% CI: 17.65–17.98 years). 153 (76.5%) belonged to lower middle class and the rest to lower class as per B.G. Prasad Classification. 64.5% were students while 35.5% had dropped out of studies. The participants had relatively good personal hygiene. Consumers of alcohol and tobacco comprised 10.0% and 15.5%, respectively. Their current health-related problems comprised dental conditions (15%), skin diseases (12.5%), eye conditions (6.5%), ear problems (2.5%), vitamin A deficiency (2%) and vitamin B deficiency (1.5%). Self-reported history of past illness included tuberculosis, typhoid, upper respiratory tract infection, dengue, malaria and jaundice. The illnesses among family members included tuberculosis, diabetes and hypertension. Periodic health assessment of adolescents can help initiate early interventions. Community-level educational intervention can help in coping with nutritional deficiencies.