Introduction: The human immunodeficiency virus (HIV) has been decisively established as the cause of AIDS.AIDS scientist presents these results as strong evidence that HIV is the cause of AIDS. Such arguments are very persuasive to public and most scientists, even though there is debate among different scientists. Objectives: To review HIV the cause of AIDS or not. Methods: systematic literature review in methodology was used. The review was conducted using reliable healthcare internet database namely; Google scholar, hinari and PubMed central. Ten scientific articles were scrutinized to obtain results for the review. Result: The result of this review showed that a total of six articles were reviewed which talks about the belief and evidence are that HIV is causes of AIDS. Conclusion: Even if there is a debate among scientists about whether HIV causes AIDS was related to refusing HIV treatments and poorer health outcomes. And following or accepting the positive one that is HIV causes AIDS do not have side effect without improving of quality of life.