Plants have formed the basis of sophisticated traditional medicinal systems that have been in existence for thousands of years and continue to provide mankind with new remedies. The study of total ethanol extract of Shorea robusta oleoresin and Wrightia tinctoria bark investigated the antiallergic activity study by sheep (Capra hircus) serum and compound 48/80 induced mast cell degranulation method using ketotifen fumarate and antipruritic activity study by compound 48/80 method using chlorpheniramine maleate as standard. The results showed both plants are excellent candidates.