Patients undergoing surgery are most feared of postoperative pain. All the techniques for multimodal analgesia has some or the other side effects. Transversus abdominis plane (TAP) block is newer, effective and comparatively simpler to perform and provides better and denser pain relief than pharmacological agents. It could be used in abdominal and inguinal surgeries. This randomized control study was conducted on 60 male patients of ASA grade 1 and 2 undergoing open prostectomy after taking ethics committee approval. In group L (n = 30), 0.25% Levobupivacaine hydrochloride (20ml) and in group S (n=30), 20 ml of normal saline was given through TAP block after completion of surgery. Time of first rescue analgesia and total dose of analgesic consumption for 24 hour postoperatively along with pain visual analogue scale (VAS) were measured and compared along with other vitals like heart rate, SBP, DBP and MAP. Postoperatively, TAP block using levobupivacaine just after completion of surgery results in better analgesia in post-operative period in patients undergoing open prostectomy. Time of rescue analgesia in group L was 209.3±27.25min and in group S was 70.6±9.8 min. Also total analgesic dose consumption and VAS score in postoperative period was significantly low in levobupivacaine group when compared with the saline or control group (p<0.05). TAP block using levobupivacaine 0.25% in open prostectomy patients provide better analgesia in postoperative period and reduces amount of total analgesic consumption and thus the side effects associated with the later.