Vernal keratoconjunctivitis (VKC) is an unusually severe allergic eye disease, occurring mainly in children. Giant papillae are frequently observed on the upper tarsal conjunctiva and expose, sometimes, to severe corneal complications, involving the visual prognosis. Other allergic states, conjunctival staphylococcus aerus and worm intestinal infection, were frequently associated with VKC. We report the case of a 9-year-old girl followed for five years for severe vernal keratoconjunctivitis resistant to treatment with topical corticosteroid. In front of, the high ASLO title, the isolation of pyogenic streptococcus in the throat swab culture, and the presence of a chronic pansinusitis, the diagnosis of a post-streptococcal syndrome was retained. The patient is treated with protected amoxicillin for 12 days. The evolution was spectacular with almost total disappearance of the giant papillae without any recurrence, after 6 months of follow-up. In our knowledge, this case is the first case of vernal keratoconjunctivitis with giant papillae reported as being a post-streptococcal immune complication. Ophthalmologists, confronted to vernal keratoconjunctivitis, should consider post-streptococcal syndrome as a possible cause. The search for an increasing title of ASLO and streptococcal infectious evidence can establishes the association.