Persistent Genital Arousal Disorder (PAGD) is an uncommon female sexual dysfunction that was first described in 2001. It is a condition that has been under-researched and not fully understood for so many years. Its prevalence is estimated to be between .5% to 6.7%, but it is believed to be under-reported because of the stigmatization of the disorder, as it is characterized by prolonged periods of persistent subjective feelings of genital arousal that are recurrent, intrusive and distressing, which usually subside by masturbation resulting in orgasm. These symptoms are not associated with sexual thoughts or urges, which prompted sex therapists and researchers to change its name from persistent sexual arousal disorder to PGAD. Now that we have a better understanding of its risk factors and pathophysiology, this review article will guide gynecologists, general practitioners and pelvic floor physiotherapists to diagnose, investigate the cause and treat patients with PGAD.