Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) which acts as an analgesic and antipyretic drug. This research work was aimed at demonstrating the effects of oral administration of indomethacin on some biochemical parameters in plasma of male wistar albino rats. Each of the 15 male wistar albino rats in experimental group one was given 2mg/kg of indomethacin capsule daily for two weeks while the other 15 male wistar albino rats in the experimental group two were given 2mg/kg each of indomethacin daily for four weeks. However, the 15 male wistar albino rats in the control group were not administered with indomethacin. Five ml blood specimen was collected from each of the groups into lithium heparinized anticoagulated bottles respectively. The specimen was spun and the plasma obtained was used for the quantitative measurement of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, urea and creatinine. The results revealed significant elevations (P<0.05) in the mean values of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, urea and creatinine in the male wistar albino rats administered orally with indomethacin for four weeks as compared to that of the control group. It was further revealed from the result that the mean values of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, urea and creatinine were not significantly elevated (P>0.05) in the rats administered with indomethacin for two weeks as compared to that of the control group. The elevated levels in the mean values of the rats orally administered with indomethacin for four weeks may suggest damage on their liver and kidney. It is therefore recommended that further histopathological examinations of these organs be carried out in order to ascertain the extent of damage.