The main objective of the work was to evaluate the acute and subacute toxicities of the combinated of aqueous extracts of the bark trunk of Musanga cecropioides and the fruit of Combretum micranthum. The respective extraction yields of 12% and 3.6% were obtained for Combretum micranthum and Musanga cecropioides. Tests of alkaloids, sterols, terpenes, phenols, flavonoids, saponins, coumarins, reducing sugars, tannins were positive with at least one solvent while those of anthraquinones and anthocyanins were negative, with all solvents whatever the species considered. At the end of the fourteen days of study of the acute toxicity, no abnormality of the studied parameters was observed, except for the aggressiveness of the rats, during the first five days. Most parameters varied in different groups during the subacute toxicity study. The values of blood biochemical and hematological parameters of the rats fluctuated sometimes. The study pharmacological activities in vitro and in vivo would allow the development of medicinal products based on these medicinal plants.